Matches in SemOpenAlex for { <https://semopenalex.org/work/W1562111343> ?p ?o ?g. }
- W1562111343 endingPage "53" @default.
- W1562111343 startingPage "40" @default.
- W1562111343 abstract "The development of presbycusis, or age-related hearing loss, is determined by a combination of genetic and environmental factors. The auditory periphery exhibits a progressive bilateral, symmetrical reduction of auditory sensitivity to sound from high to low frequencies. The central auditory nervous system shows symptoms of decline in age-related cognitive abilities, including difficulties in speech discrimination and reduced central auditory processing, ultimately resulting in auditory perceptual abnormalities. The pathophysiological mechanisms of presbycusis include excitotoxicity, oxidative stress, inflammation, aging and oxidative stress-induced DNA damage that results in apoptosis in the auditory pathway. However, the originating signals that trigger these mechanisms remain unclear. For instance, it is still unknown whether insulin is involved in auditory aging. Auditory aging has preclinical lesions, which manifest as asymptomatic loss of periphery auditory nerves and changes in the plasticity of the central auditory nervous system. Currently, the diagnosis of preclinical, reversible lesions depends on the detection of auditory impairment by functional imaging, and the identification of physiological and molecular biological markers. However, despite recent improvements in the application of these markers, they remain under-utilized in clinical practice. The application of antisenescent approaches to the prevention of auditory aging has produced inconsistent results. Future research will focus on the identification of markers for the diagnosis of preclinical auditory aging and the development of effective interventions. Geriatr Gerontol Int 2014; 14: 40–53." @default.
- W1562111343 created "2016-06-24" @default.
- W1562111343 creator A5014443045 @default.
- W1562111343 creator A5069579263 @default.
- W1562111343 creator A5081201122 @default.
- W1562111343 creator A5085880446 @default.
- W1562111343 date "2013-08-29" @default.
- W1562111343 modified "2023-09-26" @default.
- W1562111343 title "Current status of auditory aging and anti-aging research" @default.
- W1562111343 cites W1750764013 @default.
- W1562111343 cites W1813981721 @default.
- W1562111343 cites W1964120486 @default.
- W1562111343 cites W1964248735 @default.
- W1562111343 cites W1964393390 @default.
- W1562111343 cites W1965458458 @default.
- W1562111343 cites W1966783142 @default.
- W1562111343 cites W1973941114 @default.
- W1562111343 cites W1988408253 @default.
- W1562111343 cites W1989477058 @default.
- W1562111343 cites W1990254682 @default.
- W1562111343 cites W1990549525 @default.
- W1562111343 cites W1992433941 @default.
- W1562111343 cites W1995055754 @default.
- W1562111343 cites W1996286939 @default.
- W1562111343 cites W2002331408 @default.
- W1562111343 cites W2005422662 @default.
- W1562111343 cites W2006262937 @default.
- W1562111343 cites W2006334046 @default.
- W1562111343 cites W2007052546 @default.
- W1562111343 cites W2007203304 @default.
- W1562111343 cites W2014705874 @default.
- W1562111343 cites W2017073774 @default.
- W1562111343 cites W2017303317 @default.
- W1562111343 cites W2017994420 @default.
- W1562111343 cites W2023706424 @default.
- W1562111343 cites W2026067594 @default.
- W1562111343 cites W2026627305 @default.
- W1562111343 cites W2034923684 @default.
- W1562111343 cites W2037022511 @default.
- W1562111343 cites W2042669518 @default.
- W1562111343 cites W2044478811 @default.
- W1562111343 cites W2048356157 @default.
- W1562111343 cites W2048376025 @default.
- W1562111343 cites W2050083369 @default.
- W1562111343 cites W2050642282 @default.
- W1562111343 cites W2053591294 @default.
- W1562111343 cites W2057663429 @default.
- W1562111343 cites W2058972410 @default.
- W1562111343 cites W2063062036 @default.
- W1562111343 cites W2067368517 @default.
- W1562111343 cites W2067798364 @default.
- W1562111343 cites W2067874044 @default.
- W1562111343 cites W2069269881 @default.
- W1562111343 cites W2078045632 @default.
- W1562111343 cites W2082029677 @default.
- W1562111343 cites W2088636828 @default.
- W1562111343 cites W2091612516 @default.
- W1562111343 cites W2092284960 @default.
- W1562111343 cites W2095786576 @default.
- W1562111343 cites W2097498366 @default.
- W1562111343 cites W2101580126 @default.
- W1562111343 cites W2102180389 @default.
- W1562111343 cites W2105565496 @default.
- W1562111343 cites W2108398795 @default.
- W1562111343 cites W2110252452 @default.
- W1562111343 cites W2115220861 @default.
- W1562111343 cites W2118337397 @default.
- W1562111343 cites W2122426201 @default.
- W1562111343 cites W2131040638 @default.
- W1562111343 cites W2131736818 @default.
- W1562111343 cites W2137182383 @default.
- W1562111343 cites W2139629535 @default.
- W1562111343 cites W2140299202 @default.
- W1562111343 cites W2141438496 @default.
- W1562111343 cites W2144110983 @default.
- W1562111343 cites W2144377119 @default.
- W1562111343 cites W2145211974 @default.
- W1562111343 cites W2146980664 @default.
- W1562111343 cites W2147213087 @default.
- W1562111343 cites W2147405952 @default.
- W1562111343 cites W2152656580 @default.
- W1562111343 cites W2153029275 @default.
- W1562111343 cites W2153908636 @default.
- W1562111343 cites W2159492446 @default.
- W1562111343 cites W2160951409 @default.
- W1562111343 cites W2168711144 @default.
- W1562111343 cites W2170280745 @default.
- W1562111343 cites W2171993659 @default.
- W1562111343 cites W2268626592 @default.
- W1562111343 cites W2326284878 @default.
- W1562111343 cites W4250644978 @default.
- W1562111343 doi "https://doi.org/10.1111/ggi.12124" @default.
- W1562111343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23992133" @default.
- W1562111343 hasPublicationYear "2013" @default.
- W1562111343 type Work @default.
- W1562111343 sameAs 1562111343 @default.
- W1562111343 citedByCount "16" @default.
- W1562111343 countsByYear W15621113432014 @default.