Matches in SemOpenAlex for { <https://semopenalex.org/work/W1564175510> ?p ?o ?g. }
- W1564175510 endingPage "3797" @default.
- W1564175510 startingPage "3790" @default.
- W1564175510 abstract "Abstract Syk protein tyrosine kinase (PTK) is involved in signaling in leukocytes. In macrophages, Fcγ-receptor cross-linking induces Syk PTK phosphorylation and activation, resulting in Syk-dependent events required for phagocytosis and mediator release. We hypothesized that Syk antisense oligodeoxynucleotides (ASO) delivered by aerosol to rat lungs in vivo would depress Syk PTK expression, mediator release from alveolar macrophages, and Syk-dependent pulmonary inflammation. RT-PCR and RT-in situ PCR demonstrated that aerosolized Syk ASO administration reduced Syk mRNA expression from alveolar macrophages compared with cells isolated from sham-treated rats. Western blot analysis confirmed that Syk PTK expression was reduced after Syk ASO treatment. Compared with sham-treated rats (scrambled oligodeoxynucleotide), Syk ASO treatment suppressed Fcγ-receptor-mediated nitric oxide (86.0 ± 8.3%) and TNF (73.1 ± 3.1%) production by alveolar macrophages stimulated with IgG-anti-IgG complexes. In contrast, Fcγ-receptor-induced IL-1β release was unaffected by Syk ASO treatment. Additionally, Syk ASO suppressed Ag-induced pulmonary inflammation, suggesting that Syk ASO may prove useful as an anti-inflammatory therapy in disorders such as asthma." @default.
- W1564175510 created "2016-06-24" @default.
- W1564175510 creator A5002130693 @default.
- W1564175510 creator A5006782649 @default.
- W1564175510 creator A5008503571 @default.
- W1564175510 creator A5009527608 @default.
- W1564175510 creator A5021861175 @default.
- W1564175510 creator A5032289693 @default.
- W1564175510 creator A5033271716 @default.
- W1564175510 creator A5037221383 @default.
- W1564175510 creator A5048203151 @default.
- W1564175510 creator A5059562474 @default.
- W1564175510 creator A5060492898 @default.
- W1564175510 creator A5064630853 @default.
- W1564175510 creator A5079088452 @default.
- W1564175510 date "2000-04-01" @default.
- W1564175510 modified "2023-10-16" @default.
- W1564175510 title "Aerosolized Syk Antisense Suppresses Syk Expression, Mediator Release from Macrophages, and Pulmonary Inflammation" @default.
- W1564175510 cites W1493354087 @default.
- W1564175510 cites W1519260014 @default.
- W1564175510 cites W1545383294 @default.
- W1564175510 cites W1605822460 @default.
- W1564175510 cites W1909573815 @default.
- W1564175510 cites W1924609456 @default.
- W1564175510 cites W1949381048 @default.
- W1564175510 cites W1967234833 @default.
- W1564175510 cites W1969411212 @default.
- W1564175510 cites W1970956917 @default.
- W1564175510 cites W1971290197 @default.
- W1564175510 cites W1982287477 @default.
- W1564175510 cites W1986549185 @default.
- W1564175510 cites W1995484947 @default.
- W1564175510 cites W1995900983 @default.
- W1564175510 cites W2015352271 @default.
- W1564175510 cites W2016738490 @default.
- W1564175510 cites W2051140711 @default.
- W1564175510 cites W2057675739 @default.
- W1564175510 cites W2058093119 @default.
- W1564175510 cites W2063320302 @default.
- W1564175510 cites W2088145469 @default.
- W1564175510 cites W2127618101 @default.
- W1564175510 cites W2131317265 @default.
- W1564175510 cites W2139494439 @default.
- W1564175510 cites W2142393231 @default.
- W1564175510 cites W2144935474 @default.
- W1564175510 cites W2147149491 @default.
- W1564175510 cites W2155341876 @default.
- W1564175510 cites W2158093352 @default.
- W1564175510 cites W2340893422 @default.
- W1564175510 cites W2409470531 @default.
- W1564175510 cites W2413658434 @default.
- W1564175510 doi "https://doi.org/10.4049/jimmunol.164.7.3790" @default.
- W1564175510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10725739" @default.
- W1564175510 hasPublicationYear "2000" @default.
- W1564175510 type Work @default.
- W1564175510 sameAs 1564175510 @default.
- W1564175510 citedByCount "65" @default.
- W1564175510 countsByYear W15641755102012 @default.
- W1564175510 countsByYear W15641755102013 @default.
- W1564175510 countsByYear W15641755102014 @default.
- W1564175510 countsByYear W15641755102015 @default.
- W1564175510 countsByYear W15641755102016 @default.
- W1564175510 countsByYear W15641755102017 @default.
- W1564175510 countsByYear W15641755102018 @default.
- W1564175510 countsByYear W15641755102021 @default.
- W1564175510 countsByYear W15641755102022 @default.
- W1564175510 crossrefType "journal-article" @default.
- W1564175510 hasAuthorship W1564175510A5002130693 @default.
- W1564175510 hasAuthorship W1564175510A5006782649 @default.
- W1564175510 hasAuthorship W1564175510A5008503571 @default.
- W1564175510 hasAuthorship W1564175510A5009527608 @default.
- W1564175510 hasAuthorship W1564175510A5021861175 @default.
- W1564175510 hasAuthorship W1564175510A5032289693 @default.
- W1564175510 hasAuthorship W1564175510A5033271716 @default.
- W1564175510 hasAuthorship W1564175510A5037221383 @default.
- W1564175510 hasAuthorship W1564175510A5048203151 @default.
- W1564175510 hasAuthorship W1564175510A5059562474 @default.
- W1564175510 hasAuthorship W1564175510A5060492898 @default.
- W1564175510 hasAuthorship W1564175510A5064630853 @default.
- W1564175510 hasAuthorship W1564175510A5079088452 @default.
- W1564175510 hasBestOaLocation W15641755101 @default.
- W1564175510 hasConcept C104317684 @default.
- W1564175510 hasConcept C127561419 @default.
- W1564175510 hasConcept C153911025 @default.
- W1564175510 hasConcept C170493617 @default.
- W1564175510 hasConcept C185592680 @default.
- W1564175510 hasConcept C203014093 @default.
- W1564175510 hasConcept C2107291 @default.
- W1564175510 hasConcept C2776914184 @default.
- W1564175510 hasConcept C35174551 @default.
- W1564175510 hasConcept C42362537 @default.
- W1564175510 hasConcept C502942594 @default.
- W1564175510 hasConcept C553184892 @default.
- W1564175510 hasConcept C55493867 @default.
- W1564175510 hasConcept C71924100 @default.
- W1564175510 hasConcept C86803240 @default.
- W1564175510 hasConcept C95444343 @default.
- W1564175510 hasConceptScore W1564175510C104317684 @default.