FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1563673517> ?p ?o ?g. }

• W1563673517 endingPage "2415" @default.
• W1563673517 startingPage "2405" @default.
• W1563673517 abstract "Dendritic cells (DCs) are crucial to intestinal immune regulation because of their roles in inducing protective immunity against pathogens while maintaining tolerance to commensal bacteria. Nonetheless, relatively little is known about intestinal DC responsiveness to innate immune stimuli via TLRs. We have previously shown that DCs migrating from the rat intestine in lymph (iLDCs) are hyporesponsive to LPS stimulation, thus possibly preventing harmful immune responses being induced to commensal flora. In this study, to understand how iLDC function is regulated by innate immune stimuli, we have characterized the expression and function of TLRs in iLDCs isolated from the thoracic duct lymph of mesenteric lymphadenectomized rats and compared these with DCs grown from bone marrow in the presence of Flt3 ligand. We show that iLDCs express mRNAs for all TLRs, but express significantly less TLR4 mRNA than bone marrow-derived DCs. Functionally, iLDCs could be activated by TLR agonists representing intestinal pathogen-associated molecular patterns, with the important exception of the TLR4 agonist LPS. Furthermore, we show that DCs in the intestinal wall interact directly with noninvasive bacteria (Bacillus subtilis spores), leading to an increase in the output of activated iLDCs into lymph, and that DCs containing spores are activated selectively. These data highlight a functional difference between TLR4 and other TLRs. As iLDCs can respond to TLR stimulation in vitro, there must be other mechanisms that prevent their activation by commensal bacteria under steady-state conditions." @default.
• W1563673517 created "2016-06-24" @default.
• W1563673517 creator A5006935754 @default.
• W1563673517 creator A5015338528 @default.
• W1563673517 creator A5018142060 @default.
• W1563673517 creator A5025873953 @default.
• W1563673517 creator A5039066309 @default.
• W1563673517 creator A5057280668 @default.
• W1563673517 date "2009-02-06" @default.
• W1563673517 modified "2023-10-10" @default.
• W1563673517 title "Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4" @default.
• W1563673517 cites W1514955262 @default.
• W1563673517 cites W1525912444 @default.
• W1563673517 cites W1578114463 @default.
• W1563673517 cites W1769928764 @default.
• W1563673517 cites W1845975704 @default.
• W1563673517 cites W1944936670 @default.
• W1563673517 cites W1967973923 @default.
• W1563673517 cites W1972473113 @default.
• W1563673517 cites W1973834362 @default.
• W1563673517 cites W1981087308 @default.
• W1563673517 cites W1986665945 @default.
• W1563673517 cites W1987917362 @default.
• W1563673517 cites W1991961045 @default.
• W1563673517 cites W1999660917 @default.
• W1563673517 cites W2000952771 @default.
• W1563673517 cites W2003151745 @default.
• W1563673517 cites W2005998335 @default.
• W1563673517 cites W2009112167 @default.
• W1563673517 cites W2032793030 @default.
• W1563673517 cites W2035506432 @default.
• W1563673517 cites W2038073973 @default.
• W1563673517 cites W2043999480 @default.
• W1563673517 cites W2044520532 @default.
• W1563673517 cites W2045994657 @default.
• W1563673517 cites W2059839808 @default.
• W1563673517 cites W2065927080 @default.
• W1563673517 cites W2083089709 @default.
• W1563673517 cites W2089800177 @default.
• W1563673517 cites W2090640877 @default.
• W1563673517 cites W2102130872 @default.
• W1563673517 cites W2105221079 @default.
• W1563673517 cites W2108985104 @default.
• W1563673517 cites W2110161909 @default.
• W1563673517 cites W2110957620 @default.
• W1563673517 cites W2117395989 @default.
• W1563673517 cites W2127035465 @default.
• W1563673517 cites W2128444087 @default.
• W1563673517 cites W2128712834 @default.
• W1563673517 cites W2132640237 @default.
• W1563673517 cites W2134372103 @default.
• W1563673517 cites W2141357989 @default.
• W1563673517 cites W2148222156 @default.
• W1563673517 cites W2148579227 @default.
• W1563673517 cites W2157339124 @default.
• W1563673517 cites W2161354474 @default.
• W1563673517 cites W2162012576 @default.
• W1563673517 cites W2164317756 @default.
• W1563673517 cites W2165199797 @default.
• W1563673517 cites W2171980652 @default.
• W1563673517 cites W2254387472 @default.
• W1563673517 cites W4232800232 @default.
• W1563673517 cites W4234615218 @default.
• W1563673517 doi "https://doi.org/10.4049/jimmunol.0802318" @default.
• W1563673517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19201895" @default.
• W1563673517 hasPublicationYear "2009" @default.
• W1563673517 type Work @default.
• W1563673517 sameAs 1563673517 @default.
• W1563673517 citedByCount "47" @default.
• W1563673517 countsByYear W15636735172012 @default.
• W1563673517 countsByYear W15636735172013 @default.
• W1563673517 countsByYear W15636735172014 @default.
• W1563673517 countsByYear W15636735172015 @default.
• W1563673517 countsByYear W15636735172016 @default.
• W1563673517 countsByYear W15636735172017 @default.
• W1563673517 countsByYear W15636735172018 @default.
• W1563673517 countsByYear W15636735172020 @default.
• W1563673517 countsByYear W15636735172021 @default.
• W1563673517 countsByYear W15636735172022 @default.
• W1563673517 countsByYear W15636735172023 @default.
• W1563673517 crossrefType "journal-article" @default.
• W1563673517 hasAuthorship W1563673517A5006935754 @default.
• W1563673517 hasAuthorship W1563673517A5015338528 @default.
• W1563673517 hasAuthorship W1563673517A5018142060 @default.
• W1563673517 hasAuthorship W1563673517A5025873953 @default.
• W1563673517 hasAuthorship W1563673517A5039066309 @default.
• W1563673517 hasAuthorship W1563673517A5057280668 @default.
• W1563673517 hasBestOaLocation W15636735171 @default.
• W1563673517 hasConcept C136449434 @default.
• W1563673517 hasConcept C169760540 @default.
• W1563673517 hasConcept C193419808 @default.
• W1563673517 hasConcept C203014093 @default.
• W1563673517 hasConcept C24998067 @default.
• W1563673517 hasConcept C2776070231 @default.
• W1563673517 hasConcept C2778170410 @default.
• W1563673517 hasConcept C2779237934 @default.
• W1563673517 hasConcept C2779341262 @default.
• W1563673517 hasConcept C2781236682 @default.

• next