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• W1562409894 abstract "Andrographis paniculata, (Burm. f.) Wall. ex Nees, a herbaceous plant belonging to the Family Acanthaceae, is one of the most commonly used medicinal plants in the traditional systems of Unani and Ayurvedic medicines. It grows in hedge rows throughout the plains of India and is also cultivated in gardens. It also grows in many other Asian countries and is used as a tradition‐ al herbal medicine in China, Hong Kong, the Philippines, Malaysia, Indonesia, and Thailand. It is an annual plant of 1-3 ft high, also known as the “king of bitters”, being the aerial parts most commonly used. A. paniculata have shown a broad range of pharmacological effects such as in‐ hibition of replication of the HIV virus, prevention of common cold, and antimalarial, antidiar‐ rheal, antibacterial, antihyperglycemic effects, suppression of various cancer cells, and principally anti-inflammatory properties. Andrographolide is the major labdane diterpenoid isolated from A. paniculata and exhibits anti-inflammatory and anticancer activities, either in vi‐ tro or in vivo experimental models of inflammation and cancer. Several immunomodulatory re‐ sponses of andrographolide have been observed in in vitro studies, such as reduction of iNOS, COX-2, NO, PGE2, TNF-alpha and IL-12 in macrophages and microglia. In neutrophils is able to reduce the radical oxygen species production, and Mac-1, IL-8 and COX-2 expression. In T cells, andrographolide inhibits the expression of IL-2, IFNγ and IL-6, reducing the humoral and cellu‐ lar adaptive immune response. Andrographolide was able to reduce the dendritic cells matura‐ tion and their ability to present antigens to T cells. Andrographolide administered in rodents reduced the Th2 cytokine IL-4, IL-5, IL-13 and serum immunoglobulin in an ovalbumin in‐ duced asthma model. A reduction of T cells response also has been observed in experimental au‐ toimmune encephalomyelitis and systemic lupus erythematosus mouse model. Several of immunomodulatory responses have been associated to the inhibition of Nuclear Factor-κB" @default.
• W1562409894 created "2016-06-24" @default.
• W1562409894 creator A5024385509 @default.
• W1562409894 creator A5049268086 @default.
• W1562409894 creator A5057143697 @default.
• W1562409894 creator A5072714270 @default.
• W1562409894 date "2013-01-02" @default.
• W1562409894 modified "2023-09-25" @default.
• W1562409894 title "Andrographolide a New Potential Drug for the Long Term Treatment of Rheumatoid Arthritis Disease" @default.
• W1562409894 cites W106626313 @default.
• W1562409894 cites W106859092 @default.
• W1562409894 cites W126217288 @default.
• W1562409894 cites W1491294744 @default.
• W1562409894 cites W1494713318 @default.
• W1562409894 cites W1499946374 @default.
• W1562409894 cites W1528662449 @default.
• W1562409894 cites W1723251513 @default.
• W1562409894 cites W1970588308 @default.
• W1562409894 cites W1972892830 @default.
• W1562409894 cites W1972901014 @default.
• W1562409894 cites W1975871282 @default.
• W1562409894 cites W1977291272 @default.
• W1562409894 cites W1980749791 @default.
• W1562409894 cites W1986222727 @default.
• W1562409894 cites W1986549410 @default.
• W1562409894 cites W1987147444 @default.
• W1562409894 cites W1989694559 @default.
• W1562409894 cites W1989777330 @default.
• W1562409894 cites W1990092707 @default.
• W1562409894 cites W1997359763 @default.
• W1562409894 cites W1997835235 @default.
• W1562409894 cites W1998885858 @default.
• W1562409894 cites W2001064696 @default.
• W1562409894 cites W2003651414 @default.
• W1562409894 cites W2003704382 @default.
• W1562409894 cites W2003747141 @default.
• W1562409894 cites W2005193397 @default.
• W1562409894 cites W2008190269 @default.
• W1562409894 cites W2012804923 @default.
• W1562409894 cites W2016648276 @default.
• W1562409894 cites W2017412008 @default.
• W1562409894 cites W2017516341 @default.
• W1562409894 cites W2019162634 @default.
• W1562409894 cites W2023659954 @default.
• W1562409894 cites W2024211026 @default.
• W1562409894 cites W2026543066 @default.
• W1562409894 cites W2027139637 @default.
• W1562409894 cites W2032611317 @default.
• W1562409894 cites W2034076768 @default.
• W1562409894 cites W2034672510 @default.
• W1562409894 cites W2039137878 @default.
• W1562409894 cites W2040948154 @default.
• W1562409894 cites W2041224389 @default.
• W1562409894 cites W2042059400 @default.
• W1562409894 cites W2044258256 @default.
• W1562409894 cites W2051909517 @default.
• W1562409894 cites W2053695710 @default.
• W1562409894 cites W2056686776 @default.
• W1562409894 cites W2057575288 @default.
• W1562409894 cites W2059565612 @default.
• W1562409894 cites W2062073020 @default.
• W1562409894 cites W2064623085 @default.
• W1562409894 cites W2065326632 @default.
• W1562409894 cites W2068084252 @default.
• W1562409894 cites W2069378615 @default.
• W1562409894 cites W2070446195 @default.
• W1562409894 cites W2073027199 @default.
• W1562409894 cites W2073472995 @default.
• W1562409894 cites W2076841532 @default.
• W1562409894 cites W2077672218 @default.
• W1562409894 cites W2081225089 @default.
• W1562409894 cites W2088455943 @default.
• W1562409894 cites W2094650613 @default.
• W1562409894 cites W2097188560 @default.
• W1562409894 cites W2102498134 @default.
• W1562409894 cites W2105391814 @default.
• W1562409894 cites W2109426473 @default.
• W1562409894 cites W2111026040 @default.
• W1562409894 cites W2112103893 @default.
• W1562409894 cites W2117382612 @default.
• W1562409894 cites W2122044177 @default.
• W1562409894 cites W2133103918 @default.
• W1562409894 cites W2134606453 @default.
• W1562409894 cites W2137278400 @default.
• W1562409894 cites W2144556114 @default.
• W1562409894 cites W2149724396 @default.
• W1562409894 cites W2149781411 @default.
• W1562409894 cites W2151701444 @default.
• W1562409894 cites W2153550994 @default.
• W1562409894 cites W2161957478 @default.
• W1562409894 cites W2185650251 @default.
• W1562409894 cites W2325111718 @default.
• W1562409894 cites W2335288513 @default.
• W1562409894 cites W2418383125 @default.
• W1562409894 cites W2481759650 @default.
• W1562409894 cites W2839362975 @default.
• W1562409894 cites W51515446 @default.
• W1562409894 cites W67411145 @default.
• W1562409894 doi "https://doi.org/10.5772/55642" @default.
• W1562409894 hasPublicationYear "2013" @default.

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