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• W1564438018 abstract "Lung transplantation is the treatment of choice for patients with end-stage lung disease. However, long-term survival is limited due to the development of chronic rejection in the donor lung of the transplant recipient, called bronchiolitis obliterans syndrome (BOS). BOS is diagnosed after lung transplantation when a decline in lung function occurs, which is not due to rejection, infection or problems of the bronchial anastomosis. The development of BOS is characterized by persistent injury of the airway epithelium that is caused by several factors. This process leads to inflammation and remodeling, which is followed by an aberrant repair response, and finally fibrosis and occlusion of the small airways of the allograft. When BOS is diagnosed, the process is already at an advanced and mostly irreversible stage and treatment options are limited. The current status of diagnosis of BOS clearly indicates the need for biomarkers in serum and DNA that may detect processes leading to BOS before the decline in lung function occurs. These unmet needs are the basis of this thesis. TLRs are critical molecules for activation of the innate immune system by recognition of pathogens, and they can prevent the induction of allograft tolerance. Genetic polymorphisms in Toll-like receptor (TLR)2, TLR4 and TLR9 might contribute to patients’ susceptibility for BOS. These genetic polymorphisms could predispose to increased secretion of pro-inflammatory cytokines, causing injury and inflammation of the airway epithelium. The exact role of different types of cytokines in rejection or tolerance of the allograft is under debate. We showed that the T helper (Th)1 cytokines were similar between patients who developed BOS (BOSpos)and those who did not (BOSneg)patients. However, the Th2 cytokines revealed a different pattern between these two groups. This suggests that Th2 cytokines are involved in the process of chronic rejection, possibly due to the inhibition of transplant tolerance, the absence of inhibition of the Th1 response and the influence on proliferation of regulatory T-cells. In relation to excessive injury and chronic inflammation, the process of fibrogenesis is considered to be of central importance to the development of BOS. Normally, after injury of the airway epithelium an adequate repair mechanism is required to prevent fibrogenesis. BOSpos patients, however, seem to have an impaired repair mechanism and a profibrotic airway milieu. They had a different genotype distribution of matrix metalloproteinase (MMP)7 and lower levels of MMP-7 than BOSneg patients which might contribute to an impaired repair mechanism of the airway epithelium. Besides, there is more degradation and turnover of the extracellular matrix in BOSpos patients than in BOSneg patients as shown by increased levels of MMP-9. Though, the functionality of the genetic polymorphisms in the caveolin-1 (CAV1) gene is not known, it might contribute to fibrogenesis as well through the transforming growth factor beta signaling pathway.In conclusion, genetic polymorphisms in TLRs, MMP7 and CAV1 and biomarkers in serum, such as Th2 cytokines, MMP-7 and MMP-9, are related to the development of BOS after lung transplantation, and may be potential biomarkers for clinical decision making." @default.
• W1564438018 created "2016-06-24" @default.
• W1564438018 creator A5070097804 @default.
• W1564438018 date "2012-01-17" @default.
• W1564438018 modified "2023-09-26" @default.
• W1564438018 title "Bronchiolitis obliterans syndrome after lung transplantation: biomarkers for inflammation and fibrogenesis" @default.
• W1564438018 cites W12802298 @default.
• W1564438018 cites W132663712 @default.
• W1564438018 cites W1480758311 @default.
• W1564438018 cites W1488829562 @default.
• W1564438018 cites W1505978562 @default.
• W1564438018 cites W1508593978 @default.
• W1564438018 cites W1511155802 @default.
• W1564438018 cites W1520365933 @default.
• W1564438018 cites W1527826000 @default.
• W1564438018 cites W1533629006 @default.
• W1564438018 cites W1561573262 @default.
• W1564438018 cites W1562618544 @default.
• W1564438018 cites W1567385135 @default.
• W1564438018 cites W1587682423 @default.
• W1564438018 cites W1589544688 @default.
• W1564438018 cites W1599375505 @default.
• W1564438018 cites W1649157390 @default.
• W1564438018 cites W1676912318 @default.
• W1564438018 cites W1715352648 @default.
• W1564438018 cites W180714979 @default.
• W1564438018 cites W1812585379 @default.
• W1564438018 cites W1839126941 @default.
• W1564438018 cites W1900847658 @default.
• W1564438018 cites W1947733508 @default.
• W1564438018 cites W1956701448 @default.
• W1564438018 cites W1965139309 @default.
• W1564438018 cites W1965538102 @default.
• W1564438018 cites W1966618606 @default.
• W1564438018 cites W1966974215 @default.
• W1564438018 cites W1967224833 @default.
• W1564438018 cites W1967342020 @default.
• W1564438018 cites W1967434961 @default.
• W1564438018 cites W1968110756 @default.
• W1564438018 cites W1968143482 @default.
• W1564438018 cites W1968523247 @default.
• W1564438018 cites W1969459009 @default.
• W1564438018 cites W1971017769 @default.
• W1564438018 cites W1972416920 @default.
• W1564438018 cites W1973312382 @default.
• W1564438018 cites W1974778378 @default.
• W1564438018 cites W1974793843 @default.
• W1564438018 cites W1975168313 @default.
• W1564438018 cites W1975667891 @default.
• W1564438018 cites W1975685884 @default.
• W1564438018 cites W1977027086 @default.
• W1564438018 cites W1977327120 @default.
• W1564438018 cites W1978081401 @default.
• W1564438018 cites W1978359249 @default.
• W1564438018 cites W1978722218 @default.
• W1564438018 cites W1980325398 @default.
• W1564438018 cites W1981123762 @default.
• W1564438018 cites W1982460393 @default.
• W1564438018 cites W1983403805 @default.
• W1564438018 cites W1986834738 @default.
• W1564438018 cites W1986974750 @default.
• W1564438018 cites W1987229311 @default.
• W1564438018 cites W1987445277 @default.
• W1564438018 cites W1987825791 @default.
• W1564438018 cites W1988562670 @default.
• W1564438018 cites W1989006394 @default.
• W1564438018 cites W1989346368 @default.
• W1564438018 cites W1989697230 @default.
• W1564438018 cites W1989880720 @default.
• W1564438018 cites W1989935661 @default.
• W1564438018 cites W1990457145 @default.
• W1564438018 cites W1991398445 @default.
• W1564438018 cites W1993492048 @default.
• W1564438018 cites W1993707861 @default.
• W1564438018 cites W1994786795 @default.
• W1564438018 cites W1997135307 @default.
• W1564438018 cites W1998428164 @default.
• W1564438018 cites W1998772929 @default.
• W1564438018 cites W2001043262 @default.
• W1564438018 cites W2003091636 @default.
• W1564438018 cites W2004780712 @default.
• W1564438018 cites W2004810104 @default.
• W1564438018 cites W2005804757 @default.
• W1564438018 cites W2008556349 @default.
• W1564438018 cites W2008640098 @default.
• W1564438018 cites W2009484147 @default.
• W1564438018 cites W2009724225 @default.
• W1564438018 cites W2010472128 @default.
• W1564438018 cites W2011212093 @default.
• W1564438018 cites W2011223603 @default.
• W1564438018 cites W2011415380 @default.
• W1564438018 cites W2011846108 @default.
• W1564438018 cites W2013199887 @default.
• W1564438018 cites W2013612680 @default.
• W1564438018 cites W2014078838 @default.
• W1564438018 cites W2015113373 @default.
• W1564438018 cites W2015517794 @default.
• W1564438018 cites W2015548356 @default.
• W1564438018 cites W2016090496 @default.
• W1564438018 cites W2016251536 @default.

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