FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1564129188> ?p ?o ?g. }

• W1564129188 endingPage "591" @default.
• W1564129188 startingPage "582" @default.
• W1564129188 abstract "Cite this as: K. Srivastava, N. Yang, Y. Chen, I. Lopez‐Exposito, Y. Song, J. Goldfarb, J. Zhan, H. Sampson and X‐M. Li, Clinical & Experimental Allergy, 2011 (41) 582–591. Summary Background Therapies for peanut allergy (PNA) are urgently needed. Food Allergy Herbal Formula‐2 (FAHF‐2) has profound therapeutic effects in a murine PNA model and is safe for food‐allergic adults in clinical trials. However, the large FAHF‐2 pill‐load is not conducive to clinical studies in children. Thus, refining FAHF‐2 to decrease pill‐load is essential for the inclusion of children in clinical trials and to facilitate studying FAHF‐2 as a clinically useful botanical drug. Objectives Testing long‐term efficacy and safety of a butanol‐purified extract of FAHF‐2 (B‐FAHF‐2) in a murine model of PNA, and to explore its immunological mechanisms of action. Methods FAHF‐2 was purified by butanol extraction. C3H/HeJ mice with established PNA received the first course of B‐FAHF‐2 at 6 mg, twice daily for 7 weeks (PNA/B‐FAHF‐2) or water (PNA/sham) and were then challenged immediately after completing the treatment and six more times every 1–2 months post‐treatment up to week 50. Mice then received a second course of B‐FAHF‐2 treatment at week 52 and were challenged at week 65. In vivo and in vitro immunological effects on T, B and mast cells were also determined. Results Butanol purification reduced the volume of the effective dose ∼5‐fold. All PNA/B‐FAHF‐2 mice were completely protected from PN anaphylaxis until the fifth challenge after the first course of treatment, as compared with PNA/sham mice. Partial protection persisted up to 50 weeks. A second treatment course restored complete protection. B‐FAHF‐2 significantly suppressed Th2 cytokine, IgE and histamine levels in vivo , and showed direct inhibition of Th2, IgE‐producing B cells and mast cell activation in vitro . B‐FAHF‐2 had a high margin of safety. Conclusion and Clinical Relevance B‐FAHF‐2 produced long‐lasting protection against PN anaphylaxis for approximately half of the murine life span without side‐effects. B‐FAHF‐2 exhibited direct effects on multiple food allergy effector cells." @default.
• W1564129188 created "2016-06-24" @default.
• W1564129188 creator A5004117880 @default.
• W1564129188 creator A5012898979 @default.
• W1564129188 creator A5015552885 @default.
• W1564129188 creator A5026369750 @default.
• W1564129188 creator A5036740014 @default.
• W1564129188 creator A5041764652 @default.
• W1564129188 creator A5050170161 @default.
• W1564129188 creator A5062824684 @default.
• W1564129188 creator A5071319432 @default.
• W1564129188 date "2010-12-01" @default.
• W1564129188 modified "2023-10-17" @default.
• W1564129188 title "Efficacy, safety and immunological actions of butanol-extracted Food Allergy Herbal Formula-2 on peanut anaphylaxis" @default.
• W1564129188 cites W1990335585 @default.
• W1564129188 cites W1994095603 @default.
• W1564129188 cites W2007908335 @default.
• W1564129188 cites W2020237884 @default.
• W1564129188 cites W2033693280 @default.
• W1564129188 cites W2035509827 @default.
• W1564129188 cites W2048225817 @default.
• W1564129188 cites W2090753268 @default.
• W1564129188 cites W2096674600 @default.
• W1564129188 cites W2100042048 @default.
• W1564129188 cites W2166046338 @default.
• W1564129188 cites W4251404231 @default.
• W1564129188 doi "https://doi.org/10.1111/j.1365-2222.2010.03643.x" @default.
• W1564129188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3059750" @default.
• W1564129188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21121976" @default.
• W1564129188 hasPublicationYear "2010" @default.
• W1564129188 type Work @default.
• W1564129188 sameAs 1564129188 @default.
• W1564129188 citedByCount "26" @default.
