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- W1563533178 abstract "A quantitative relationship between the efficacy (i.e. maximum enhancement) of Cl − to increase [ 3 H]flunitrazepam binding and the density of [ 35 S] -t- butylbicyclophosphorothionate binding sites was observed in well-washed membrane fragments of rat cerebral cortex previously exposed to phospholipase A 2 . This relationship (described by the equation y = AB x ) was maintained when [ 3 H]flunitrazepam was assayed at Cl − concentrations between 100 and 600 mM, and was not qualitatively altered by the presence of 100 μM pentobarbital. However, under experimental conditions that reduced the ratio of [ 35 S]TBPS binding sites/benzodiazepine receptors, the effects of pentobarbital suggest that the conductance state of benzodiazepine receptor-coupled chloride channels may be the primary determinant of Cl − enhanced [ 3 H]flunitrazepam binding." @default.
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- W1563533178 date "1986-12-01" @default.
- W1563533178 modified "2023-09-26" @default.
- W1563533178 title "A quantitative relationship between Cl− enhanced [3H]flunitrazepam and binding to the benzodiazepine/GABA receptor chloride ionophore complex" @default.
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- W1563533178 doi "https://doi.org/10.1016/0169-328x(86)90034-3" @default.
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