Matches in SemOpenAlex for { <https://semopenalex.org/work/W1561837013> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1561837013 abstract "Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CAThe fundamental premise of allogeneic vaccines for cancer relies upon the presence of common antigens that are shared between established cell lines and a large proportion of patients with histologically related tumors. Recent results from The Cancer Genome Atlas have clearly demonstrated that somatic mutations in exon region DNA, while potentially immunogenic, do not result in the translation of antigenic proteins that are similar from patient to patient. Instead, these data reinforce the concept that dysregulation of common pathways contributes to the general property of de-differentiation in tumor cells and the acquisition of immature phenotypes as compared to untransformed precursor cells. This phenomenon leads to expression of mucinous and embryonal antigens, collectively known as cancer testis antigens, that are otherwise rare in mature tissues and to which central tolerance remains incomplete. We have developed allogeneic vaccines based on parallel screening of non-small cell lung, bladder, triple-negative breast, ovarian and melanoma tumor cell lines and patient tumor samples. The baseline expression of certain antigens, including SSX2, SSX4, CT10, MAGE-A1, MAGE-A10, LAGE-1 and NY-ESO-1 was found to vary widely both between tumor samples and non-transformed tissue controls. Among all antigens screened, MAGE-A3 was most commonly upregulated across transformed tissue samples, however other antigens including BAGE-1, XAGE-1b and MAGE-A10 were found to be most dramatically upregulated. This analysis provides a screening tool with which to appropriately profile and prioritize individual cell lines for vaccine development in histologically diverse tumor types.Citation Format: Vadim V. Deyev, Neal Schilling, Taylor H. Schreiber. Allogeneic cell cased vaccine development by shared antigen screening. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2811. doi:10.1158/1538-7445.AM2014-2811" @default.
- W1561837013 created "2016-06-24" @default.
- W1561837013 creator A5001670202 @default.
- W1561837013 creator A5041398079 @default.
- W1561837013 creator A5055329103 @default.
- W1561837013 date "2014-09-30" @default.
- W1561837013 modified "2023-09-27" @default.
- W1561837013 title "Abstract 2811: Allogeneic cell cased vaccine development by shared antigen screening" @default.
- W1561837013 doi "https://doi.org/10.1158/1538-7445.am2014-2811" @default.
- W1561837013 hasPublicationYear "2014" @default.
- W1561837013 type Work @default.
- W1561837013 sameAs 1561837013 @default.
- W1561837013 citedByCount "0" @default.
- W1561837013 crossrefType "proceedings-article" @default.
- W1561837013 hasAuthorship W1561837013A5001670202 @default.
- W1561837013 hasAuthorship W1561837013A5041398079 @default.
- W1561837013 hasAuthorship W1561837013A5055329103 @default.
- W1561837013 hasConcept C104317684 @default.
- W1561837013 hasConcept C121608353 @default.
- W1561837013 hasConcept C134305767 @default.
- W1561837013 hasConcept C147483822 @default.
- W1561837013 hasConcept C203014093 @default.
- W1561837013 hasConcept C502942594 @default.
- W1561837013 hasConcept C54355233 @default.
- W1561837013 hasConcept C71924100 @default.
- W1561837013 hasConcept C86803240 @default.
- W1561837013 hasConceptScore W1561837013C104317684 @default.
- W1561837013 hasConceptScore W1561837013C121608353 @default.
- W1561837013 hasConceptScore W1561837013C134305767 @default.
- W1561837013 hasConceptScore W1561837013C147483822 @default.
- W1561837013 hasConceptScore W1561837013C203014093 @default.
- W1561837013 hasConceptScore W1561837013C502942594 @default.
- W1561837013 hasConceptScore W1561837013C54355233 @default.
- W1561837013 hasConceptScore W1561837013C71924100 @default.
- W1561837013 hasConceptScore W1561837013C86803240 @default.
- W1561837013 hasLocation W15618370131 @default.
- W1561837013 hasOpenAccess W1561837013 @default.
- W1561837013 hasPrimaryLocation W15618370131 @default.
- W1561837013 hasRelatedWork W1598446361 @default.
- W1561837013 hasRelatedWork W1925309346 @default.
- W1561837013 hasRelatedWork W1975341584 @default.
- W1561837013 hasRelatedWork W1983109464 @default.
- W1561837013 hasRelatedWork W1994189198 @default.
- W1561837013 hasRelatedWork W2025563905 @default.
- W1561837013 hasRelatedWork W2080401629 @default.
- W1561837013 hasRelatedWork W2118671300 @default.
- W1561837013 hasRelatedWork W2132690014 @default.
- W1561837013 hasRelatedWork W2136267518 @default.
- W1561837013 hasRelatedWork W2137088550 @default.
- W1561837013 hasRelatedWork W2209079748 @default.
- W1561837013 hasRelatedWork W2321662379 @default.
- W1561837013 hasRelatedWork W2338968994 @default.
- W1561837013 hasRelatedWork W2415034323 @default.
- W1561837013 hasRelatedWork W2885676221 @default.
- W1561837013 hasRelatedWork W2945346075 @default.
- W1561837013 hasRelatedWork W3030187827 @default.
- W1561837013 hasRelatedWork W2182708995 @default.
- W1561837013 hasRelatedWork W2737548101 @default.
- W1561837013 isParatext "false" @default.
- W1561837013 isRetracted "false" @default.
- W1561837013 magId "1561837013" @default.
- W1561837013 workType "article" @default.