• W1564129188 countsByYear W15641291882012 @default.
• W1564129188 countsByYear W15641291882013 @default.
• W1564129188 countsByYear W15641291882014 @default.
• W1564129188 countsByYear W15641291882015 @default.
• W1564129188 countsByYear W15641291882017 @default.
• W1564129188 countsByYear W15641291882018 @default.
• W1564129188 countsByYear W15641291882021 @default.
• W1564129188 countsByYear W15641291882022 @default.
• W1564129188 countsByYear W15641291882023 @default.
• W1564129188 crossrefType "journal-article" @default.
• W1564129188 hasAuthorship W1564129188A5004117880 @default.
• W1564129188 hasAuthorship W1564129188A5012898979 @default.
• W1564129188 hasAuthorship W1564129188A5015552885 @default.
• W1564129188 hasAuthorship W1564129188A5026369750 @default.
• W1564129188 hasAuthorship W1564129188A5036740014 @default.
• W1564129188 hasAuthorship W1564129188A5041764652 @default.
• W1564129188 hasAuthorship W1564129188A5050170161 @default.
• W1564129188 hasAuthorship W1564129188A5062824684 @default.
• W1564129188 hasAuthorship W1564129188A5071319432 @default.
• W1564129188 hasBestOaLocation W15641291882 @default.
• W1564129188 hasConcept C126322002 @default.
• W1564129188 hasConcept C150903083 @default.
• W1564129188 hasConcept C185592680 @default.
• W1564129188 hasConcept C202751555 @default.
• W1564129188 hasConcept C203014093 @default.
• W1564129188 hasConcept C207001950 @default.
• W1564129188 hasConcept C207480886 @default.
• W1564129188 hasConcept C2775933838 @default.
• W1564129188 hasConcept C2776027960 @default.
• W1564129188 hasConcept C2778012357 @default.
• W1564129188 hasConcept C2780035454 @default.
• W1564129188 hasConcept C535046627 @default.
• W1564129188 hasConcept C55493867 @default.
• W1564129188 hasConcept C556039675 @default.
• W1564129188 hasConcept C71924100 @default.
• W1564129188 hasConcept C81603835 @default.
• W1564129188 hasConcept C86803240 @default.
• W1564129188 hasConcept C98274493 @default.
• W1564129188 hasConceptScore W1564129188C126322002 @default.
• W1564129188 hasConceptScore W1564129188C150903083 @default.
• W1564129188 hasConceptScore W1564129188C185592680 @default.
• W1564129188 hasConceptScore W1564129188C202751555 @default.
• W1564129188 hasConceptScore W1564129188C203014093 @default.
• W1564129188 hasConceptScore W1564129188C207001950 @default.
• W1564129188 hasConceptScore W1564129188C207480886 @default.
• W1564129188 hasConceptScore W1564129188C2775933838 @default.
• W1564129188 hasConceptScore W1564129188C2776027960 @default.
• W1564129188 hasConceptScore W1564129188C2778012357 @default.
• W1564129188 hasConceptScore W1564129188C2780035454 @default.
• W1564129188 hasConceptScore W1564129188C535046627 @default.
• W1564129188 hasConceptScore W1564129188C55493867 @default.
• W1564129188 hasConceptScore W1564129188C556039675 @default.
• W1564129188 hasConceptScore W1564129188C71924100 @default.
• W1564129188 hasConceptScore W1564129188C81603835 @default.
• W1564129188 hasConceptScore W1564129188C86803240 @default.
• W1564129188 hasConceptScore W1564129188C98274493 @default.
• W1564129188 hasIssue "4" @default.
• W1564129188 hasLocation W15641291881 @default.
• W1564129188 hasLocation W15641291882 @default.
• W1564129188 hasLocation W15641291883 @default.
• W1564129188 hasLocation W15641291884 @default.
• W1564129188 hasOpenAccess W1564129188 @default.
• W1564129188 hasPrimaryLocation W15641291881 @default.
• W1564129188 hasRelatedWork W1659709475 @default.
• W1564129188 hasRelatedWork W2149693878 @default.

• next