FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561807211> ?p ?o ?g. }

• W1561807211 abstract "Decoctions and infusions of Artocarpus communis (Forst.) (family: Moraceae) root-bark are commonly used traditionally among the Yoruba-speaking people of Western Nigeria as folk remedies for the management, control and/or treatment of an array of human diseases, including type 2, adult-onset diabetes mellitus. Although numerous bioactive flavonoids have been isolated from the roots, stem-bark and leaves of A. communis, to the best of our knowledge, the effects of the plant's root-bark extract on animal model of diabetes mellitus and on liver tissues have hitherto, not been reported in the biomedical literature. In view of this, the present study was undertaken to investigate the glycaemic effect of, and hepatic tissue ultrastructural, morphological and metabolic changes induced by A. communis root-bark aqueous extract (ACE) in Wistar rats. The ultrastructural, morphological and metabolic effects of ACE have been compared with those induced by streptozotocin (STZ) in rat experimental paradigms. Four groups (A, B, C and D) of Wistar rats, each group containing 10 rats, were used. Diabetes mellitus was induced in the diabetic groups B and C animals by intraperitoneal injections of STZ (75 mg/kg body weight), while group A rats received A. communis root-bark aqueous extract (ACE, 100 mg/kg body weight, i.p.) alone. Control group D rats received distilled water in quantities equivalent to the volume of ACE administered intraperitoneally. The rats in group C were additionally treated with ACE (100 mg/kg body weight i. p.) daily from day 3 to day 10 after STZ treatment. Hepatic glucokinase, hexokinase, glutamate dehydrogenase, succinate dehydrogenase, beta-hydroxybutyrate dehydrogenase, serum insulin and blood glucose levels of the animals were measured and recorded before and after ACE, STZ and STZ+ACE treatments. Hepatic tissues were also processed for transmission electron microscopy. Electron microscopic examinations showed toxic, deleterious alterations in the ultrastructures of groups A, B and C hepatic cells, the most prominent deleterious effects being on the hepatocytes. Ultrastructural changes observed within the hepatocytes of groups A, B and C rats include disrupted mitochondria with increase in lipid droplets, extensive hepatocellular vacuolation, scanty rough endoplasmic reticulum (RER) and ribosomes. Large glycogen clusters were also noticed displacing the mitochondria and RER in group A rats. Group A rats also developed significant hyperglycemia (p<0.05) immediately after ACE administration, while groups B and C rats developed hyperglycemia 24 hours after STZ treatment. When compared with the control group D rats, the activities of all the three subsystems were disrupted, leading to overall inhibition of oxidative phosphorylation of the liver mitochondria in groups A, B and C rats, but remain normal in the untreated group D control rats. The findings of the present study indicate that A. communis root-bark aqueous extract induces hyperglycaemia in the experimental animal model used, and that the plant's extract disrupts the ultrastructural characteristics and architecture of hepatocytes as well as oxidative energy metabolism." @default.
• W1561807211 created "2016-06-24" @default.
• W1561807211 creator A5008981627 @default.
• W1561807211 creator A5034425791 @default.
• W1561807211 date "2007-06-10" @default.
• W1561807211 modified "2023-09-23" @default.
• W1561807211 title "Artocarpus communis Forst. root-bark aqueous extract- and streptozotocin-induced ultrastructural and metabolic changes in hepatic tissues of Wistar rats." @default.
• W1561807211 cites W1504551253 @default.
• W1561807211 cites W1556704697 @default.
• W1561807211 cites W1567614586 @default.
• W1561807211 cites W1775749144 @default.
• W1561807211 cites W1892344960 @default.
• W1561807211 cites W1920934057 @default.
• W1561807211 cites W1964994058 @default.
• W1561807211 cites W1969191668 @default.
• W1561807211 cites W1995464415 @default.
• W1561807211 cites W2004683253 @default.
• W1561807211 cites W2019126938 @default.
• W1561807211 cites W2024020163 @default.
• W1561807211 cites W2029918421 @default.
• W1561807211 cites W2031214222 @default.
• W1561807211 cites W2042464457 @default.
• W1561807211 cites W2064943977 @default.
• W1561807211 cites W2065990183 @default.
• W1561807211 cites W2090402455 @default.
• W1561807211 cites W2094887082 @default.
• W1561807211 cites W2109858658 @default.
