FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561708153> ?p ?o ?g. }

• W1561708153 endingPage "5722" @default.
• W1561708153 startingPage "5710" @default.
• W1561708153 abstract "The interaction of proteinase inhibitors produced, in most cases, by host organisms and the invasive proteinases of pathogens or parasites or the dietary proteinases of predators, results in an evolutionary 'arms race' of rapid and ongoing change in both interacting proteins. The importance of these interactions in pathogenicity and predation is indicated by the high level and diversity of observable evolutionary activity that has been found. At the initial level of evolutionary change, recruitment of other functional protein-folding families has occurred, with the more recent evolution of one class of proteinase inhibitor from another, using the same mechanism and proteinase contact residues. The combination of different inhibitor domains into a single molecule is also observed. The basis from which variation is possible is shown by the high rate of retention of gene duplication events and by the associated process of inhibitory domain multiplication. At this level of reorganization, mutually exclusive splicing is also observed. Finally, the major mechanism by which variation is achieved rapidly is hypervariation of contact residues, an almost ubiquitous feature of proteinase inhibitors. The diversity of evolutionary mechanisms in a single class of proteins is unlikely to be common, because few systems are under similar pressure to create variation. Proteinase inhibitors are therefore a potential model system in which to study basic evolutionary process such as functional diversification." @default.
• W1561708153 created "2016-06-24" @default.
• W1561708153 creator A5091297644 @default.
• W1561708153 date "2005-10-17" @default.
• W1561708153 modified "2023-09-26" @default.
• W1561708153 title "Evolutionary mechanisms acting on proteinase inhibitor variability" @default.
• W1561708153 cites W1488019139 @default.
• W1561708153 cites W1490005269 @default.
• W1561708153 cites W1493993231 @default.
• W1561708153 cites W1531754583 @default.
• W1561708153 cites W1540913060 @default.
• W1561708153 cites W1543457854 @default.
• W1561708153 cites W1553626787 @default.
• W1561708153 cites W1561454246 @default.
• W1561708153 cites W1565811769 @default.
• W1561708153 cites W1579109316 @default.
• W1561708153 cites W1584173134 @default.
• W1561708153 cites W1597797344 @default.
• W1561708153 cites W1642540132 @default.
• W1561708153 cites W1796079077 @default.
• W1561708153 cites W1831777278 @default.
• W1561708153 cites W1900297589 @default.
• W1561708153 cites W1915478014 @default.
• W1561708153 cites W1921779724 @default.
• W1561708153 cites W1926946171 @default.
• W1561708153 cites W1964399899 @default.
• W1561708153 cites W1965320478 @default.
• W1561708153 cites W1966307010 @default.
• W1561708153 cites W1967209412 @default.
• W1561708153 cites W1968854469 @default.
• W1561708153 cites W1969197272 @default.
• W1561708153 cites W1971661596 @default.
• W1561708153 cites W1973747874 @default.
• W1561708153 cites W1974980316 @default.
• W1561708153 cites W1976622611 @default.
• W1561708153 cites W1978775895 @default.
• W1561708153 cites W1979630324 @default.
• W1561708153 cites W1979885427 @default.
• W1561708153 cites W1980996405 @default.
• W1561708153 cites W1981673754 @default.
• W1561708153 cites W1981708779 @default.
• W1561708153 cites W1984061214 @default.
• W1561708153 cites W1984752917 @default.
• W1561708153 cites W1985542290 @default.
• W1561708153 cites W1985886278 @default.
• W1561708153 cites W1986045862 @default.
• W1561708153 cites W1988235895 @default.
• W1561708153 cites W1988542675 @default.
• W1561708153 cites W1988591865 @default.
• W1561708153 cites W1991475211 @default.
• W1561708153 cites W1991498030 @default.
• W1561708153 cites W2000377676 @default.
• W1561708153 cites W2001142234 @default.
• W1561708153 cites W2003061649 @default.
• W1561708153 cites W2005057056 @default.
• W1561708153 cites W2006725068 @default.
• W1561708153 cites W2010689661 @default.
• W1561708153 cites W2011479978 @default.
• W1561708153 cites W2012543140 @default.
• W1561708153 cites W2014585251 @default.
• W1561708153 cites W2019462474 @default.
• W1561708153 cites W2019610850 @default.
• W1561708153 cites W2021569695 @default.
• W1561708153 cites W2022404008 @default.
• W1561708153 cites W2024297705 @default.
• W1561708153 cites W2025504748 @default.
• W1561708153 cites W2028788041 @default.
• W1561708153 cites W2029357933 @default.
• W1561708153 cites W2031129962 @default.
• W1561708153 cites W2031285419 @default.
• W1561708153 cites W2032615313 @default.
• W1561708153 cites W2033641220 @default.
• W1561708153 cites W2035073388 @default.
• W1561708153 cites W2035567217 @default.
• W1561708153 cites W2035942843 @default.
• W1561708153 cites W2036828042 @default.
• W1561708153 cites W2037547753 @default.
• W1561708153 cites W2040236473 @default.
• W1561708153 cites W2040295790 @default.
• W1561708153 cites W2040888268 @default.
• W1561708153 cites W2041963246 @default.
• W1561708153 cites W2042497267 @default.
• W1561708153 cites W2042744884 @default.
• W1561708153 cites W2045090247 @default.
• W1561708153 cites W2048188238 @default.
• W1561708153 cites W2049327565 @default.
• W1561708153 cites W2050450208 @default.
• W1561708153 cites W2051973889 @default.
• W1561708153 cites W2059117640 @default.
• W1561708153 cites W2061465029 @default.
• W1561708153 cites W2061524488 @default.
• W1561708153 cites W2063894680 @default.
• W1561708153 cites W2064674351 @default.
• W1561708153 cites W2065474276 @default.
• W1561708153 cites W2065546035 @default.
• W1561708153 cites W2067279802 @default.
• W1561708153 cites W2067834876 @default.
• W1561708153 cites W2067842847 @default.

• next