Matches in SemOpenAlex for { <https://semopenalex.org/work/W1562982017> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1562982017 endingPage "609" @default.
- W1562982017 startingPage "602" @default.
- W1562982017 abstract "1. By means of a gas-liquid chromatographic technique the effect of exogenous cholesterol on the incorporation of acetate-2-14C into β-hydroxy-β-methylglutarate and mevalonate has been measured both in cell-free systems of liver and in intact liver cells. 2. It has been shown that mevalonate synthesis is markedly suppressed by cholesterol feeding while the synthesis of β-hydroxy-β-methylglutarate is unaffected by this regimen. These results are consistent with the conclusion that the major site of the cholesterol feedback system is located at the reaction responsible for the conversion of β-hydroxy-β-methylglutarate to mevalonate; namely β-hydroxy-β-methylglutaryl reductase. 3. The intracellular localization of mevalonate synthesis and its feedback control have been likewise examined. Mevalonate was found to be synthesized in both microsomal and soluble fractions of the liver cell; however, the major site of mevalonate synthesis, and hence of feedback control of cholesterol synthesis, is localized to the membranous fraction of the microsomes." @default.
- W1562982017 created "2016-06-24" @default.
- W1562982017 creator A5053963822 @default.
- W1562982017 creator A5076308381 @default.
- W1562982017 date "1966-02-01" @default.
- W1562982017 modified "2023-10-14" @default.
- W1562982017 title "Feedback Control of Mevalonate Synthesis by Dietary Cholesterol" @default.
- W1562982017 cites W104696514 @default.
- W1562982017 cites W123997397 @default.
- W1562982017 cites W149329135 @default.
- W1562982017 cites W1500243384 @default.
- W1562982017 cites W1503880894 @default.
- W1562982017 cites W1526010060 @default.
- W1562982017 cites W1531999000 @default.
- W1562982017 cites W1558765348 @default.
- W1562982017 cites W174202133 @default.
- W1562982017 cites W1978031737 @default.
- W1562982017 cites W2005778380 @default.
- W1562982017 cites W2006180488 @default.
- W1562982017 cites W2023344829 @default.
- W1562982017 cites W2044564000 @default.
- W1562982017 cites W2064285881 @default.
- W1562982017 cites W2065479434 @default.
- W1562982017 cites W2074438675 @default.
- W1562982017 cites W2078307397 @default.
- W1562982017 cites W2117702558 @default.
- W1562982017 cites W2121563980 @default.
- W1562982017 cites W2125483042 @default.
- W1562982017 cites W2186099052 @default.
- W1562982017 cites W2274863277 @default.
- W1562982017 cites W2412381691 @default.
- W1562982017 cites W2417606159 @default.
- W1562982017 cites W30266437 @default.
- W1562982017 cites W4241568373 @default.
- W1562982017 cites W51791299 @default.
- W1562982017 cites W64576928 @default.
- W1562982017 cites W80538366 @default.
- W1562982017 doi "https://doi.org/10.1016/s0021-9258(18)96879-1" @default.
- W1562982017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5908125" @default.
- W1562982017 hasPublicationYear "1966" @default.
- W1562982017 type Work @default.
- W1562982017 sameAs 1562982017 @default.
- W1562982017 citedByCount "305" @default.
- W1562982017 countsByYear W15629820172012 @default.
- W1562982017 countsByYear W15629820172013 @default.
- W1562982017 countsByYear W15629820172014 @default.
- W1562982017 countsByYear W15629820172015 @default.
- W1562982017 countsByYear W15629820172016 @default.
- W1562982017 countsByYear W15629820172017 @default.
- W1562982017 countsByYear W15629820172018 @default.
- W1562982017 countsByYear W15629820172019 @default.
- W1562982017 countsByYear W15629820172021 @default.
- W1562982017 countsByYear W15629820172022 @default.
- W1562982017 countsByYear W15629820172023 @default.
- W1562982017 crossrefType "journal-article" @default.
- W1562982017 hasAuthorship W1562982017A5053963822 @default.
- W1562982017 hasAuthorship W1562982017A5076308381 @default.
- W1562982017 hasBestOaLocation W15629820171 @default.
- W1562982017 hasConcept C134651460 @default.
- W1562982017 hasConcept C154945302 @default.
- W1562982017 hasConcept C181199279 @default.
- W1562982017 hasConcept C185592680 @default.
- W1562982017 hasConcept C2775924081 @default.
- W1562982017 hasConcept C2778163477 @default.
- W1562982017 hasConcept C3017755632 @default.
- W1562982017 hasConcept C41008148 @default.
- W1562982017 hasConcept C55493867 @default.
- W1562982017 hasConceptScore W1562982017C134651460 @default.
- W1562982017 hasConceptScore W1562982017C154945302 @default.
- W1562982017 hasConceptScore W1562982017C181199279 @default.
- W1562982017 hasConceptScore W1562982017C185592680 @default.
- W1562982017 hasConceptScore W1562982017C2775924081 @default.
- W1562982017 hasConceptScore W1562982017C2778163477 @default.
- W1562982017 hasConceptScore W1562982017C3017755632 @default.
- W1562982017 hasConceptScore W1562982017C41008148 @default.
- W1562982017 hasConceptScore W1562982017C55493867 @default.
- W1562982017 hasIssue "3" @default.
- W1562982017 hasLocation W15629820171 @default.
- W1562982017 hasOpenAccess W1562982017 @default.
- W1562982017 hasPrimaryLocation W15629820171 @default.
- W1562982017 hasRelatedWork W1780108031 @default.
- W1562982017 hasRelatedWork W1990049915 @default.
- W1562982017 hasRelatedWork W1996118476 @default.
- W1562982017 hasRelatedWork W2009125299 @default.
- W1562982017 hasRelatedWork W2073922617 @default.
- W1562982017 hasRelatedWork W2081195001 @default.
- W1562982017 hasRelatedWork W2081216365 @default.
- W1562982017 hasRelatedWork W2106077617 @default.
- W1562982017 hasRelatedWork W2130057972 @default.
- W1562982017 hasRelatedWork W2922141675 @default.
- W1562982017 hasVolume "241" @default.
- W1562982017 isParatext "false" @default.
- W1562982017 isRetracted "false" @default.
- W1562982017 magId "1562982017" @default.
- W1562982017 workType "article" @default.