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- W1563085745 abstract "1.1 Epidemiology and basic characteristics Endogenous hyperinsulinism is characterized by repeated hypoglycemic episodes caused by autonomous hypersecretion of insulin produced by adenoma or multiple microadenomatosis originating in the beta-cells of the pancreas. The process is either localized into one or less frequently few solid tumors or is more diffuse within the islets of Langerhans. Endogenous hyperinsulinism is not regulated by plasma glucose and therefore clinical signs of hypoglycemia manifest whenever during the day. The term „organic hyperinsulinism“ is sometimes used showing that real endocrine pancreatic disease may be present in comparison with „functional hyperinsulinism“ characterized by reactive changes in a consequence of eating habits. Insulinoma (ICD-08151/1, ICD-08151/3) together with gastrinoma, VIPoma, somatostatinoma, glucagonoma and PPoma are members of nesidioma family which are recognized as neuroendocrine tumors of the pancreas. Some of them produce one hormone only and may therefore cause typical clinical symptoms. However, combined production of hormones may be also found and clinical diagnosis could be difficult when different symptoms would be combined. Positive but weak staining for gastrin or other hormones besides insulin may be sometimes present without any symptoms. On the other hand, neuroendocrine tumor in the pancreas can be described by histological examination in patients without typical clinical symptoms and malignant tumors are then confirmed. Insulinoma has incidence of 0.05-0.1 cases per 100 000 inhabitants in the Czech Republic (Skrha, 2001) but slightly more (0.4 per 100 000) has been described at the Mayo clinic register (Service et al., 1991). Data may depend on the database availability in different countries. It is predominantly present in women as compared to men. The proportion of insulinoma was around 60 % in women at Mayo clinic whereas our register involves 75 % of women (Service et al., 1991, Skrha et al., 2009). Insulin-producing tumors occur in more than 50 % of neuroendocrine tumors of the pancreas followed by gastrinomas in 30 %, VIPomas in 10-15 % and by others in less than 10 % (Perry & Vinik, 1995)." @default.
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- W1563085745 date "2011-10-10" @default.
- W1563085745 modified "2023-10-01" @default.
- W1563085745 title "Insulinoma – Diagnosis and Treatment" @default.
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- W1563085745 doi "https://doi.org/10.5772/20583" @default.
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