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• W1564025648 abstract "The stringent response, mediated by second messenger (p)ppGpp, results in swift and massive transcriptional reprogramming under nutrient limited conditions. In this study, the role of (p)ppGpp on virulence of Pseudomonas syringae pv. syringae B728a (PssB728a) was investigated. The virulence of the relA/spoT (ppGpp(0) ) double mutant was completely impaired on bean, and bacterial growth was significantly reduced, suggesting that (p)ppGpp is required for full virulence of P. syringae. Expression of T3SS and other virulence genes was reduced in ppGpp(0) mutants. In addition, ppGpp deficiency resulted in loss of swarming motility, reduction of pyoverdine production, increased sensitivity to oxidative stress and antibiotic tolerance, as well as reduced ability to utilize γ-amino butyric acid. Increased levels of ppGpp resulted in reduced cell size of PssB728a when grown in a minimal medium and on plant surfaces, while most ppGpp(0) mutant cells were not viable on plant surfaces 24 h after spray inoculation, suggesting that ppGpp-mediated stringent response temporarily limits cell growth, and might control cell survival on plants by limiting their growth. These results demonstrated that ppGpp-mediated stringent response plays a central role in P. syringae virulence and survival and indicated that ppGpp serves as a global signal for regulating various virulence traits in PssB728a." @default.
• W1564025648 created "2016-06-24" @default.
• W1564025648 creator A5029662138 @default.
• W1564025648 creator A5037871020 @default.
• W1564025648 creator A5062581730 @default.
• W1564025648 creator A5065233089 @default.
• W1564025648 date "2015-03-04" @default.
• W1564025648 modified "2023-10-16" @default.
• W1564025648 title "The bacterial alarmone (<scp>p</scp>)<scp>ppGpp</scp> is required for virulence and controls cell size and survival of <scp><i>P</i></scp><i>seudomonas syringae</i> on plants" @default.
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• W1564025648 doi "https://doi.org/10.1111/1462-2920.12744" @default.
• W1564025648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4758678" @default.
• W1564025648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25626964" @default.

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