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• W1563614090 startingPage "163" @default.
• W1563614090 abstract "Clinical and animal studies indicate that maternal consumption of ethanol during pregnancy increases alcohol drinking in the offspring. Possible underlying mechanisms may involve orexigenic peptides, which are stimulated by prenatal ethanol exposure and themselves promote drinking. Building on evidence that ethanol stimulates neuroimmune factors such as the chemokine CCL2 that in adult rats is shown to colocalize with the orexigenic peptide, melanin-concentrating hormone (MCH) in the lateral hypothalamus (LH), the present study sought to investigate the possibility that CCL2 or its receptor CCR2 in LH is stimulated by prenatal ethanol exposure, perhaps specifically within MCH neurons. Our paradigm of intraoral administration of ethanol to pregnant rats, at low-to-moderate doses (1 or 3g/kg/day) during peak hypothalamic neurogenesis, caused in adolescent male offspring twofold increase in drinking of and preference for ethanol and reinstatement of ethanol drinking in a two-bottle choice paradigm under an intermittent access schedule. This effect of prenatal ethanol exposure was associated with an increased expression of MCH and density of MCH(+) neurons in LH of preadolescent offspring. Whereas CCL2(+) cells at this age were low in density and unaffected by ethanol, CCR2(+) cells were dense in LH and increased by prenatal ethanol, with a large percentage (83-87%) identified as neurons and found to colocalize MCH. Prenatal ethanol also stimulated the genesis of CCR2(+) and MCH(+) neurons in the embryo, which co-labeled the proliferation marker, BrdU. Ethanol also increased the genesis and density of neurons that co-expressed CCR2 and MCH in LH, with triple-labeled CCR2(+)/MCH(+)/BrdU(+) neurons that were absent in control rats accounting for 35% of newly generated neurons in ethanol-exposed rats. With both the chemokine and MCH systems believed to promote ethanol consumption, this greater density of CCR2(+)/MCH(+) neurons in the LH of preadolescent rats suggests that these systems function together in promoting alcohol drinking during adolescence." @default.
• W1563614090 created "2016-06-24" @default.
• W1563614090 creator A5016800957 @default.
• W1563614090 creator A5028898765 @default.
• W1563614090 creator A5090507281 @default.
• W1563614090 date "2015-12-01" @default.
• W1563614090 modified "2023-10-01" @default.
• W1563614090 title "Prenatal exposure to ethanol stimulates hypothalamic CCR2 chemokine receptor system: Possible relation to increased density of orexigenic peptide neurons and ethanol drinking in adolescent offspring" @default.
• W1563614090 cites W1489379035 @default.
• W1563614090 cites W1510989612 @default.
• W1563614090 cites W1526855917 @default.
• W1563614090 cites W1596260790 @default.
• W1563614090 cites W1656741156 @default.
• W1563614090 cites W1963997891 @default.
• W1563614090 cites W1969866098 @default.
• W1563614090 cites W1970964326 @default.
• W1563614090 cites W1975684351 @default.
• W1563614090 cites W1976421149 @default.
• W1563614090 cites W1977546136 @default.
• W1563614090 cites W1977707278 @default.
• W1563614090 cites W1981021551 @default.
• W1563614090 cites W1983955342 @default.
• W1563614090 cites W1985399027 @default.
• W1563614090 cites W1989375959 @default.
• W1563614090 cites W1990621985 @default.
• W1563614090 cites W1991517861 @default.
• W1563614090 cites W1998419939 @default.
• W1563614090 cites W1998889926 @default.
• W1563614090 cites W2000471946 @default.
• W1563614090 cites W2003964453 @default.
• W1563614090 cites W2006624547 @default.
• W1563614090 cites W2009962309 @default.
• W1563614090 cites W2010829605 @default.
• W1563614090 cites W2011000155 @default.
• W1563614090 cites W2011365147 @default.
• W1563614090 cites W2011464032 @default.
• W1563614090 cites W2011674713 @default.
• W1563614090 cites W2014366175 @default.
• W1563614090 cites W2017305439 @default.
• W1563614090 cites W2018062658 @default.
• W1563614090 cites W2025846355 @default.
• W1563614090 cites W2026058875 @default.
• W1563614090 cites W2034798927 @default.
• W1563614090 cites W2038768224 @default.
• W1563614090 cites W2039807078 @default.
• W1563614090 cites W2040900588 @default.
• W1563614090 cites W2041095734 @default.
• W1563614090 cites W2041680657 @default.
• W1563614090 cites W2041776284 @default.
• W1563614090 cites W2044879201 @default.
• W1563614090 cites W2046683337 @default.
• W1563614090 cites W2047161171 @default.
• W1563614090 cites W2050082668 @default.
• W1563614090 cites W2055251709 @default.
• W1563614090 cites W2055904800 @default.
• W1563614090 cites W2064453868 @default.
• W1563614090 cites W2064891273 @default.
• W1563614090 cites W2067138327 @default.
• W1563614090 cites W2068330961 @default.
• W1563614090 cites W2068958030 @default.
• W1563614090 cites W2069790224 @default.
• W1563614090 cites W2070250054 @default.
• W1563614090 cites W2070795670 @default.
• W1563614090 cites W2075198227 @default.
• W1563614090 cites W2075648755 @default.
• W1563614090 cites W2078490108 @default.
• W1563614090 cites W2081609922 @default.
• W1563614090 cites W2083621819 @default.
• W1563614090 cites W2083806868 @default.
• W1563614090 cites W2087173041 @default.
• W1563614090 cites W2087994176 @default.
• W1563614090 cites W2091389527 @default.
• W1563614090 cites W2093352510 @default.
• W1563614090 cites W2097498503 @default.
• W1563614090 cites W2098122723 @default.
• W1563614090 cites W2109981949 @default.
• W1563614090 cites W2111765237 @default.
• W1563614090 cites W2112087489 @default.
• W1563614090 cites W2119137469 @default.
• W1563614090 cites W2124276367 @default.
• W1563614090 cites W2129898723 @default.
• W1563614090 cites W2134638178 @default.
• W1563614090 cites W2137554480 @default.
• W1563614090 cites W2139800253 @default.
• W1563614090 cites W2143295652 @default.
• W1563614090 cites W2148248504 @default.
• W1563614090 cites W2150814034 @default.
• W1563614090 cites W2153359958 @default.
• W1563614090 cites W2154537507 @default.
• W1563614090 cites W2163522951 @default.
• W1563614090 cites W2164377475 @default.
• W1563614090 cites W2164595661 @default.
• W1563614090 cites W2170225187 @default.
• W1563614090 cites W2171748387 @default.
• W1563614090 cites W2472302462 @default.
• W1563614090 doi "https://doi.org/10.1016/j.neuroscience.2015.09.020" @default.
• W1563614090 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4633395" @default.
• W1563614090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26365610" @default.

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