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- W1562045326 abstract "We investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (i.c.v.) injection of ramipril (1 microgram/microliter) significantly reduced drinking in response to subcutaneous (s.c.) injection of isoprenaline (100 micrograms/kg) from 8.49 +/- 0.69 to 2.96 +/- 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 +/- 2.20 to 1.6 +/- 0.34 ml/2 h or water deprivation for 24 h from 12.61 +/- 0.83 to 5.10 +/- 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCI). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested." @default.
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- W1562045326 date "1994-12-01" @default.
- W1562045326 modified "2023-10-18" @default.
- W1562045326 title "Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli." @default.
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