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- W1563846350 abstract "In vivo labeling kinetics of (a) nascent peptides on liver polysomes, and (b) proteins of the 100 000 × g supernatant have been determined for animals treated with ethionine, or cycloheximide. When compared to computer generated date, the results indicate that (a) ethionine inhibits protein synthesis by reducing the rate of initiation and (b) cycloheximide inhibits protein synthesis by reducing the rate of elongation. An in vivo approach is presented which indicates the regulatory parameter (rate of initiation, elongation or termination) most affected when the rate of protein synthesis is altered. The approach is applicable to many other experimental situations, using the intact animal, in which protein synthesis is altered by endogenous factors, or upset by exogenous agents or disease processes." @default.
- W1563846350 created "2016-06-24" @default.
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- W1563846350 date "1972-07-01" @default.
- W1563846350 modified "2023-10-14" @default.
- W1563846350 title "The regulatory parameter of protein synthesis most affected by ethionine, and cycloheximide" @default.
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- W1563846350 doi "https://doi.org/10.1016/0005-2787(72)90398-x" @default.
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