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- W1561295508 abstract "OBJECTIVE: We used serial optical coherence tomography (OCT) to assess the evolution of macular anatomy in papilledema patients. BACKGROUND: In eyes affected by papilledema, OCT quantifies retinal nerve fiber layer (RNFL) and optic nerve head (ONH) swelling. These improve over time with the underlying condition, sometimes revealing residual axonal loss. Parallel changes in the macula have not been well described. DESIGN/METHODS: We analyzed 40 eyes in 20 patients with optic disc edema associated with increased intracranial pressure (70% idiopathic intracranial hypertension), using spectral-domain OCT. Serial testing was conducted over 3-28 months (mean, 11 months). We measured the thickness and volume of the 6mm-diameter central retina and its individual layers and of the peripapillary RNFL and ONH. We excluded eyes with peripapillary intraretinal fluid or unrelated retinal pathology. RESULTS: Mean total macular volume (TMV) fell non-significantly from 8.38 to 8.23mm 3 in the group, usually in parallel with improvement of ONH and RNFL swelling. TMV fell by >0.08 mm 3 in 25 eyes, but only rose by this value in 2 eyes. Macular change was chiefly attributable to thinning of the RNFL, retinal ganglion cell (RGC) and inner plexiform layers. Four eyes from 2 patients with severe peripapillary RNFL loss showed gradual thickening of the inner nuclear layer (INL) associated with the formation of perifoveal microcysts. CONCLUSIONS: Mild macular thinning often accompanies the resolution of ONH and RNFL swelling in papilledema. This pattern suggests a transition from distended to normal or atrophic RCC axons and cell bodies. Microcystic macular edema originating in the INL in 2 patients was similar to that seen in multiple sclerosis and neuromyelitis optica. We conclude that this finding may sometimes be caused by neuronal loss rather than inflammation. Study Supported by: Not applicable. Disclosure: Dr. Villanueva has nothing to disclose. Dr. Abukhalil has nothing to disclose. Dr. Morrow has received research support from Novartis." @default.
- W1561295508 created "2016-06-24" @default.
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- W1561295508 date "2014-04-08" @default.
- W1561295508 modified "2023-09-24" @default.
- W1561295508 title "Evolution of Macular Findings on Optical Coherence Tomography (OCT) in Papilledema (P2.284)" @default.
- W1561295508 hasPublicationYear "2014" @default.
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