FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1563963651> ?p ?o ?g. }

• W1563963651 endingPage "e0128317" @default.
• W1563963651 startingPage "e0128317" @default.
• W1563963651 abstract "Meiotic errors during oocyte maturation are considered the major contributors to embryonic aneuploidy and failures in human IVF treatment. Various technologies have been developed to screen polar bodies, blastomeres and trophectoderm cells for chromosomal aberrations. Array-CGH analysis using bacterial artificial chromosome (BAC) arrays is widely applied for preimplantation genetic diagnosis (PGD) using single cells. Recently, an increase in the pregnancy rate has been demonstrated using array-CGH to evaluate trophectoderm cells. However, in some countries, the analysis of embryonic cells is restricted by law. Therefore, we used BAC array-CGH to assess the impact of polar body analysis on the live birth rate. A disadvantage of polar body aneuploidy screening is the necessity of the analysis of both the first and second polar bodies, resulting in increases in costs for the patient and complex data interpretation. Aneuploidy screening results may sometimes be ambiguous if the first and second polar bodies show reciprocal chromosomal aberrations. To overcome this disadvantage, we tested a strategy involving the pooling of DNA from both polar bodies before DNA amplification. We retrospectively studied 351 patients, of whom 111 underwent polar body array-CGH before embryo transfer. In the group receiving pooled polar body array-CGH (aCGH) analysis, 110 embryos were transferred, and 29 babies were born, corresponding to live birth rates of 26.4% per embryo and 35.7% per patient. In contrast, in the control group, the IVF treatment was performed without preimplantation genetic screening (PGS). For this group, 403 embryos were transferred, and 60 babies were born, resulting in live birth rates of 14.9% per embryo and 22.7% per patient. In conclusion, our data show that in the aCGH group, the use of aneuploidy screening resulted in a significantly higher live birth rate compared with the control group, supporting the benefit of PGS for IVF couples in addition to the suitability and effectiveness of our polar body pooling strategy." @default.
• W1563963651 created "2016-06-24" @default.
• W1563963651 creator A5014226683 @default.
• W1563963651 creator A5019311635 @default.
• W1563963651 creator A5024095677 @default.
• W1563963651 creator A5025032130 @default.
• W1563963651 creator A5042208061 @default.
• W1563963651 creator A5052076982 @default.
• W1563963651 creator A5053900356 @default.
• W1563963651 creator A5057205306 @default.
• W1563963651 creator A5065871400 @default.
• W1563963651 creator A5077751626 @default.
• W1563963651 creator A5080823106 @default.
• W1563963651 date "2015-05-29" @default.
• W1563963651 modified "2023-10-18" @default.
• W1563963651 title "Increasing Live Birth Rate by Preimplantation Genetic Screening of Pooled Polar Bodies Using Array Comparative Genomic Hybridization" @default.
• W1563963651 cites W1529934215 @default.
• W1563963651 cites W1977904422 @default.
• W1563963651 cites W1980829763 @default.
• W1563963651 cites W1985356535 @default.
• W1563963651 cites W1992679265 @default.
• W1563963651 cites W1994558154 @default.
• W1563963651 cites W2001427221 @default.
• W1563963651 cites W2009826731 @default.
• W1563963651 cites W2011238217 @default.
• W1563963651 cites W2030794145 @default.
• W1563963651 cites W2033911590 @default.
• W1563963651 cites W2054161279 @default.
• W1563963651 cites W2058843560 @default.
• W1563963651 cites W2062608141 @default.
• W1563963651 cites W2069601513 @default.
• W1563963651 cites W2076066501 @default.
• W1563963651 cites W2076678704 @default.
• W1563963651 cites W2081213729 @default.
• W1563963651 cites W2085314753 @default.
• W1563963651 cites W2094332692 @default.
• W1563963651 cites W2095666069 @default.
• W1563963651 cites W2103836463 @default.
• W1563963651 cites W2104658942 @default.
• W1563963651 cites W2109501305 @default.
• W1563963651 cites W2109682665 @default.
• W1563963651 cites W2112774354 @default.
• W1563963651 cites W2113714439 @default.
• W1563963651 cites W2114127762 @default.
• W1563963651 cites W2116073351 @default.
• W1563963651 cites W2119601984 @default.
• W1563963651 cites W2120080197 @default.
• W1563963651 cites W2128972377 @default.
• W1563963651 cites W2130665570 @default.
• W1563963651 cites W2131300747 @default.
• W1563963651 cites W2132147408 @default.
• W1563963651 cites W2132470016 @default.
• W1563963651 cites W2133381977 @default.
• W1563963651 cites W2135290162 @default.
• W1563963651 cites W2143262731 @default.
• W1563963651 cites W2144930693 @default.
• W1563963651 cites W2145723292 @default.
• W1563963651 cites W2147121501 @default.
• W1563963651 cites W2147815082 @default.
• W1563963651 cites W2148284355 @default.
• W1563963651 cites W2150211084 @default.
• W1563963651 cites W2163775540 @default.
• W1563963651 cites W2164496136 @default.
• W1563963651 cites W2168168501 @default.
• W1563963651 cites W2169326644 @default.
• W1563963651 cites W2260219053 @default.
• W1563963651 cites W2327262500 @default.
• W1563963651 cites W2599076725 @default.
• W1563963651 cites W4236948386 @default.
• W1563963651 cites W4248429808 @default.
• W1563963651 cites W4322695930 @default.
• W1563963651 doi "https://doi.org/10.1371/journal.pone.0128317" @default.
• W1563963651 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4503526" @default.
• W1563963651 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26176533" @default.
• W1563963651 hasPublicationYear "2015" @default.
• W1563963651 type Work @default.
• W1563963651 sameAs 1563963651 @default.
• W1563963651 citedByCount "22" @default.
• W1563963651 countsByYear W15639636512015 @default.
• W1563963651 countsByYear W15639636512016 @default.
• W1563963651 countsByYear W15639636512017 @default.
• W1563963651 countsByYear W15639636512018 @default.
• W1563963651 countsByYear W15639636512020 @default.
• W1563963651 countsByYear W15639636512022 @default.
• W1563963651 countsByYear W15639636512023 @default.
• W1563963651 crossrefType "journal-article" @default.
• W1563963651 hasAuthorship W1563963651A5014226683 @default.
• W1563963651 hasAuthorship W1563963651A5019311635 @default.
• W1563963651 hasAuthorship W1563963651A5024095677 @default.
• W1563963651 hasAuthorship W1563963651A5025032130 @default.
• W1563963651 hasAuthorship W1563963651A5042208061 @default.
• W1563963651 hasAuthorship W1563963651A5052076982 @default.
• W1563963651 hasAuthorship W1563963651A5053900356 @default.
• W1563963651 hasAuthorship W1563963651A5057205306 @default.
• W1563963651 hasAuthorship W1563963651A5065871400 @default.
• W1563963651 hasAuthorship W1563963651A5077751626 @default.
• W1563963651 hasAuthorship W1563963651A5080823106 @default.
• W1563963651 hasBestOaLocation W15639636511 @default.

• next