FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1564544043> ?p ?o ?g. }

• W1564544043 endingPage "1161" @default.
• W1564544043 startingPage "1152" @default.
• W1564544043 abstract "Pancreatic enzyme replacement therapy (PERT) is necessary to prevent severe maldigestion and unwanted weight loss associated with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP) or pancreatic surgery (PS).To assess the long-term safety and efficacy of pancrelipase (pancreatin) delayed-release capsules (Creon) in this population.This was a 6-month, open-label extension of a 7-day, double-blind, placebo-controlled study enrolling patients ≥18 years old with confirmed EPI due to CP or PS who were previously receiving PERT. Patients received individualised pancrelipase doses as directed by investigators (administered as Creon 24 000-lipase unit capsules).Overall, 48 of 51 patients completed the open-label phase; one withdrew due to the unrelated treatment-emergent adverse event (TEAE) of cutaneous burns and two were lost to follow-up. The mean age was 50.9 years, 70.6% of patients were male, 76.5% had CP and 23.5% had undergone PS. The mean±s.d. pancrelipase dose was 186960±74640 lipase units/day. TEAEs were reported by 22 patients (43.1%) overall. Only four patients (7.8%) had TEAEs that were considered treatment related. From double-blind phase baseline to end of the open-label period, subjects achieved a mean±s.d. body weight increase of 2.7±3.4 kg (P<0.0001) and change in daily stool frequency of -1.0±1.3 (P<0.001). Improvements in abdominal pain, flatulence and stool consistency were observed.Pancrelipase was well tolerated over 6 months and resulted in statistically significant weight gain and reduced stool frequency in patients with EPI due to CP or PS previously managed with standard PERT." @default.
• W1564544043 created "2016-06-24" @default.
• W1564544043 creator A5007740474 @default.
• W1564544043 creator A5014292317 @default.
• W1564544043 creator A5021037951 @default.
• W1564544043 creator A5021041321 @default.
• W1564544043 creator A5067618943 @default.
• W1564544043 creator A5073913665 @default.
• W1564544043 creator A5076697041 @default.
• W1564544043 creator A5084861756 @default.
• W1564544043 date "2011-03-21" @default.
• W1564544043 modified "2023-10-01" @default.
• W1564544043 title "A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery" @default.
• W1564544043 cites W131964014 @default.
• W1564544043 cites W1588012644 @default.
• W1564544043 cites W1965738864 @default.
• W1564544043 cites W1966530448 @default.
• W1564544043 cites W1967449094 @default.
• W1564544043 cites W1971316765 @default.
• W1564544043 cites W1972703234 @default.
• W1564544043 cites W1985462234 @default.
• W1564544043 cites W1987017400 @default.
• W1564544043 cites W1996270246 @default.
• W1564544043 cites W2009336667 @default.
• W1564544043 cites W2011769683 @default.
• W1564544043 cites W2013838276 @default.
• W1564544043 cites W2022687215 @default.
• W1564544043 cites W2031968580 @default.
• W1564544043 cites W2041508572 @default.
• W1564544043 cites W2051745786 @default.
• W1564544043 cites W2055855735 @default.
• W1564544043 cites W2065734714 @default.
• W1564544043 cites W2066212396 @default.
• W1564544043 cites W2069821416 @default.
• W1564544043 cites W2071201153 @default.
• W1564544043 cites W2077083610 @default.
• W1564544043 cites W2079170831 @default.
• W1564544043 cites W2080291985 @default.
• W1564544043 cites W2086291215 @default.
• W1564544043 cites W2089970850 @default.
• W1564544043 cites W2097642125 @default.
• W1564544043 cites W2144114784 @default.
• W1564544043 cites W2147892054 @default.
• W1564544043 cites W2149787927 @default.
• W1564544043 cites W2241401655 @default.
• W1564544043 cites W4247652048 @default.
• W1564544043 doi "https://doi.org/10.1111/j.1365-2036.2011.04631.x" @default.
• W1564544043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21418260" @default.
• W1564544043 hasPublicationYear "2011" @default.
• W1564544043 type Work @default.
• W1564544043 sameAs 1564544043 @default.
• W1564544043 citedByCount "83" @default.
• W1564544043 countsByYear W15645440432012 @default.
• W1564544043 countsByYear W15645440432013 @default.
• W1564544043 countsByYear W15645440432014 @default.
• W1564544043 countsByYear W15645440432015 @default.
• W1564544043 countsByYear W15645440432016 @default.
• W1564544043 countsByYear W15645440432017 @default.
• W1564544043 countsByYear W15645440432018 @default.
• W1564544043 countsByYear W15645440432019 @default.
• W1564544043 countsByYear W15645440432020 @default.
• W1564544043 countsByYear W15645440432021 @default.
• W1564544043 countsByYear W15645440432022 @default.
• W1564544043 countsByYear W15645440432023 @default.
• W1564544043 crossrefType "journal-article" @default.
• W1564544043 hasAuthorship W1564544043A5007740474 @default.
• W1564544043 hasAuthorship W1564544043A5014292317 @default.
• W1564544043 hasAuthorship W1564544043A5021037951 @default.
• W1564544043 hasAuthorship W1564544043A5021041321 @default.
• W1564544043 hasAuthorship W1564544043A5067618943 @default.
• W1564544043 hasAuthorship W1564544043A5073913665 @default.
• W1564544043 hasAuthorship W1564544043A5076697041 @default.
• W1564544043 hasAuthorship W1564544043A5084861756 @default.
• W1564544043 hasConcept C126322002 @default.
• W1564544043 hasConcept C141071460 @default.
• W1564544043 hasConcept C142724271 @default.
• W1564544043 hasConcept C197934379 @default.
• W1564544043 hasConcept C204787440 @default.
• W1564544043 hasConcept C27081682 @default.
• W1564544043 hasConcept C2775913212 @default.
• W1564544043 hasConcept C2775967933 @default.
• W1564544043 hasConcept C2776670229 @default.
• W1564544043 hasConcept C2777152358 @default.
• W1564544043 hasConcept C2908647359 @default.
• W1564544043 hasConcept C511355011 @default.
• W1564544043 hasConcept C535046627 @default.
• W1564544043 hasConcept C544821477 @default.
• W1564544043 hasConcept C71924100 @default.
• W1564544043 hasConcept C90924648 @default.
• W1564544043 hasConcept C99454951 @default.
• W1564544043 hasConceptScore W1564544043C126322002 @default.
• W1564544043 hasConceptScore W1564544043C141071460 @default.
• W1564544043 hasConceptScore W1564544043C142724271 @default.
• W1564544043 hasConceptScore W1564544043C197934379 @default.
• W1564544043 hasConceptScore W1564544043C204787440 @default.
• W1564544043 hasConceptScore W1564544043C27081682 @default.
• W1564544043 hasConceptScore W1564544043C2775913212 @default.
• W1564544043 hasConceptScore W1564544043C2775967933 @default.

• next