• W1561807211 cites W2112040506 @default.
• W1561807211 cites W2156044622 @default.
• W1561807211 cites W2157712434 @default.
• W1561807211 cites W2183021025 @default.
• W1561807211 cites W2220114233 @default.
• W1561807211 cites W2263947079 @default.
• W1561807211 cites W2285032515 @default.
• W1561807211 cites W2333302658 @default.
• W1561807211 cites W2335448640 @default.
• W1561807211 cites W2399610112 @default.
• W1561807211 cites W3114713417 @default.
• W1561807211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2816511" @default.
• W1561807211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20161908" @default.
• W1561807211 hasPublicationYear "2007" @default.
• W1561807211 type Work @default.
• W1561807211 sameAs 1561807211 @default.
• W1561807211 citedByCount "5" @default.
• W1561807211 countsByYear W15618072112015 @default.
• W1561807211 countsByYear W15618072112019 @default.
• W1561807211 countsByYear W15618072112020 @default.
• W1561807211 countsByYear W15618072112021 @default.
• W1561807211 crossrefType "journal-article" @default.
• W1561807211 hasAuthorship W1561807211A5008981627 @default.
• W1561807211 hasAuthorship W1561807211A5034425791 @default.
• W1561807211 hasConcept C133446333 @default.
• W1561807211 hasConcept C134018914 @default.
• W1561807211 hasConcept C142724271 @default.
• W1561807211 hasConcept C185592680 @default.
• W1561807211 hasConcept C18903297 @default.
• W1561807211 hasConcept C190409667 @default.
• W1561807211 hasConcept C2779280383 @default.
• W1561807211 hasConcept C2779429693 @default.
• W1561807211 hasConcept C2780255822 @default.
• W1561807211 hasConcept C2780306569 @default.
• W1561807211 hasConcept C43617362 @default.
• W1561807211 hasConcept C555293320 @default.
• W1561807211 hasConcept C556039675 @default.
• W1561807211 hasConcept C71924100 @default.
• W1561807211 hasConcept C86803240 @default.
• W1561807211 hasConcept C87555872 @default.
• W1561807211 hasConcept C98274493 @default.
• W1561807211 hasConceptScore W1561807211C133446333 @default.
• W1561807211 hasConceptScore W1561807211C134018914 @default.
• W1561807211 hasConceptScore W1561807211C142724271 @default.
• W1561807211 hasConceptScore W1561807211C185592680 @default.
• W1561807211 hasConceptScore W1561807211C18903297 @default.
• W1561807211 hasConceptScore W1561807211C190409667 @default.
• W1561807211 hasConceptScore W1561807211C2779280383 @default.
• W1561807211 hasConceptScore W1561807211C2779429693 @default.
• W1561807211 hasConceptScore W1561807211C2780255822 @default.
• W1561807211 hasConceptScore W1561807211C2780306569 @default.
• W1561807211 hasConceptScore W1561807211C43617362 @default.
• W1561807211 hasConceptScore W1561807211C555293320 @default.
• W1561807211 hasConceptScore W1561807211C556039675 @default.
• W1561807211 hasConceptScore W1561807211C71924100 @default.
• W1561807211 hasConceptScore W1561807211C86803240 @default.
• W1561807211 hasConceptScore W1561807211C87555872 @default.
• W1561807211 hasConceptScore W1561807211C98274493 @default.
• W1561807211 hasLocation W15618072111 @default.
• W1561807211 hasOpenAccess W1561807211 @default.
• W1561807211 hasPrimaryLocation W15618072111 @default.
• W1561807211 hasRelatedWork W1984793415 @default.
• W1561807211 hasRelatedWork W2056841709 @default.
• W1561807211 hasRelatedWork W2079311496 @default.
• W1561807211 hasRelatedWork W2086247703 @default.
• W1561807211 hasRelatedWork W211873287 @default.
• W1561807211 hasRelatedWork W2129019848 @default.
• W1561807211 hasRelatedWork W2130363888 @default.
• W1561807211 hasRelatedWork W2228317643 @default.
• W1561807211 hasRelatedWork W2273964303 @default.
• W1561807211 hasRelatedWork W2282177879 @default.
• W1561807211 hasRelatedWork W2289621622 @default.
• W1561807211 hasRelatedWork W2383398771 @default.

• next