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• W1563860173 abstract "Inflammatory cell and cytokine cascade activation is present in humans with alcoholic liver disease as well as in animal models of alcohol-induced liver damage. Gut-derived lipopolysaccharide (LPS), a ligand of the Toll-like receptor 4 (TLR4), plays a central role in triggering and maintaining activation of Kupffer cells in alcoholic hepatitis. In this mini-review, we describe molecular mechanisms that lead to increased inflammatory cell activation by alcohol and LPS and discuss the mechanism for activation in alcohol-exposed macrophages. In alcohol-induced liver disease we discuss the role of MyD88-independent but IRF3-mediated TLR4 signaling in alcohol-related liver inflammation and liver damage." @default.
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• W1563860173 date "2011-02-01" @default.
• W1563860173 modified "2023-10-03" @default.
• W1563860173 title "The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury" @default.
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• W1563860173 doi "https://doi.org/10.1111/j.1530-0277.2010.01398.x" @default.
• W1563860173 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742381" @default.
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