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• W1563581895 abstract "Harman's Free Radical Theory of Aging has been considered as a major theory of aging for more than 50 years. In 1956 Dr. Harman proposed that the accumulation of free radicals with the age causes the damage of biomolecules by these reactive species and the development of pathological disorders resulting in cell senescence and organismal aging. His hypothesis was supported by numerous experimental studies demonstrated an increase in free radical levels in cells and living organisms with aging. In subsequent years important discoveries of new physiological free radicals superoxide and nitric oxide have been made that led to understanding of other important functions of free radicals. It has been shown that superoxide and nitric oxide together with their diamagnetic reaction products hydrogen peroxide and peroxynitrite (all are now named reactive oxygen and nitrogen species, ROS and RNS) function as signaling species in many physiological enzymatic/gene processes. Furthermore, the disturbance of ROS and RNS physiological signaling can be an origin of various pathologies and aging. These discoveries demanded to widen original free radical theory of aging and to consider the damaging ROS signaling as an important, maybe major route to cell senescence and organismal aging. However, some experimental findings such as the extension of lifespan by calorie restriction of yeast, flies, worms, and mice, and favorable effects of physical exercises stimulated criticism of free radical theory because the expansion of lifespan accompanied in some cases by increasing oxidative stress. On these grounds such theories as Hormesis and Target of rapamycin (mTOR) theories refute the role of ROS and oxidative stress in aging. Accordingly, a major purpose of this review to show that ROS signaling is probably the most important enzyme/gene pathway responsible for the development of cell senescence and organismal aging and that ROS signaling might be considered as further development of free radical theory of aging. In spite of apparent contradictions the Hormesis or TOR theories are also describing processes of aging development regulated by ROS signaling." @default.
• W1563581895 created "2016-06-24" @default.
• W1563581895 creator A5014501806 @default.
• W1563581895 date "2010-10-01" @default.
• W1563581895 modified "2023-10-17" @default.
• W1563581895 title "Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR." @default.
• W1563581895 cites W1500094241 @default.
• W1563581895 cites W15212789 @default.
• W1563581895 cites W1523497097 @default.
• W1563581895 cites W1550849850 @default.
• W1563581895 cites W1556889952 @default.
• W1563581895 cites W1568261465 @default.
• W1563581895 cites W1573222602 @default.
• W1563581895 cites W1575889803 @default.
• W1563581895 cites W1887679324 @default.
• W1563581895 cites W1967172766 @default.
• W1563581895 cites W1967644266 @default.
• W1563581895 cites W1967854462 @default.
• W1563581895 cites W1974954009 @default.
• W1563581895 cites W1978216018 @default.
• W1563581895 cites W1980708686 @default.
• W1563581895 cites W1984628764 @default.
• W1563581895 cites W1987808754 @default.
• W1563581895 cites W1988085199 @default.
• W1563581895 cites W1989159550 @default.
• W1563581895 cites W1993313236 @default.
• W1563581895 cites W1995746533 @default.
• W1563581895 cites W1997225393 @default.
• W1563581895 cites W2000303677 @default.
• W1563581895 cites W2000730064 @default.
• W1563581895 cites W2004129180 @default.
• W1563581895 cites W2009764032 @default.
• W1563581895 cites W2014320780 @default.
• W1563581895 cites W2016244372 @default.
• W1563581895 cites W2017109096 @default.
• W1563581895 cites W2019063477 @default.
• W1563581895 cites W2024013299 @default.
• W1563581895 cites W2024391299 @default.
• W1563581895 cites W2025325991 @default.
• W1563581895 cites W2025674512 @default.
• W1563581895 cites W2031004588 @default.
• W1563581895 cites W2031095920 @default.
• W1563581895 cites W2036520729 @default.
• W1563581895 cites W2043043038 @default.
• W1563581895 cites W2043096460 @default.
• W1563581895 cites W2049231450 @default.
• W1563581895 cites W2050434504 @default.
• W1563581895 cites W2052244692 @default.
• W1563581895 cites W2054478143 @default.
• W1563581895 cites W2060369591 @default.
• W1563581895 cites W2062502922 @default.
• W1563581895 cites W2063621787 @default.
• W1563581895 cites W2065841968 @default.
• W1563581895 cites W2066739146 @default.
• W1563581895 cites W2071777299 @default.
• W1563581895 cites W2071864606 @default.
• W1563581895 cites W2080094749 @default.
• W1563581895 cites W2081878182 @default.
• W1563581895 cites W2083718982 @default.
• W1563581895 cites W2086027234 @default.
• W1563581895 cites W2092236038 @default.
• W1563581895 cites W2095905550 @default.
• W1563581895 cites W2097738382 @default.
• W1563581895 cites W2098442982 @default.
• W1563581895 cites W2098774492 @default.
• W1563581895 cites W2100718398 @default.
• W1563581895 cites W2101347477 @default.
• W1563581895 cites W2104831093 @default.
• W1563581895 cites W2105276425 @default.
• W1563581895 cites W2108209937 @default.
• W1563581895 cites W2109944869 @default.
• W1563581895 cites W2113007696 @default.
• W1563581895 cites W2113216706 @default.
• W1563581895 cites W2113275211 @default.
• W1563581895 cites W2115709321 @default.
• W1563581895 cites W2117396891 @default.
• W1563581895 cites W2118204731 @default.
• W1563581895 cites W2118874116 @default.
• W1563581895 cites W2122226194 @default.
• W1563581895 cites W2124561899 @default.
• W1563581895 cites W2129529988 @default.
• W1563581895 cites W2133904259 @default.
• W1563581895 cites W2135811448 @default.
• W1563581895 cites W2137720344 @default.
• W1563581895 cites W2150381945 @default.
• W1563581895 cites W2152875073 @default.
• W1563581895 cites W2165209574 @default.
• W1563581895 cites W2170480231 @default.
• W1563581895 cites W2186647212 @default.
• W1563581895 cites W2209317426 @default.
• W1563581895 cites W2315512556 @default.
• W1563581895 cites W2328897884 @default.
• W1563581895 cites W70664813 @default.
• W1563581895 cites W80953942 @default.
• W1563581895 cites W2398907556 @default.
• W1563581895 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3295029" @default.
• W1563581895 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22396858" @default.
• W1563581895 hasPublicationYear "2010" @default.
• W1563581895 type Work @default.
• W1563581895 sameAs 1563581895 @default.

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