FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561071919> ?p ?o ?g. }

• W1561071919 abstract "Malignant pleural mesothelioma (MPM) is an asbestos-related thoracic malignancy that is characterized by late metastases, and resistance to therapeutic modalities. The toxic side-effects of MPM therapies often limit their clinical effectiveness, thus necessitating development of new agents to effectively treat and manage this disease in clinic. CARP-1 functional mimetics (CFMs) are a novel class of compounds that inhibit growth of diverse cancer cell types. Here we investigated MPM cell growth suppression by the CFMs and the molecular mechanisms involved. CFM-1, -4, and -5 inhibited MPM cell growth, in vitro, in part by stimulating apoptosis. Apoptosis by CFM-4 involved activation of pro-apoptotic stress-activated kinases (SAPKs) p38 and JNK, elevated CARP-1 expression, cleavage of PARP1, and loss of the oncogene c-myc as well as mitotic cyclin B1. Treatments of MPM cells with CFM-4 resulted in depletion of NF-κB signaling inhibitor ABIN1 and Inhibitory κB (IκB)α and β, while increasing expression of pro-apoptotic death receptor (DR) 4 protein. CFM-4 enhanced expression of serine-phosphorylated podoplanin and cleavage of vimetin. CFMs also attenuated biological properties of the MPM cells by blocking their abilities to migrate, form colonies in suspension, and invade through the matrix-coated membranes. Both podoplanin and vimentin regulate processes of cell motility and invasion, and their expression often correlates with metastatic disease, and poor prognosis. The fact that phosphorylation of serines in the cytoplasmic domain of podoplanin interferes with processes of cellular motility, CFM-4-dependent elevated phosphorylated podoplanin and cleavage of vimentin underscore a metastasis inhibitory property of these compounds, and suggest that CFMs and/or their future analogs have potential as anti-MPM agents.Citation Format: Shazia Jamal, Vino T. Cheriyan, Magesh Muthu, Sara Munie, Edi Levi, Abdelkader E. Ashour, Harvey I. Pass, Anil Wali, Mandip Singh, Arun K. Rishi. CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2711. doi:10.1158/1538-7445.AM2014-2711" @default.
• W1561071919 created "2016-06-24" @default.
• W1561071919 creator A5001225013 @default.
• W1561071919 creator A5005670285 @default.
• W1561071919 creator A5018818727 @default.
• W1561071919 creator A5026031583 @default.
• W1561071919 creator A5057434088 @default.
• W1561071919 creator A5061206336 @default.
• W1561071919 creator A5077195233 @default.
• W1561071919 creator A5089003708 @default.
• W1561071919 creator A5091299701 @default.
• W1561071919 creator A5091506580 @default.
• W1561071919 date "2014-09-30" @default.
• W1561071919 modified "2023-10-15" @default.
• W1561071919 title "Abstract 2711: CARP-1 functional mimetics are a novel class of small molecule inhibitors of malignant pleural mesothelioma cells" @default.
• W1561071919 doi "https://doi.org/10.1158/1538-7445.am2014-2711" @default.
• W1561071919 hasPublicationYear "2014" @default.
• W1561071919 type Work @default.
• W1561071919 sameAs 1561071919 @default.
• W1561071919 citedByCount "0" @default.
• W1561071919 crossrefType "proceedings-article" @default.
• W1561071919 hasAuthorship W1561071919A5001225013 @default.
• W1561071919 hasAuthorship W1561071919A5005670285 @default.
• W1561071919 hasAuthorship W1561071919A5018818727 @default.
• W1561071919 hasAuthorship W1561071919A5026031583 @default.
• W1561071919 hasAuthorship W1561071919A5057434088 @default.
• W1561071919 hasAuthorship W1561071919A5061206336 @default.
• W1561071919 hasAuthorship W1561071919A5077195233 @default.
• W1561071919 hasAuthorship W1561071919A5089003708 @default.
• W1561071919 hasAuthorship W1561071919A5091299701 @default.
• W1561071919 hasAuthorship W1561071919A5091506580 @default.
• W1561071919 hasConcept C185592680 @default.
• W1561071919 hasConcept C190283241 @default.
• W1561071919 hasConcept C2775975398 @default.
• W1561071919 hasConcept C31573885 @default.
• W1561071919 hasConcept C33195913 @default.
• W1561071919 hasConcept C502942594 @default.
• W1561071919 hasConcept C55493867 @default.
• W1561071919 hasConcept C86803240 @default.
• W1561071919 hasConcept C95444343 @default.
• W1561071919 hasConcept C98424977 @default.
• W1561071919 hasConceptScore W1561071919C185592680 @default.
• W1561071919 hasConceptScore W1561071919C190283241 @default.
• W1561071919 hasConceptScore W1561071919C2775975398 @default.
• W1561071919 hasConceptScore W1561071919C31573885 @default.
• W1561071919 hasConceptScore W1561071919C33195913 @default.
• W1561071919 hasConceptScore W1561071919C502942594 @default.
• W1561071919 hasConceptScore W1561071919C55493867 @default.
• W1561071919 hasConceptScore W1561071919C86803240 @default.
• W1561071919 hasConceptScore W1561071919C95444343 @default.
• W1561071919 hasConceptScore W1561071919C98424977 @default.
• W1561071919 hasLocation W15610719191 @default.
• W1561071919 hasOpenAccess W1561071919 @default.
• W1561071919 hasPrimaryLocation W15610719191 @default.
• W1561071919 hasRelatedWork W1967264415 @default.
• W1561071919 hasRelatedWork W19916217 @default.
• W1561071919 hasRelatedWork W2000225649 @default.
• W1561071919 hasRelatedWork W2036855371 @default.
• W1561071919 hasRelatedWork W2074148448 @default.
• W1561071919 hasRelatedWork W2083350896 @default.
• W1561071919 hasRelatedWork W2139471821 @default.
• W1561071919 hasRelatedWork W2145626047 @default.
• W1561071919 hasRelatedWork W2594560619 @default.
• W1561071919 hasRelatedWork W2605624004 @default.
• W1561071919 isParatext "false" @default.
• W1561071919 isRetracted "false" @default.
• W1561071919 magId "1561071919" @default.
• W1561071919 workType "article" @default.