FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1562637996> ?p ?o ?g. }

• W1562637996 endingPage "366" @default.
• W1562637996 startingPage "357" @default.
• W1562637996 abstract "Publisher Summary In the United States, protein crystallography was started in 1950, with the formation of the protein structure project (PSP) under the leadership of David Harker. At the beginning of the research, Harker and his men faced overwhelming problems including some technical obstructions also. By mid-fifties, it had become clear that the study of shrinkage stages of protein crystals was not going to lead to a structure. In principle, three isomorphous crystals are a necessary and sufficient condition to determine all the phases of a noncentrosymmetrical protein crystal. The derivation and mathematics of the multiple isomorphous replacement method was first described completely by Harker in a classic paper appearing as the first article of the first issue of Acta crystullographica in 1956. All that remained was to prepare several suitable heavy atom isomorphous derivatives of ribonuclease crystals to solve the protein phase angles and compute an electron density map that would reveal the structure at the atomic level. An unexpected by-product of the work was the very early observation of bonding electrons and the general acceptance of beryllium acetate crystals as an intensity standard. Many potential heavy atom derivatives were measured and analyzed with high hopes over a 2-3 year period only to spawn discouragement. But very soon, the 2.0Ǻ resolution map and structure of myoglobin was published. The effort received a significant boost in 1963 and the structure was solved at 2.0Ǻ resolution. It can be said safely that the tremendous progress and growth of protein crystallography worldwide over the last 30-40 years is probably stunning even to those with whom it originated. However, interactive computer graphics might well be the most crucial and important development of protein crystallography. Protein crystallography is indeed wondrous and is attracting the finest intellectual talent in the world." @default.
• W1562637996 created "2016-06-24" @default.
• W1562637996 creator A5048811360 @default.
• W1562637996 date "1996-01-01" @default.
• W1562637996 modified "2023-09-27" @default.
• W1562637996 title "Chapter 35. The Protein Structure Project, 1950–1959: First Concerted Effort of a Protein Structure Determination in the U.S." @default.
• W1562637996 cites W1964155174 @default.
• W1562637996 cites W1973677589 @default.
• W1562637996 cites W1982939197 @default.
• W1562637996 cites W1983204108 @default.
• W1562637996 cites W1985854865 @default.
• W1562637996 cites W1992406373 @default.
• W1562637996 cites W2004436328 @default.
• W1562637996 cites W2007067787 @default.
• W1562637996 cites W2015370423 @default.
• W1562637996 cites W2018505296 @default.
• W1562637996 cites W2027877999 @default.
• W1562637996 cites W2030944998 @default.
• W1562637996 cites W2032868338 @default.
• W1562637996 cites W2046449959 @default.
• W1562637996 cites W2051291983 @default.
• W1562637996 cites W2053653401 @default.
• W1562637996 cites W2067074453 @default.
• W1562637996 cites W2072618000 @default.
• W1562637996 cites W2074294128 @default.
• W1562637996 cites W2077834815 @default.
• W1562637996 cites W2084581203 @default.
• W1562637996 cites W2088522193 @default.
• W1562637996 cites W2095179527 @default.
• W1562637996 cites W2097402331 @default.
• W1562637996 cites W2111685760 @default.
• W1562637996 cites W2140992384 @default.
• W1562637996 cites W2143732296 @default.
• W1562637996 cites W2154352118 @default.
• W1562637996 cites W2156078490 @default.
• W1562637996 cites W2316913523 @default.
• W1562637996 cites W2323270782 @default.
• W1562637996 cites W2086898258 @default.
• W1562637996 doi "https://doi.org/10.1016/s0065-7743(08)60474-1" @default.
• W1562637996 hasPublicationYear "1996" @default.
• W1562637996 type Work @default.
• W1562637996 sameAs 1562637996 @default.
• W1562637996 citedByCount "1" @default.
• W1562637996 countsByYear W15626379962023 @default.
• W1562637996 crossrefType "book-chapter" @default.
• W1562637996 hasAuthorship W1562637996A5048811360 @default.
• W1562637996 hasConcept C185592680 @default.
• W1562637996 hasConcept C47701112 @default.
• W1562637996 hasConcept C55493867 @default.
• W1562637996 hasConcept C70721500 @default.
• W1562637996 hasConcept C86803240 @default.
• W1562637996 hasConceptScore W1562637996C185592680 @default.
• W1562637996 hasConceptScore W1562637996C47701112 @default.
• W1562637996 hasConceptScore W1562637996C55493867 @default.
• W1562637996 hasConceptScore W1562637996C70721500 @default.
• W1562637996 hasConceptScore W1562637996C86803240 @default.
• W1562637996 hasLocation W15626379961 @default.
• W1562637996 hasOpenAccess W1562637996 @default.
• W1562637996 hasPrimaryLocation W15626379961 @default.
• W1562637996 hasRelatedWork W1020920971 @default.
• W1562637996 hasRelatedWork W1995553782 @default.
• W1562637996 hasRelatedWork W2020481171 @default.
• W1562637996 hasRelatedWork W2081655977 @default.
• W1562637996 hasRelatedWork W2119378770 @default.
• W1562637996 hasRelatedWork W2147794249 @default.
• W1562637996 hasRelatedWork W2153819507 @default.
• W1562637996 hasRelatedWork W2747781304 @default.
• W1562637996 hasRelatedWork W2903084665 @default.
• W1562637996 hasRelatedWork W63398591 @default.
• W1562637996 isParatext "false" @default.
• W1562637996 isRetracted "false" @default.
• W1562637996 magId "1562637996" @default.
• W1562637996 workType "book-chapter" @default.