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- W156210519 abstract "Laron syndrome (LS, congenital primary GH insensitivity) is caused by deletions or mutations in the GH receptor gene, resulting in an inability to generate insulin-like growth factor-I (IGF-I). If untreated, the deficiency of IGF-I results in severe dwarfism, as well as skeletal and muscular underdevelopment. The only treatment is the daily administration of recombinant IGF-I. This review summarizes the present experience by several groups worldwide. The main conclusions are: A. The one or two injections regimen result in the same growth velocity; B. The growth velocity obtained with IGF-I administration is smaller than that observed with hGH in children with congenital isolated GH deficiency; C. Overdosage of IGF-I causes a series of adverse effects which can be avoided by carefully monitoring the serum IGF-I and GH levels." @default.
- W156210519 created "2016-06-24" @default.
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- W156210519 date "2008-03-01" @default.
- W156210519 modified "2023-09-23" @default.
- W156210519 title "Insulin-like growth factor-I treatment of children with Laron syndrome (primary growth hormone insensitivity)." @default.
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