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- W1562151504 abstract "The worldwide yearly mortality from sepsis is substantial, greater than that of cancer of the lung and breast combined. Moreover, its incidence is increasing, and its response to therapy has not appreciably improved. In this condition, the secretion of procalcitonin (ProCT), the prohormone of calcitonin, is augmented greatly, attaining levels up to thousands of fold of normal. This hypersecretion emanates from multiple tissues throughout the body that are not traditionally viewed as being endocrine. The serum values of ProCT correlate with the severity of sepsis; they recede with its improvement and worsen with exacerbation. Accordingly, as highlighted in this review, serum ProCT has become useful as a biomarker to assist in the diagnosis of sepsis, as well as related infectious or inflammatory conditions. It is also a useful monitor of the clinical course and prognosis, and sensitive and specific assays have been developed for its measurement. Moreover, it has been demonstrated that the administration of ProCT to septic animals greatly increases mortality, and several toxic effects of ProCT have been elucidated by in vitro experimental studies. Antibodies have been developed that neutralize the harmful effects of ProCT, and their use markedly decreases the symptomatology and mortality of animals that harbour a highly virulent sepsis analogous to that occurring in humans. This therapy is facilitated by the long duration of serum ProCT elevation, which allows for a broad window of therapeutic opportunity. An experimental groundwork has been established that suggests a potential applicability of such therapy in septic humans." @default.
- W1562151504 created "2016-06-24" @default.
- W1562151504 creator A5000383531 @default.
- W1562151504 creator A5067342885 @default.
- W1562151504 creator A5077045002 @default.
- W1562151504 date "2010-01-01" @default.
- W1562151504 modified "2023-10-17" @default.
- W1562151504 title "Procalcitonin in sepsis and systemic inflammation: a harmful biomarker and a therapeutic target" @default.
- W1562151504 cites W1888492503 @default.
- W1562151504 cites W1967320259 @default.
- W1562151504 cites W1969534289 @default.
- W1562151504 cites W1970155783 @default.
- W1562151504 cites W1970420092 @default.
- W1562151504 cites W1971277556 @default.
- W1562151504 cites W1971571453 @default.
- W1562151504 cites W1973398277 @default.
- W1562151504 cites W1974061101 @default.
- W1562151504 cites W1975477886 @default.
- W1562151504 cites W1977241402 @default.
- W1562151504 cites W1977585548 @default.
- W1562151504 cites W1978713113 @default.
- W1562151504 cites W1979278452 @default.
- W1562151504 cites W1979624395 @default.
- W1562151504 cites W1982337499 @default.
- W1562151504 cites W1983362446 @default.
- W1562151504 cites W1983575739 @default.
- W1562151504 cites W1983803867 @default.
- W1562151504 cites W1984225816 @default.
- W1562151504 cites W1988857607 @default.
- W1562151504 cites W1993137713 @default.
- W1562151504 cites W1994429311 @default.
- W1562151504 cites W1996147623 @default.
- W1562151504 cites W1999817133 @default.
- W1562151504 cites W2000282637 @default.
- W1562151504 cites W2004125965 @default.
- W1562151504 cites W2004556024 @default.
- W1562151504 cites W2006361205 @default.
- W1562151504 cites W2006524313 @default.
- W1562151504 cites W2008816582 @default.
- W1562151504 cites W2011569172 @default.
- W1562151504 cites W2012996391 @default.
- W1562151504 cites W2015345955 @default.
- W1562151504 cites W2019294202 @default.
- W1562151504 cites W2020007861 @default.
- W1562151504 cites W2020519790 @default.
- W1562151504 cites W2025487243 @default.
- W1562151504 cites W2027065937 @default.
- W1562151504 cites W2032468128 @default.
- W1562151504 cites W2034033183 @default.
- W1562151504 cites W2034291900 @default.
- W1562151504 cites W2035796687 @default.
- W1562151504 cites W2038441442 @default.
- W1562151504 cites W2039741290 @default.
- W1562151504 cites W2040068581 @default.
- W1562151504 cites W2044142824 @default.
- W1562151504 cites W2044390086 @default.
- W1562151504 cites W2045181383 @default.
- W1562151504 cites W2047914173 @default.
- W1562151504 cites W2048386999 @default.
- W1562151504 cites W2049927822 @default.
- W1562151504 cites W2050604996 @default.
- W1562151504 cites W2051101275 @default.
- W1562151504 cites W2052809746 @default.
- W1562151504 cites W2056562731 @default.
- W1562151504 cites W2059153520 @default.
- W1562151504 cites W2059460207 @default.
- W1562151504 cites W2062846875 @default.
- W1562151504 cites W2064611289 @default.
- W1562151504 cites W2067017082 @default.
- W1562151504 cites W2068338174 @default.
- W1562151504 cites W2069304036 @default.
- W1562151504 cites W2069723058 @default.
- W1562151504 cites W2070197034 @default.
- W1562151504 cites W2072160731 @default.
- W1562151504 cites W2073456616 @default.
- W1562151504 cites W2074421254 @default.
- W1562151504 cites W2077241251 @default.
- W1562151504 cites W2080954901 @default.
- W1562151504 cites W2081140318 @default.
- W1562151504 cites W2082338605 @default.
- W1562151504 cites W2082370888 @default.
- W1562151504 cites W2085911628 @default.
- W1562151504 cites W2087203965 @default.
- W1562151504 cites W2087723235 @default.
- W1562151504 cites W2088875727 @default.
- W1562151504 cites W2090413241 @default.
- W1562151504 cites W2092993771 @default.
- W1562151504 cites W2093102386 @default.
- W1562151504 cites W2093578125 @default.
- W1562151504 cites W2093695664 @default.
- W1562151504 cites W2095248510 @default.
- W1562151504 cites W2095249660 @default.
- W1562151504 cites W2095533473 @default.
- W1562151504 cites W2105249258 @default.
- W1562151504 cites W2109928541 @default.
- W1562151504 cites W2111112233 @default.
- W1562151504 cites W2113324161 @default.
- W1562151504 cites W2114957102 @default.