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- W1561279311 abstract "Thioacetamide, administered in a dose of 50/mg/kg for 9 days, produced a profound effect on the distribution and labeling of ribonucleic acid (RNA) of the rat liver. The amount of p -RNA (released by phenol into the aqueous phase) and r -RNA (which remained in the phenol), was increased two- to threefold in the nuclei. In the nucleoli, the amount of p -RNA was doubled, and the r -RNA was increased by a factor of 3.5. The amount of mitochondrial and microsomal RNA was correspondingly decreased, but the p -RNA of the cytoplasmic sap was increased. Thioacetamide suppressed the incorporation of orotic acid-2-C14 into the p - and r -RNA of the nuclei. As measured by specific activity, the labeling of nucleolar p -RNA was unchanged by thioacetamide. The labeling of the r -RNA of the nucleoli was suppressed by 30 per cent at early time points." @default.
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- W1561279311 date "1963-05-01" @default.
- W1561279311 modified "2023-09-23" @default.
- W1561279311 title "Effects of thioacetamide on incorporation of orotic acid-2-C14 into RNA fractions in liver." @default.
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