FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561666504> ?p ?o ?g. }

• W1561666504 endingPage "54" @default.
• W1561666504 startingPage "5248" @default.
• W1561666504 abstract "Although aberrant integrin expression has been documented in many epithelial tumors, little is known about how integrins influence neoplastic progression. To examine this issue, transgenic mice in which the alpha2beta1 or alpha3beta1 integrin was expressed in the suprabasal epidermal layers via the involucrin promoter were subjected to skin carcinogenesis. Equal numbers of benign squamous papillomas were observed in transgenic and wild-type animals. However, the frequency of conversion of papillomas to malignant squamous cell carcinomas was much lower in alpha3beta1 transgenic than in alpha2beta1 transgenic and wild-type mice. No differences were observed in apoptosis or in the expression of endogenous integrins in transgenic and wild-type papillomas. However, alpha3beta1 transgenic papillomas displayed a diminished proliferative capacity and were more highly differentiated as judged by BrdUrd incorporation and keratin 10 expression, respectively, than alpha2beta1 transgenic and wild-type papillomas. Two proteins that associate with alpha3beta1 and not alpha2beta1 are extracellular matrix metalloproteinase inducer and CD81. Extracellular matrix metalloproteinase inducer expression correlated inversely with the degree of differentiation in normal epidermis and in transgenic and wild-type papillomas. Up-regulation of CD81 was observed in 100% of wild-type and 88% of alpha2beta1 transgenic papillomas but in only 25% of alpha3beta1 transgenic papillomas. CD81 was undetectable in untreated epidermis and strongly expressed in all transgenic and wild-type squamous cell carcinomas. Our results demonstrate that the alpha3beta1 integrin can suppress malignant conversion, and that the mechanism may involve CD81." @default.
• W1561666504 created "2016-06-24" @default.
• W1561666504 creator A5068471552 @default.
• W1561666504 creator A5084576572 @default.
• W1561666504 date "2001-07-01" @default.
• W1561666504 modified "2023-09-23" @default.
• W1561666504 title "Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion." @default.
• W1561666504 cites W1512344444 @default.
• W1561666504 cites W1517196894 @default.
• W1561666504 cites W1563613529 @default.
• W1561666504 cites W1607562326 @default.
• W1561666504 cites W1895730431 @default.
• W1561666504 cites W1966865102 @default.
• W1561666504 cites W1968194439 @default.
• W1561666504 cites W1970858060 @default.
• W1561666504 cites W1972586003 @default.
• W1561666504 cites W1975718597 @default.
• W1561666504 cites W1980830316 @default.
• W1561666504 cites W1981188790 @default.
• W1561666504 cites W1981393628 @default.
• W1561666504 cites W1984833661 @default.
• W1561666504 cites W1986958075 @default.
• W1561666504 cites W1988232005 @default.
• W1561666504 cites W1997740904 @default.
• W1561666504 cites W2001296918 @default.
• W1561666504 cites W2002333365 @default.
• W1561666504 cites W2008360353 @default.
• W1561666504 cites W2009455337 @default.
• W1561666504 cites W2010571187 @default.
• W1561666504 cites W2026431103 @default.
• W1561666504 cites W2029231027 @default.
• W1561666504 cites W2041400374 @default.
• W1561666504 cites W2047051567 @default.
• W1561666504 cites W2053947462 @default.
• W1561666504 cites W2054400088 @default.
• W1561666504 cites W2055721324 @default.
• W1561666504 cites W2065818549 @default.
• W1561666504 cites W2068124694 @default.
• W1561666504 cites W2078478824 @default.
• W1561666504 cites W2086296240 @default.
• W1561666504 cites W2088060848 @default.
• W1561666504 cites W2120645308 @default.
• W1561666504 cites W2132414500 @default.
• W1561666504 cites W2134674137 @default.
• W1561666504 cites W2147767883 @default.
• W1561666504 cites W2151444080 @default.
• W1561666504 cites W2164767056 @default.
• W1561666504 cites W2248637620 @default.
• W1561666504 cites W2254322389 @default.
• W1561666504 cites W2970340375 @default.
• W1561666504 cites W81760698 @default.
• W1561666504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11431366" @default.
• W1561666504 hasPublicationYear "2001" @default.
• W1561666504 type Work @default.
• W1561666504 sameAs 1561666504 @default.
• W1561666504 citedByCount "15" @default.
• W1561666504 countsByYear W15616665042012 @default.
• W1561666504 countsByYear W15616665042014 @default.
• W1561666504 countsByYear W15616665042015 @default.
• W1561666504 countsByYear W15616665042023 @default.
• W1561666504 crossrefType "journal-article" @default.
• W1561666504 hasAuthorship W1561666504A5068471552 @default.
• W1561666504 hasAuthorship W1561666504A5084576572 @default.
• W1561666504 hasConcept C102230213 @default.
• W1561666504 hasConcept C104317684 @default.
• W1561666504 hasConcept C105702510 @default.
• W1561666504 hasConcept C121608353 @default.
• W1561666504 hasConcept C141035611 @default.
• W1561666504 hasConcept C143065580 @default.
• W1561666504 hasConcept C1491633281 @default.
• W1561666504 hasConcept C195687474 @default.
• W1561666504 hasConcept C207583985 @default.
• W1561666504 hasConcept C2776458125 @default.
• W1561666504 hasConcept C2777074287 @default.
• W1561666504 hasConcept C2777577635 @default.
• W1561666504 hasConcept C502942594 @default.
• W1561666504 hasConcept C54355233 @default.
• W1561666504 hasConcept C555283112 @default.
• W1561666504 hasConcept C81885089 @default.
• W1561666504 hasConcept C86803240 @default.
• W1561666504 hasConcept C95444343 @default.
• W1561666504 hasConceptScore W1561666504C102230213 @default.
• W1561666504 hasConceptScore W1561666504C104317684 @default.
• W1561666504 hasConceptScore W1561666504C105702510 @default.
• W1561666504 hasConceptScore W1561666504C121608353 @default.
• W1561666504 hasConceptScore W1561666504C141035611 @default.
• W1561666504 hasConceptScore W1561666504C143065580 @default.
• W1561666504 hasConceptScore W1561666504C1491633281 @default.
• W1561666504 hasConceptScore W1561666504C195687474 @default.
• W1561666504 hasConceptScore W1561666504C207583985 @default.
• W1561666504 hasConceptScore W1561666504C2776458125 @default.
• W1561666504 hasConceptScore W1561666504C2777074287 @default.
• W1561666504 hasConceptScore W1561666504C2777577635 @default.
• W1561666504 hasConceptScore W1561666504C502942594 @default.
• W1561666504 hasConceptScore W1561666504C54355233 @default.
• W1561666504 hasConceptScore W1561666504C555283112 @default.
• W1561666504 hasConceptScore W1561666504C81885089 @default.
• W1561666504 hasConceptScore W1561666504C86803240 @default.

• next