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- W1562646593 abstract "Amyloidosis is a disease characterized by the deposition of abnormal proteins in extracellular tissue. The deposits originate from serum derived or locally produced proteins. (Sipe et al., 2010) The term “amyloid” was first used by Rudolph Virchow in 1854. (Saleiro et al., 2008) According to the Nomenclature Committee of the International Society of Amyloidosis 2010 recommendations, an amyloid fibril protein must occur in tissue deposits and exhibit affinity for Congo red and green birefringence when viewed by polarization microscopy. Furthermore, the protein must have been unambiguously characterized by protein sequence analysis (DNA sequencing in the case of familial diseases). In this chapter, we will focus on the pulmonary manifestations of amyloid. We will discuss the classification, presentation, symptoms, diagnostic testing and therapeutic options with regards to amyloid in the respiratory tract. Amyloidosis had been classified over the years based on the site of deposition and presence or absence of other diseases. (Thompson & Citron, 1983) The term “Generalized” or “Systemic” had been used to describe deposition in multiple anatomic sites and “localized” used to describe deposition in one anatomic site. The term “secondary” used to describe patients with coexistent disease like multiple myeloma and “primary” for patients with no such coexistent disease. (Utz et al., 1996)" @default.
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- W1562646593 date "2011-11-16" @default.
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- W1562646593 title "Pulmonary Manifestations of Amyloidosis" @default.
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- W1562646593 doi "https://doi.org/10.5772/23776" @default.
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