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- W156358845 abstract "The banded pattern of DNA sequence differences along the mammalian chromosome reflects the chromosome’s history of fixed mutations. It cannot be explained by random mutational input followed by natural selection acting to discard disadvantageous mutations. Rather, it must involve ordered mutational input followed by random drift with little selection. Molecular ecology is the study of mutational input organized congruent to the banding pattern. It is the study of local mutational biases which organize communities of positionally constrained DNA. The biased mutational input is not limited to non-coding DNA; even some aspects of exon sequences are more determined by where a gene lives than by what it does. Here, we show that several primary mutational events do occur congruent to the banding pattern. X-ray-induced breaks and breaks fixed during primate evolution are most prevalent in T-bands. T-bands comprise 15% of all bands and contain extremely GC-rich DNA. Bloom syndrome mitotic chiasmata are most prevalent in the 13% of the bands characterized by high sequence concentrations of the Alu retroposon. Melphalan-induced breaks are near both T-bands and vAlu+ bands." @default.
- W156358845 created "2016-06-24" @default.
- W156358845 creator A5028042005 @default.
- W156358845 date "1990-01-01" @default.
- W156358845 modified "2023-09-25" @default.
- W156358845 title "Mutational Bias, Molecular Ecology, and Chromosome Evolution" @default.
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- W156358845 doi "https://doi.org/10.1007/978-3-642-75599-6_3" @default.
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