Matches in SemOpenAlex for { <https://semopenalex.org/work/W1562891630> ?p ?o ?g. }
- W1562891630 endingPage "1732" @default.
- W1562891630 startingPage "1723" @default.
- W1562891630 abstract "Abstract We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses. Adiponectin suppressed colony formation from colony-forming units (CFU)—granulocyte-macrophage, CFU-macrophage, and CFU-granulocyte, whereas it had no effect on that of burst-forming units—erythroid or mixed erythroid-myeloid CFU. In addition, adiponectin inhibited proliferation of 4 of 9 myeloid cell lines but did not suppress proliferation of erythroid or lymphoid cell lines except for one cell line. These results suggest that adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells. At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. Aside from inhibiting growth of myelomonocytic progenitors, adiponectin suppressed mature macrophage functions. Treatment of cultured macrophages with adiponectin significantly inhibited their phagocytic activity and their lipopolysaccharide-induced production of tumor necrosis factor α. Suppression of phagocytosis by adiponectin is mediated by one of the complement C1q receptors, C1qRp, because this function was completely abrogated by the addition of an anti-C1qRp monoclonal antibody. These observations suggest that adiponectin is an important negative regulator in hematopoiesis and immune systems and raise the possibility that it may be involved in ending inflammatory responses through its inhibitory functions." @default.
- W1562891630 created "2016-06-24" @default.
- W1562891630 creator A5030091429 @default.
- W1562891630 creator A5033747502 @default.
- W1562891630 creator A5034468688 @default.
- W1562891630 creator A5041987541 @default.
- W1562891630 creator A5058106624 @default.
- W1562891630 creator A5066393135 @default.
- W1562891630 creator A5071748350 @default.
- W1562891630 creator A5076422953 @default.
- W1562891630 creator A5080908654 @default.
- W1562891630 creator A5081091831 @default.
- W1562891630 creator A5086129270 @default.
- W1562891630 date "2000-09-01" @default.
- W1562891630 modified "2023-10-16" @default.
- W1562891630 title "Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages" @default.
- W1562891630 cites W1606157168 @default.
- W1562891630 cites W183757317 @default.
- W1562891630 cites W1908008858 @default.
- W1562891630 cites W1977627900 @default.
- W1562891630 cites W1981261500 @default.
- W1562891630 cites W1983627019 @default.
- W1562891630 cites W1989271276 @default.
- W1562891630 cites W1996713062 @default.
- W1562891630 cites W2000464317 @default.
- W1562891630 cites W2001727439 @default.
- W1562891630 cites W2001783191 @default.
- W1562891630 cites W2004594321 @default.
- W1562891630 cites W2009488396 @default.
- W1562891630 cites W2009550948 @default.
- W1562891630 cites W2018006042 @default.
- W1562891630 cites W2025929654 @default.
- W1562891630 cites W2026745476 @default.
- W1562891630 cites W2040845651 @default.
- W1562891630 cites W2047233465 @default.
- W1562891630 cites W2047774312 @default.
- W1562891630 cites W2048234485 @default.
- W1562891630 cites W2054895339 @default.
- W1562891630 cites W2059766176 @default.
- W1562891630 cites W2062162775 @default.
- W1562891630 cites W2067190714 @default.
- W1562891630 cites W2067217824 @default.
- W1562891630 cites W2067935095 @default.
- W1562891630 cites W2068193118 @default.
- W1562891630 cites W2071450466 @default.
- W1562891630 cites W2076841009 @default.
- W1562891630 cites W2079424499 @default.
- W1562891630 cites W2090977677 @default.
- W1562891630 cites W2099826413 @default.
- W1562891630 cites W2111069558 @default.
- W1562891630 cites W2124413774 @default.
- W1562891630 cites W2146335356 @default.
- W1562891630 cites W2148890292 @default.
- W1562891630 cites W2161435735 @default.
- W1562891630 cites W2191654227 @default.
- W1562891630 cites W2218441948 @default.
- W1562891630 cites W2418060718 @default.
- W1562891630 cites W347895934 @default.
- W1562891630 cites W4234856678 @default.
- W1562891630 cites W4240710787 @default.
- W1562891630 cites W4245298382 @default.
- W1562891630 cites W4322388561 @default.
- W1562891630 cites W99541121 @default.
- W1562891630 doi "https://doi.org/10.1182/blood.v96.5.1723" @default.
- W1562891630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10961870" @default.
- W1562891630 hasPublicationYear "2000" @default.
- W1562891630 type Work @default.
- W1562891630 sameAs 1562891630 @default.
- W1562891630 citedByCount "1351" @default.
- W1562891630 countsByYear W15628916302012 @default.
- W1562891630 countsByYear W15628916302013 @default.
- W1562891630 countsByYear W15628916302014 @default.
- W1562891630 countsByYear W15628916302015 @default.
- W1562891630 countsByYear W15628916302016 @default.
- W1562891630 countsByYear W15628916302017 @default.
- W1562891630 countsByYear W15628916302018 @default.
- W1562891630 countsByYear W15628916302019 @default.
- W1562891630 countsByYear W15628916302020 @default.
- W1562891630 countsByYear W15628916302021 @default.
- W1562891630 countsByYear W15628916302022 @default.
- W1562891630 countsByYear W15628916302023 @default.
- W1562891630 crossrefType "journal-article" @default.
- W1562891630 hasAuthorship W1562891630A5030091429 @default.
- W1562891630 hasAuthorship W1562891630A5033747502 @default.
- W1562891630 hasAuthorship W1562891630A5034468688 @default.
- W1562891630 hasAuthorship W1562891630A5041987541 @default.
- W1562891630 hasAuthorship W1562891630A5058106624 @default.
- W1562891630 hasAuthorship W1562891630A5066393135 @default.
- W1562891630 hasAuthorship W1562891630A5071748350 @default.
- W1562891630 hasAuthorship W1562891630A5076422953 @default.
- W1562891630 hasAuthorship W1562891630A5080908654 @default.
- W1562891630 hasAuthorship W1562891630A5081091831 @default.
- W1562891630 hasAuthorship W1562891630A5086129270 @default.
- W1562891630 hasConcept C109159458 @default.
- W1562891630 hasConcept C126322002 @default.
- W1562891630 hasConcept C134018914 @default.
- W1562891630 hasConcept C160448771 @default.
- W1562891630 hasConcept C201750760 @default.