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- W1561395440 abstract "Abstract Increasing evidence indicates that modulation of Na + /K + ATPase activity is involved in forms of neuronal and synaptic plasticity. In tactile (T) neurons of the leech Hirudo medicinalis , Na + /K + ATPase is the main determinant of the afterhyperpolarization (AHP), which characterizes the firing of these mechanosensory neurons. Previously, it has been reported that cAMP (3′,5′‐cyclic adenosine monophosphate), which mediates the effects of serotonin (5HT) in some forms of learning in the leech, negatively modulates Na + /K + ATPase activity, thereby reducing the AHP amplitude in T neurons. Here, we show that a transient inhibition of Na + /K + ATPase can affect the synaptic connection between two ipsilateral T neurons. Bath application of 10 n m dihydroouabain (DHO), an ouabain analogue, causes an increase in the amplitude of the synaptic potential (SP) recorded in the postsynaptic element when a test stimulus is applied in the presynaptic neuron. Iontophoretic injection of cAMP into the presynaptic T neuron also produces an increase of SP. Simulations carried out by using a computational model of the T neuron suggest that a reduction of the pump rate and a consequent depression of the AHP might facilitate the conduction of action potentials to the synaptic terminals. Moreover, nearly intact leeches injected with 10 n m DHO respond with a swimming episode more quickly to an electrical stimulation, which selectively activates T neurons exhibiting sensitization of swimming induction. Collectively, our results show that inhibition of Na + /K + ATPase is critical for short‐term plasticity." @default.
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- W1561395440 date "2007-01-01" @default.
- W1561395440 modified "2023-10-15" @default.
- W1561395440 title "Inhibition of Na+/K+ ATPase potentiates synaptic transmission in tactile sensory neurons of the leech" @default.
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- W1561395440 doi "https://doi.org/10.1111/j.1460-9568.2006.05257.x" @default.
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