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• W1563076404 endingPage "1826" @default.
• W1563076404 startingPage "1820" @default.
• W1563076404 abstract "Type I IFN (IFN-I or IFN-alphabeta) plays an important role in the innate immune response against viral infection. Here we report that a potent inducer of IFN-alphabeta, polyinosinic-polycytidylic acid [poly(I:C)], led to the depletion of T cells in young, but not aged mice, and that this depletion was limited to central memory, but not effector memory, T cells. Although early activation of T cells in vivo by poly(I:C), as demonstrated by CD69, was not impaired with aging, the expression of active caspase-3 was higher in young compared with aged mice. This depletion of T cells and induction of active caspase-3 in young mice and of CD69 in both young and aged mice by poly(I:C) were blocked by anti-IFN-alphabeta Ab. Although poly(I:C) stimulated lower circulating levels of IFN-alphabeta in aged mice, administration of IFN-alphabeta after poly(I:C) did not induce depletion of T cells in aged mice. These results indicate that IFN-alphabeta plays a critical role in the depletion of T cells of young mice, and further suggest that the lower level of functional IFN-alphabeta and decreased induction of active caspase-3 in T cells of aged mice after poly(I:C) may be responsible for the increased resistance of T cells of aged mice to depletion." @default.
• W1563076404 created "2016-06-24" @default.
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• W1563076404 date "2005-08-01" @default.
• W1563076404 modified "2023-10-17" @default.
• W1563076404 title "Depletion of T Cells by Type I Interferon: Differences between Young and Aged Mice" @default.
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• W1563076404 doi "https://doi.org/10.4049/jimmunol.175.3.1820" @default.
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