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• W1563847719 endingPage "2339" @default.
• W1563847719 startingPage "2335" @default.
• W1563847719 abstract "Hematopoietic cells of the Japanese quail were transformed by avian erythroblastosis virus in vivo and in vitro. In both circumstances, the infected hematopoietic tissues exhibited a dual oncogenic response of erythroid and mast cell-basophil elements. The erythroid transformants escaped the avian erythroblastosis virus block in differentiation and progressed to hemoglobinization. Resulting basophilic cells were morphologically, biochemically, and ultrastructurally identical to mast cell-basophils observed in other species. None of the virally transformed cells actively produced reverse transcriptase activity. Nonproducer cell lines synthesized viral RNA and both v-erbA and v-erbB proteins. These results indicate that the Japanese quail has a viral target cell different from that of the chicken. The implications of a single bipotential transformation target yielding both erythroid and mast cell-basophil colonies is discussed." @default.
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• W1563847719 date "1989-05-01" @default.
• W1563847719 modified "2023-09-27" @default.
• W1563847719 title "Avian erythroblastosis virus transforms a novel mast cell-basophil precursor target in the Japanese quail" @default.
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• W1563847719 doi "https://doi.org/10.1128/jvi.63.5.2335-2339.1989" @default.
• W1563847719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/250652" @default.
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