FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1563454002> ?p ?o ?g. }

• W1563454002 endingPage "12957" @default.
• W1563454002 startingPage "12943" @default.
• W1563454002 abstract "RNA-dependent RNA polymerases (RdRPs) from the Flaviviridae family are representatives of viral polymerases that carry out RNA synthesis through a de novo initiation mechanism. They share a ≈ 600-residue polymerase core that displays a canonical viral RdRP architecture resembling an encircled right hand with palm, fingers, and thumb domains surrounding the active site. Polymerase catalytic motifs A-E in the palm and motifs F/G in the fingers are shared by all viral RdRPs with sequence and/or structural conservations regardless of the mechanism of initiation. Different from RdRPs carrying out primer-dependent initiation, Flaviviridae and other de novo RdRPs utilize a priming element often integrated in the thumb domain to facilitate primer-independent initiation. Upon the transition to the elongation phase, this priming element needs to undergo currently unresolved conformational rearrangements to accommodate the growth of the template-product RNA duplex. In the genera of Flavivirus and Pestivirus, the polymerase module in the C-terminal part of the RdRP protein may be regulated in cis by the N-terminal region of the same polypeptide. Either being a methyltransferase in Flavivirus or a functionally unclarified module in Pestivirus, this region could play auxiliary roles for the canonical folding and/or the catalysis of the polymerase, through defined intra-molecular interactions." @default.
• W1563454002 created "2016-06-24" @default.
• W1563454002 creator A5049012342 @default.
• W1563454002 creator A5062257507 @default.
• W1563454002 creator A5090972511 @default.
• W1563454002 date "2015-06-08" @default.
• W1563454002 modified "2023-10-01" @default.
• W1563454002 title "A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family" @default.
• W1563454002 cites W1519899019 @default.
• W1563454002 cites W1571552114 @default.
• W1563454002 cites W1582561043 @default.
• W1563454002 cites W1619579175 @default.
• W1563454002 cites W1914838920 @default.
• W1563454002 cites W1932632320 @default.
• W1563454002 cites W1967154222 @default.
• W1563454002 cites W1971792395 @default.
• W1563454002 cites W1972132067 @default.
• W1563454002 cites W1973711348 @default.
• W1563454002 cites W1973792861 @default.
• W1563454002 cites W1982898421 @default.
• W1563454002 cites W1983291263 @default.
• W1563454002 cites W1984349537 @default.
• W1563454002 cites W1988411933 @default.
• W1563454002 cites W1992048113 @default.
• W1563454002 cites W1992378816 @default.
• W1563454002 cites W1994737397 @default.
• W1563454002 cites W2000594526 @default.
• W1563454002 cites W2011579843 @default.
• W1563454002 cites W2031392474 @default.
• W1563454002 cites W2033345469 @default.
• W1563454002 cites W2037981763 @default.
• W1563454002 cites W2040837844 @default.
• W1563454002 cites W2045578601 @default.
• W1563454002 cites W2052351457 @default.
• W1563454002 cites W2053012994 @default.
• W1563454002 cites W2053792903 @default.
• W1563454002 cites W2054896136 @default.
• W1563454002 cites W2066737143 @default.
• W1563454002 cites W2067108917 @default.
• W1563454002 cites W2067989594 @default.
• W1563454002 cites W2072603184 @default.
• W1563454002 cites W2074817393 @default.
• W1563454002 cites W2075583438 @default.
• W1563454002 cites W2083901349 @default.
• W1563454002 cites W2085323444 @default.
• W1563454002 cites W2087818806 @default.
• W1563454002 cites W2089945673 @default.
• W1563454002 cites W2091795018 @default.
• W1563454002 cites W2092052419 @default.
• W1563454002 cites W2101643828 @default.
• W1563454002 cites W2102686303 @default.
• W1563454002 cites W2103660789 @default.
• W1563454002 cites W2110670926 @default.
• W1563454002 cites W2111302701 @default.
• W1563454002 cites W2119473061 @default.
• W1563454002 cites W2126826536 @default.
• W1563454002 cites W2128535933 @default.
• W1563454002 cites W2131139392 @default.
• W1563454002 cites W2137357029 @default.
• W1563454002 cites W2140518449 @default.
• W1563454002 cites W2141342171 @default.
• W1563454002 cites W2144488951 @default.
• W1563454002 cites W2149410625 @default.
• W1563454002 cites W2154666681 @default.
• W1563454002 cites W2154746801 @default.
• W1563454002 cites W2157839983 @default.
• W1563454002 cites W2158502531 @default.
• W1563454002 cites W2162799182 @default.
• W1563454002 cites W2163412375 @default.
• W1563454002 cites W2163972968 @default.
• W1563454002 cites W2165969670 @default.
• W1563454002 cites W2169543500 @default.
• W1563454002 cites W4238748856 @default.
• W1563454002 cites W4245478173 @default.
• W1563454002 doi "https://doi.org/10.3390/ijms160612943" @default.
• W1563454002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4490480" @default.
• W1563454002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26062131" @default.
• W1563454002 hasPublicationYear "2015" @default.
• W1563454002 type Work @default.
• W1563454002 sameAs 1563454002 @default.
• W1563454002 citedByCount "79" @default.
• W1563454002 countsByYear W15634540022015 @default.
• W1563454002 countsByYear W15634540022016 @default.
• W1563454002 countsByYear W15634540022017 @default.
• W1563454002 countsByYear W15634540022018 @default.
• W1563454002 countsByYear W15634540022019 @default.
• W1563454002 countsByYear W15634540022020 @default.
• W1563454002 countsByYear W15634540022021 @default.
• W1563454002 countsByYear W15634540022022 @default.
• W1563454002 countsByYear W15634540022023 @default.
• W1563454002 crossrefType "journal-article" @default.
• W1563454002 hasAuthorship W1563454002A5049012342 @default.
• W1563454002 hasAuthorship W1563454002A5062257507 @default.
• W1563454002 hasAuthorship W1563454002A5090972511 @default.
• W1563454002 hasBestOaLocation W15634540021 @default.
• W1563454002 hasConcept C104317684 @default.
• W1563454002 hasConcept C159047783 @default.
• W1563454002 hasConcept C194857396 @default.

• next