FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561804426> ?p ?o ?g. }

• W1561804426 abstract "Activator protein 2α (AP-2α) belongs to the AP-2 family of transcription factors that are involved in the regulation of cell proliferation, differentiation, apoptosis and carcinogenesis and has been suggested to function as a tumor suppressor in many cancers. However, the physiological role of AP-2α in hepatocytes is unknown. The present study is to characterize the expression and function of AP-2α in the liver of conscience mouse. Exogenous AP-2α was overexpressed in the mouse liver by in vivo gene delivery and changes in transcription factor expression were identified by using protein-DNA arrays and immunoblotting. Western blotting and protein/DNA arrays showed that AP-2α is expressed in the nuclei of mouse hepatocytes. Overexpression of AP-2αin vivo significantly suppressed transcription factors AP-1, CREB and c-Myc, and markedly increased CBF, c-Myb, NF-1, Pax-5, RXR, Smad3/4, TR(DR-4), USF-1 and GATA. Among all GATA proteins, only GATA-4 level was dramatically elevated and there was a concomitant loss of phospho-GATA-4. Corresponding changes were detected in upstream kinases Akt, GSK-3β and PKA, which regulates the phosphorylation status and stability of GATA-4 protein. AP-2α is expressed in mouse hepatocytes and it acts as a master regulator of numerous transcription factors in the liver." @default.
• W1561804426 created "2016-06-24" @default.
• W1561804426 creator A5057623968 @default.
• W1561804426 creator A5078788033 @default.
• W1561804426 creator A5078951724 @default.
• W1561804426 creator A5082820494 @default.
• W1561804426 date "2011-06-17" @default.
• W1561804426 modified "2023-09-23" @default.
• W1561804426 title "Activator protein-2α functions as a master regulator of multiple transcription factors in the mouse liver" @default.
• W1561804426 cites W1507143828 @default.
• W1561804426 cites W1545443160 @default.
• W1561804426 cites W1860599747 @default.
• W1561804426 cites W192718590 @default.
• W1561804426 cites W1974658675 @default.
• W1561804426 cites W1978125302 @default.
• W1561804426 cites W1982143720 @default.
• W1561804426 cites W1984253873 @default.
• W1561804426 cites W1997791083 @default.
• W1561804426 cites W2002856679 @default.
• W1561804426 cites W2004433270 @default.
• W1561804426 cites W2006045768 @default.
• W1561804426 cites W2007642552 @default.
• W1561804426 cites W2010324176 @default.
• W1561804426 cites W2019127826 @default.
• W1561804426 cites W2020847482 @default.
• W1561804426 cites W2029787649 @default.
• W1561804426 cites W2035209944 @default.
• W1561804426 cites W2039639864 @default.
• W1561804426 cites W2045545244 @default.
• W1561804426 cites W2045934284 @default.
• W1561804426 cites W2058849934 @default.
• W1561804426 cites W2061484837 @default.
• W1561804426 cites W2061965892 @default.
• W1561804426 cites W2076912135 @default.
• W1561804426 cites W2081928213 @default.
• W1561804426 cites W2090036710 @default.
• W1561804426 cites W2097796945 @default.
• W1561804426 cites W2120966823 @default.
• W1561804426 cites W2131838602 @default.
• W1561804426 cites W2145527883 @default.
• W1561804426 cites W2159996969 @default.
• W1561804426 cites W2165812499 @default.
• W1561804426 cites W2239490943 @default.
• W1561804426 cites W2090764679 @default.
• W1561804426 doi "https://doi.org/10.1111/j.1872-034x.2011.00827.x" @default.
• W1561804426 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4139281" @default.
• W1561804426 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21682828" @default.
• W1561804426 hasPublicationYear "2011" @default.
• W1561804426 type Work @default.
• W1561804426 sameAs 1561804426 @default.
• W1561804426 citedByCount "5" @default.
• W1561804426 countsByYear W15618044262013 @default.
• W1561804426 countsByYear W15618044262015 @default.
• W1561804426 countsByYear W15618044262017 @default.
• W1561804426 crossrefType "journal-article" @default.
• W1561804426 hasAuthorship W1561804426A5057623968 @default.
• W1561804426 hasAuthorship W1561804426A5078788033 @default.
• W1561804426 hasAuthorship W1561804426A5078951724 @default.
• W1561804426 hasAuthorship W1561804426A5082820494 @default.
• W1561804426 hasBestOaLocation W15618044262 @default.
• W1561804426 hasConcept C104317684 @default.
• W1561804426 hasConcept C11960822 @default.
• W1561804426 hasConcept C138885662 @default.
• W1561804426 hasConcept C153911025 @default.
• W1561804426 hasConcept C1629964 @default.
• W1561804426 hasConcept C179926584 @default.
• W1561804426 hasConcept C183022183 @default.
• W1561804426 hasConcept C41895202 @default.
• W1561804426 hasConcept C502942594 @default.
• W1561804426 hasConcept C54355233 @default.
• W1561804426 hasConcept C555283112 @default.
• W1561804426 hasConcept C62794011 @default.
• W1561804426 hasConcept C6929976 @default.
• W1561804426 hasConcept C86339819 @default.
• W1561804426 hasConcept C86803240 @default.
• W1561804426 hasConcept C88045685 @default.
• W1561804426 hasConcept C95444343 @default.
• W1561804426 hasConceptScore W1561804426C104317684 @default.
• W1561804426 hasConceptScore W1561804426C11960822 @default.
• W1561804426 hasConceptScore W1561804426C138885662 @default.
• W1561804426 hasConceptScore W1561804426C153911025 @default.
• W1561804426 hasConceptScore W1561804426C1629964 @default.
• W1561804426 hasConceptScore W1561804426C179926584 @default.
• W1561804426 hasConceptScore W1561804426C183022183 @default.
• W1561804426 hasConceptScore W1561804426C41895202 @default.
• W1561804426 hasConceptScore W1561804426C502942594 @default.
• W1561804426 hasConceptScore W1561804426C54355233 @default.
• W1561804426 hasConceptScore W1561804426C555283112 @default.
• W1561804426 hasConceptScore W1561804426C62794011 @default.
• W1561804426 hasConceptScore W1561804426C6929976 @default.
• W1561804426 hasConceptScore W1561804426C86339819 @default.
• W1561804426 hasConceptScore W1561804426C86803240 @default.
• W1561804426 hasConceptScore W1561804426C88045685 @default.
• W1561804426 hasConceptScore W1561804426C95444343 @default.
• W1561804426 hasLocation W15618044261 @default.
• W1561804426 hasLocation W15618044262 @default.
• W1561804426 hasLocation W15618044263 @default.
• W1561804426 hasLocation W15618044264 @default.
• W1561804426 hasOpenAccess W1561804426 @default.
• W1561804426 hasPrimaryLocation W15618044261 @default.

• next