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- W156123332 endingPage "227" @default.
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- W156123332 abstract "It is well known that aberrant microenvironmental conditions in solid tumors negatively impact their response to conventional anticancer therapies. Indeed the presence of hypoxia in the primary tumor has been identified as a prognostic indicator of treatment outcome in a number of clinical settings. Hypoxic conditions can arise at the limits of oxygen diffusion from blood vessels (diffusion or chronic hypoxia) or as a consequence of vascular collapse (perfusion or acute hypoxia). Both types of hypoxia upregulate key signaling pathways associated with metastasis and related tumor cell behavior and function; and although the impact of acute and chronic oxygen deprivation on these pathways may differ markedly, the effect of such exposures is to significantly enhance the metastatic phenotype. In lieu of the critical role of metastasis in treatment failures, there has been significant interest in developing molecular targeting strategies that impair signaling pathways associated with tumor cell dissemination. Many of these targeted tumor cell associated functions are enhanced by hypoxia, including invasion and angiogenesis. Agents targeting angiogenesis are of interest because they could interfere with the progression of established microtumor deposits to macroscopic size by interfering with blood vessel development but they also raise the caveat that the use of such agents might induce hypoxia in the primary tumor which could conceivably enhance the dissemination of tumor cells. This chapter discusses the impact of oxygen deficiencies on the maintenance of stem-like characteristics of tumor initiating cells, the potential interplay between genomic markers and hypoxia/HIFs, and the effect of hypoxia on signaling pathway critical to the metastatic process, including VEGF, c-Src, and the HGF/c-Met axis. It further explores how the interference with signaling molecules may have significant therapeutic potential in the development of novel therapeutic intervention approaches for the treatment of cancer metastasis." @default.
- W156123332 created "2016-06-24" @default.
- W156123332 creator A5026645047 @default.
- W156123332 creator A5043984767 @default.
- W156123332 creator A5083947131 @default.
- W156123332 date "2013-11-09" @default.
- W156123332 modified "2023-09-25" @default.
- W156123332 title "Hypoxia, Metastasis, and Antiangiogenic Therapies" @default.
- W156123332 cites W127859200 @default.
- W156123332 cites W133747171 @default.
- W156123332 cites W1481881961 @default.
- W156123332 cites W1511067168 @default.
- W156123332 cites W1536452773 @default.
- W156123332 cites W1573363574 @default.
- W156123332 cites W1585788873 @default.
- W156123332 cites W1589166971 @default.
- W156123332 cites W1603230122 @default.
- W156123332 cites W164299723 @default.
- W156123332 cites W1821406191 @default.
- W156123332 cites W1963651489 @default.
- W156123332 cites W1965478720 @default.
- W156123332 cites W1965596636 @default.
- W156123332 cites W1966049129 @default.
- W156123332 cites W1966063111 @default.
- W156123332 cites W1967600348 @default.
- W156123332 cites W1968662491 @default.
- W156123332 cites W1969269674 @default.
- W156123332 cites W1970213932 @default.
- W156123332 cites W1970903764 @default.
- W156123332 cites W1971001418 @default.
- W156123332 cites W1971182358 @default.
- W156123332 cites W1973541913 @default.
- W156123332 cites W1975448482 @default.
- W156123332 cites W1976999762 @default.
- W156123332 cites W1978139448 @default.
- W156123332 cites W1978979348 @default.
- W156123332 cites W1979157744 @default.
- W156123332 cites W1979452780 @default.
- W156123332 cites W1979858258 @default.
- W156123332 cites W1981954986 @default.
- W156123332 cites W1982317652 @default.
- W156123332 cites W1983225862 @default.
- W156123332 cites W1985562847 @default.
- W156123332 cites W1986159749 @default.
- W156123332 cites W1987359152 @default.
- W156123332 cites W1987606222 @default.
- W156123332 cites W1990418094 @default.
- W156123332 cites W1990577364 @default.
- W156123332 cites W1991371485 @default.
- W156123332 cites W1991541715 @default.
- W156123332 cites W1993323132 @default.
- W156123332 cites W1996830477 @default.
- W156123332 cites W1997203401 @default.
- W156123332 cites W1997299298 @default.
- W156123332 cites W2007269128 @default.
- W156123332 cites W2007287727 @default.
- W156123332 cites W2007897263 @default.
- W156123332 cites W2010348837 @default.
- W156123332 cites W2011100473 @default.
- W156123332 cites W2011810742 @default.
- W156123332 cites W2012078324 @default.
- W156123332 cites W2012276721 @default.
- W156123332 cites W2013033367 @default.
- W156123332 cites W2014144825 @default.
- W156123332 cites W2015831734 @default.
- W156123332 cites W2016579969 @default.
- W156123332 cites W2016861891 @default.
- W156123332 cites W2017362306 @default.
- W156123332 cites W2021006272 @default.
- W156123332 cites W2022233074 @default.
- W156123332 cites W2022245026 @default.
- W156123332 cites W2023554081 @default.
- W156123332 cites W2023805007 @default.
- W156123332 cites W2024903578 @default.
- W156123332 cites W2024972965 @default.
- W156123332 cites W2025998009 @default.
- W156123332 cites W2028689567 @default.
- W156123332 cites W2032039966 @default.
- W156123332 cites W2033363278 @default.
- W156123332 cites W2035212378 @default.
- W156123332 cites W2036564049 @default.
- W156123332 cites W2038556082 @default.
- W156123332 cites W2039075677 @default.
- W156123332 cites W2040391103 @default.
- W156123332 cites W2045039791 @default.
- W156123332 cites W2046163031 @default.
- W156123332 cites W2050277690 @default.
- W156123332 cites W2050571288 @default.
- W156123332 cites W2051588629 @default.
- W156123332 cites W2052370726 @default.
- W156123332 cites W2054633892 @default.
- W156123332 cites W2057423414 @default.
- W156123332 cites W2063553928 @default.
- W156123332 cites W2065153413 @default.
- W156123332 cites W2066003961 @default.
- W156123332 cites W2067506977 @default.
- W156123332 cites W2067754613 @default.
- W156123332 cites W2069421644 @default.