FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1563409476> ?p ?o ?g. }

• W1563409476 endingPage "48" @default.
• W1563409476 startingPage "239" @default.
• W1563409476 abstract "MK615 is produced from Japanese apricot and contains several cyclic triterpenes, such as oleanolic and ursolic acids. MK615 was shown to strongly suppress cutaneous in-transit metastasis in a patient with malignant melanoma. The present investigation was undertaken to clarify the antitumor effects of MK615 in vitro and in vivo.Several human cancer cell lines were exposed to MK615 for 7 days to examine its antiproliferative effects. The effect of MK615 on in vivo growth of human pancreatic cancer MIAPaCa-2 cells was also examined.MK615 inhibited the growth of several human cancer cell lines in a concentration-dependent way. Pancreatic cancer MIAPaCa-2 cells were highly sensitive to the growth-inhibiting effects of MK615. Treatment with MK615 preferentially induced cell death in human cancer cells while sparing normal cells such as human umbilical vein endothelial cells (HUVEC) and mouse bone marrow cells. When MIAPaCa-2 cells were incubated with MK615 in the presence of antioxidant, growth-inhibition was significantly reduced, and MK615 induced the accumulation of reactive oxygen species in cancer cells but not in HUVEC. MK615, in both the presence and absence of gemcitabine, significantly inhibited the growth of human pancreatic cancer cells as xenografts without apparent adverse effects.MK615, a supplement produced from Japanese apricot, may have therapeutic value in treating human cancers through a reactive oxygen species-dependent mechanism." @default.
• W1563409476 created "2016-06-24" @default.
• W1563409476 creator A5041181447 @default.
• W1563409476 creator A5043036395 @default.
• W1563409476 creator A5046638834 @default.
• W1563409476 creator A5046840239 @default.
• W1563409476 creator A5063681703 @default.
• W1563409476 creator A5075245514 @default.
• W1563409476 date "2013-06-12" @default.
• W1563409476 modified "2023-09-23" @default.
• W1563409476 title "Antitumor effect of Japanese apricot extract (MK615) on human cancer cells in vitro and in vivo through a reactive oxygen species-dependent mechanism." @default.
• W1563409476 cites W1809723326 @default.
• W1563409476 cites W1900906251 @default.
• W1563409476 cites W1965009601 @default.
• W1563409476 cites W1968607017 @default.
• W1563409476 cites W1980447537 @default.
• W1563409476 cites W1993238109 @default.
• W1563409476 cites W1994508517 @default.
• W1563409476 cites W1998769605 @default.
• W1563409476 cites W2010023860 @default.
• W1563409476 cites W2010090075 @default.
• W1563409476 cites W2011006339 @default.
• W1563409476 cites W2012274352 @default.
• W1563409476 cites W2028486025 @default.
• W1563409476 cites W2050030744 @default.
• W1563409476 cites W2055478604 @default.
• W1563409476 cites W2063953032 @default.
• W1563409476 cites W2069126054 @default.
• W1563409476 cites W2072569792 @default.
• W1563409476 cites W2077945404 @default.
• W1563409476 cites W2080315869 @default.
• W1563409476 cites W2088855891 @default.
• W1563409476 cites W2095170070 @default.
• W1563409476 cites W2099828790 @default.
• W1563409476 cites W2109238300 @default.
• W1563409476 cites W2109637975 @default.
• W1563409476 cites W2114955277 @default.
• W1563409476 cites W2121385987 @default.
• W1563409476 cites W2129111567 @default.
• W1563409476 cites W2129778797 @default.
• W1563409476 cites W2135642745 @default.
• W1563409476 doi "https://doi.org/10.1700/1283.14199" @default.
• W1563409476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23748821" @default.
• W1563409476 hasPublicationYear "2013" @default.
• W1563409476 type Work @default.
• W1563409476 sameAs 1563409476 @default.
• W1563409476 citedByCount "4" @default.
• W1563409476 countsByYear W15634094762014 @default.
• W1563409476 countsByYear W15634094762017 @default.
• W1563409476 crossrefType "journal-article" @default.
• W1563409476 hasAuthorship W1563409476A5041181447 @default.
• W1563409476 hasAuthorship W1563409476A5043036395 @default.
• W1563409476 hasAuthorship W1563409476A5046638834 @default.
• W1563409476 hasAuthorship W1563409476A5046840239 @default.
• W1563409476 hasAuthorship W1563409476A5063681703 @default.
• W1563409476 hasAuthorship W1563409476A5075245514 @default.
• W1563409476 hasConcept C121608353 @default.
• W1563409476 hasConcept C126322002 @default.
• W1563409476 hasConcept C150903083 @default.
• W1563409476 hasConcept C185592680 @default.
• W1563409476 hasConcept C202751555 @default.
• W1563409476 hasConcept C207001950 @default.
• W1563409476 hasConcept C2777411675 @default.
• W1563409476 hasConcept C2780210213 @default.
• W1563409476 hasConcept C48349386 @default.
• W1563409476 hasConcept C502942594 @default.
• W1563409476 hasConcept C54355233 @default.
• W1563409476 hasConcept C55493867 @default.
• W1563409476 hasConcept C62112901 @default.
• W1563409476 hasConcept C71924100 @default.
• W1563409476 hasConcept C81885089 @default.
• W1563409476 hasConcept C86803240 @default.
• W1563409476 hasConcept C96232424 @default.
• W1563409476 hasConcept C98274493 @default.
• W1563409476 hasConceptScore W1563409476C121608353 @default.
• W1563409476 hasConceptScore W1563409476C126322002 @default.
• W1563409476 hasConceptScore W1563409476C150903083 @default.
• W1563409476 hasConceptScore W1563409476C185592680 @default.
• W1563409476 hasConceptScore W1563409476C202751555 @default.
• W1563409476 hasConceptScore W1563409476C207001950 @default.
• W1563409476 hasConceptScore W1563409476C2777411675 @default.
• W1563409476 hasConceptScore W1563409476C2780210213 @default.
• W1563409476 hasConceptScore W1563409476C48349386 @default.
• W1563409476 hasConceptScore W1563409476C502942594 @default.
• W1563409476 hasConceptScore W1563409476C54355233 @default.
• W1563409476 hasConceptScore W1563409476C55493867 @default.
• W1563409476 hasConceptScore W1563409476C62112901 @default.
• W1563409476 hasConceptScore W1563409476C71924100 @default.
• W1563409476 hasConceptScore W1563409476C81885089 @default.
• W1563409476 hasConceptScore W1563409476C86803240 @default.
• W1563409476 hasConceptScore W1563409476C96232424 @default.
• W1563409476 hasConceptScore W1563409476C98274493 @default.
• W1563409476 hasIssue "2" @default.
• W1563409476 hasLocation W15634094761 @default.
• W1563409476 hasOpenAccess W1563409476 @default.
• W1563409476 hasPrimaryLocation W15634094761 @default.
• W1563409476 hasRelatedWork W1983855168 @default.
• W1563409476 hasRelatedWork W2020692772 @default.

• next