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• W1564749019 endingPage "1570" @default.
• W1564749019 startingPage "1558" @default.
• W1564749019 abstract "Phenotypic expression of human leukocyte antigen (HLA)‐E on the surface of tumor lesions includes intact heterodimer [HLA‐E heavy chain and β2‐microglobulin (β2m)] and β2m‐free monomer. Anti‐HLA‐E monoclonal antibodies (mAbs), MEM‐E/02 or 3D12 bind to the peptide sequences in β2m‐free HLA‐E, which is common and shared with HLA‐Ia monomers. A newly developed monospecific anti‐HLA‐E mAb (TFL‐033) recognizes HLA‐E‐restricted peptide sequences on α1 and α2 helices away from β2‐m‐site. Tumor progression may involve shedding of β2‐m from HLA‐E or overexpression of β2m‐free monomers. There is a need to identify and distinguish the different phenotypic expression of HLA‐E, particularly the intact heterodimer from the β2m‐free monomer on the surface of tumor lesions. Because of the unique peptide‐binding affinities of the mAbs, it is hypothesized that TFL‐033 and MEM‐E/02 may distinguish the phenotypic expressions of cell surface HLA‐E during stages of tumor progression. Only TFL‐033 stained diffusely the cytoplasm of normal mucosa. The incidence and intensity of TFL‐033 staining of the cell surface in early stages, poorly or undifferentiated and non‐nodal lesions and in diffuse carcinoma is greater than that of MEM‐E/02. Whereas MEM‐E/02 stained terminal stages, adenocarcinoma and lymph node metastatic lesions intensely, either owing to increased expression of β2m‐free HLA‐E with tumor progression or owing to expression of HLA‐Ia molecules. Our study evaluates the relative diagnostic potential of HLA‐E‐monospecific TFL‐033 and the HLA‐Ia‐reactive MEM‐E/02 for determining the specific distribution and immunodiagnosis of different phenotypic expression HLA‐E in tumor lesions, and the structural and functional alterations undergone by HLA‐E during tumor progression." @default.
• W1564749019 created "2016-06-24" @default.
• W1564749019 creator A5027509326 @default.
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• W1564749019 date "2013-12-11" @default.
• W1564749019 modified "2023-10-16" @default.
• W1564749019 title "Gastric cancer progression may involve a shift in HLA-E profile from an intact heterodimer to β2-microglobulin-free monomer" @default.
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• W1564749019 doi "https://doi.org/10.1002/ijc.28484" @default.
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• W1564749019 hasPublicationYear "2013" @default.
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