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• W1561672023 endingPage "4405" @default.
• W1561672023 startingPage "4399" @default.
• W1561672023 abstract "Abstract The leukocyte-specific integrin, LFA-1, can enhance T cell activation. However, it is unclear whether the binding of LFA-1 to its ligand, ICAM-1, functions through intercellular adhesion alone, resulting in an augmentation of the TCR signal, or involves an additional LFA-1-mediated cellular signal transduction pathway. We have previously shown that naive CD4+ lymph node T cells, isolated from DO11.10 TCR transgenic mice, are activated by increasing doses of exogenous OVA peptide presented by transfectants expressing both class II and ICAM-1, but not by cells expressing class II alone. To determine whether LFA-1/ICAM-1 interactions were simply enhancing the presentation of low concentrations of specific MHC/peptide complexes generated from exogenously added peptide, we transfected cells with class II that is covalently coupled to peptide, alone or in combination with ICAM-1. These cells express 100-fold more specific class II/peptide complexes than can be loaded onto class II-positive cells at maximum concentrations of exogenous peptide. Despite this high density of TCR ligand, activation of naive CD4+ T cells still requires the coexpression of ICAM-1. LFA-1/ICAM-1 interactions are not required for effective conjugate formation and TCR engagement because presentation of class II/peptide complexes in the absence of ICAM-1 does induce up-regulation of CD25 and CD69. Thus, high numbers of engaged TCR cannot compensate for the lack of LFA-1/ICAM-1 interactions in the activation of naive CD4+ T cells." @default.
• W1561672023 created "2016-06-24" @default.
• W1561672023 creator A5053130869 @default.
• W1561672023 creator A5078953147 @default.
• W1561672023 creator A5080459091 @default.
• W1561672023 date "1999-04-15" @default.
• W1561672023 modified "2023-10-14" @default.
• W1561672023 title "The Dependence for Leukocyte Function-Associated Antigen-1/ICAM-1 Interactions in T Cell Activation Cannot Be Overcome by Expression of High Density TCR Ligand" @default.
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• W1561672023 doi "https://doi.org/10.4049/jimmunol.162.8.4399" @default.
• W1561672023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10201975" @default.
• W1561672023 hasPublicationYear "1999" @default.
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