Matches in SemOpenAlex for { <https://semopenalex.org/work/W1564749278> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W1564749278 abstract "Proteins are chains of amino acids whose sequence determines its 3D structure after a folding process. As the 3D structure of a protein exclusively determines its functionality (transport and transduction of biological signals, the possible enzymatic activity of some proteins, etc.), there is a high interest in the determination of the structure of any given proteins. Experimental methods such as X-ray crystallography and nuclear magnetic resonance (NMR) allow the determination of the 3D structure of a protein although they are complex and expensive. Thus, only about the 2% of the known proteins has known structures currently. The so called, protein structure prediction (PSP) problem is the approach to find the 3D structures of proteins by using computers. This work proposes an approach to the protein structure prediction (PSP) problem: PITAGORAS-PSP (Parallel Implemented procedure with Template information, Ab initio Global Optimization, and Rotamer Analysis and Statistics for Protein Structure Prediction). This way, taking into account its name, our procedure represents a hybrid approach that takes advantage of previous knowledge about the known protein structures to improve the effectiveness of an ab initio procedure for the PSP problem. Moreover, the procedure benefits from a parallel and distributed implementation of a multi-objective evolutionary approach that allows faster and wider exploration of the conformation space. The experimental results obtained from the present implementation of our procedure show improvements with respect to previously proposed procedures in the proteins selected as benchmarks from the CASP set (up to 28% of RMSD improvement with respect to one of the best procedures known at this moment in some proteins). We also present a new method to extract better torsion angles from protein structures, it can be used to build an improved data base for torsion angles that aids in the knowledge extraction from the known structures. Our hybrid approach can be used as the main method to predict protein structures, but it can be also used to refine predictions of other methods, due to its capabilities to take advantage of results from other approaches." @default.
- W1564749278 created "2016-06-24" @default.
- W1564749278 creator A5044332891 @default.
- W1564749278 creator A5067662171 @default.
- W1564749278 date "2013-04-12" @default.
- W1564749278 modified "2023-09-23" @default.
- W1564749278 title "A parallel multi-objective optimization procedure for protein structure prediction" @default.
- W1564749278 hasPublicationYear "2013" @default.
- W1564749278 type Work @default.
- W1564749278 sameAs 1564749278 @default.
- W1564749278 citedByCount "0" @default.
- W1564749278 crossrefType "dissertation" @default.
- W1564749278 hasAuthorship W1564749278A5044332891 @default.
- W1564749278 hasAuthorship W1564749278A5067662171 @default.
- W1564749278 hasConcept C104317684 @default.
- W1564749278 hasConcept C11413529 @default.
- W1564749278 hasConcept C136475424 @default.
- W1564749278 hasConcept C152769699 @default.
- W1564749278 hasConcept C167625842 @default.
- W1564749278 hasConcept C177264268 @default.
- W1564749278 hasConcept C178790620 @default.
- W1564749278 hasConcept C18051474 @default.
- W1564749278 hasConcept C185592680 @default.
- W1564749278 hasConcept C199360897 @default.
- W1564749278 hasConcept C204328495 @default.
- W1564749278 hasConcept C2781442258 @default.
- W1564749278 hasConcept C41008148 @default.
- W1564749278 hasConcept C41584329 @default.
- W1564749278 hasConcept C45484198 @default.
- W1564749278 hasConcept C4668613 @default.
- W1564749278 hasConcept C47701112 @default.
- W1564749278 hasConcept C55493867 @default.
- W1564749278 hasConcept C66153294 @default.
- W1564749278 hasConcept C69131567 @default.
- W1564749278 hasConcept C70721500 @default.
- W1564749278 hasConcept C86803240 @default.
- W1564749278 hasConceptScore W1564749278C104317684 @default.
- W1564749278 hasConceptScore W1564749278C11413529 @default.
- W1564749278 hasConceptScore W1564749278C136475424 @default.
- W1564749278 hasConceptScore W1564749278C152769699 @default.
- W1564749278 hasConceptScore W1564749278C167625842 @default.
- W1564749278 hasConceptScore W1564749278C177264268 @default.
- W1564749278 hasConceptScore W1564749278C178790620 @default.
- W1564749278 hasConceptScore W1564749278C18051474 @default.
- W1564749278 hasConceptScore W1564749278C185592680 @default.
- W1564749278 hasConceptScore W1564749278C199360897 @default.
- W1564749278 hasConceptScore W1564749278C204328495 @default.
- W1564749278 hasConceptScore W1564749278C2781442258 @default.
- W1564749278 hasConceptScore W1564749278C41008148 @default.
- W1564749278 hasConceptScore W1564749278C41584329 @default.
- W1564749278 hasConceptScore W1564749278C45484198 @default.
- W1564749278 hasConceptScore W1564749278C4668613 @default.
- W1564749278 hasConceptScore W1564749278C47701112 @default.
- W1564749278 hasConceptScore W1564749278C55493867 @default.
- W1564749278 hasConceptScore W1564749278C66153294 @default.
- W1564749278 hasConceptScore W1564749278C69131567 @default.
- W1564749278 hasConceptScore W1564749278C70721500 @default.
- W1564749278 hasConceptScore W1564749278C86803240 @default.
- W1564749278 hasLocation W15647492781 @default.
- W1564749278 hasOpenAccess W1564749278 @default.
- W1564749278 hasPrimaryLocation W15647492781 @default.
- W1564749278 hasRelatedWork W1589469140 @default.
- W1564749278 hasRelatedWork W1594583051 @default.
- W1564749278 hasRelatedWork W2069209943 @default.
- W1564749278 hasRelatedWork W2185380528 @default.
- W1564749278 hasRelatedWork W2315362862 @default.
- W1564749278 hasRelatedWork W2427345900 @default.
- W1564749278 hasRelatedWork W2477436522 @default.
- W1564749278 hasRelatedWork W2497136351 @default.
- W1564749278 hasRelatedWork W2509597016 @default.
- W1564749278 hasRelatedWork W2898472822 @default.
- W1564749278 hasRelatedWork W2906881745 @default.
- W1564749278 hasRelatedWork W2937569020 @default.
- W1564749278 hasRelatedWork W2948328253 @default.
- W1564749278 hasRelatedWork W2954705142 @default.
- W1564749278 hasRelatedWork W2995531725 @default.
- W1564749278 hasRelatedWork W2998339722 @default.
- W1564749278 hasRelatedWork W3086526877 @default.
- W1564749278 hasRelatedWork W3132887202 @default.
- W1564749278 hasRelatedWork W78476244 @default.
- W1564749278 hasRelatedWork W2188471504 @default.
- W1564749278 isParatext "false" @default.
- W1564749278 isRetracted "false" @default.
- W1564749278 magId "1564749278" @default.
- W1564749278 workType "dissertation" @default.