FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1564844664> ?p ?o ?g. }

• W1564844664 endingPage "3354" @default.
• W1564844664 startingPage "3349" @default.
• W1564844664 abstract "Abstract The plasma protein factor H (FH) inhibits the alternative pathway of complement activation. Previous work has shown that FH binds to group A streptococci and that the interaction does not interfere with the complement-inhibitory capacity of FH. In this work, we report a molecular analysis of this interaction. In absorption experiments with human plasma, M protein-expressing group A streptococci bound both FH and FH-like protein-1 (FHL-1), an active 42-kDa splice product of the FH-gene transcript comprising the first 7 of its 20 short consensus repeat (SCR) domains. rFHL-1 also bound to M protein-expressing streptococci, but rFH fragments containing SCR 1–5 or SCR 1–6 did not. rFHL-1 bound to purified M5 protein with an affinity that was higher than the value calculated for the interaction between FH and M5 protein. The binding of radiolabeled rFHL-1 to immobilized M5 was blocked completely by unlabeled rFHL-1, but was inhibited only partially by SCR 1–6, emphasizing the importance of SCR 7 for the interaction. In experiments with the FH-related proteins FHR-3 and FHR-4, only the former bound to M protein-expressing streptococci, again pointing to an involvement of SCR 7, since FHR-3, but not FHR-4, contains a domain that is similar to SCR 7. Finally, the interaction between rFHL-1 and purified M5 protein was inhibited by heparin, which binds FH via SCR 7. Together, these data indicate that the interaction between streptococcal M proteins and FH or FHL-1 requires SCR 7." @default.
• W1564844664 created "2016-06-24" @default.
• W1564844664 creator A5003597638 @default.
• W1564844664 creator A5044296113 @default.
• W1564844664 creator A5050326345 @default.
• W1564844664 creator A5058725005 @default.
• W1564844664 creator A5061837492 @default.
• W1564844664 creator A5067381987 @default.
• W1564844664 creator A5074615051 @default.
• W1564844664 creator A5083637905 @default.
• W1564844664 date "1998-04-01" @default.
• W1564844664 modified "2023-10-14" @default.
• W1564844664 title "Identification of a Domain in Human Factor H and Factor H-Like Protein-1 Required for the Interaction with Streptococcal M Proteins" @default.
• W1564844664 cites W1010047185 @default.
• W1564844664 cites W1462658072 @default.
• W1564844664 cites W1492385697 @default.
• W1564844664 cites W1534759813 @default.
• W1564844664 cites W1566240917 @default.
• W1564844664 cites W1569686393 @default.
• W1564844664 cites W1589324068 @default.
• W1564844664 cites W1597302506 @default.
• W1564844664 cites W1600561684 @default.
• W1564844664 cites W1607441142 @default.
• W1564844664 cites W1853641470 @default.
• W1564844664 cites W1857401373 @default.
• W1564844664 cites W1881544354 @default.
• W1564844664 cites W1893651774 @default.
• W1564844664 cites W1905886520 @default.
• W1564844664 cites W1918246416 @default.
• W1564844664 cites W1969211427 @default.
• W1564844664 cites W1972861770 @default.
• W1564844664 cites W1985473616 @default.
• W1564844664 cites W2011323677 @default.
• W1564844664 cites W2012760052 @default.
• W1564844664 cites W2015242897 @default.
• W1564844664 cites W2018662284 @default.
• W1564844664 cites W2027903835 @default.
• W1564844664 cites W2028247608 @default.
• W1564844664 cites W2075021230 @default.
• W1564844664 cites W2076935981 @default.
• W1564844664 cites W2086429777 @default.
• W1564844664 cites W2094275695 @default.
• W1564844664 cites W2133885414 @default.
• W1564844664 cites W2139377393 @default.
• W1564844664 cites W2140599660 @default.
• W1564844664 cites W2145506793 @default.
• W1564844664 cites W2147849116 @default.
• W1564844664 cites W2154893314 @default.
• W1564844664 cites W2155580358 @default.
• W1564844664 cites W2158604726 @default.
• W1564844664 cites W2162140882 @default.
• W1564844664 cites W2273511952 @default.
• W1564844664 cites W2346909892 @default.
• W1564844664 doi "https://doi.org/10.4049/jimmunol.160.7.3349" @default.
• W1564844664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9531294" @default.
• W1564844664 hasPublicationYear "1998" @default.
• W1564844664 type Work @default.
• W1564844664 sameAs 1564844664 @default.
• W1564844664 citedByCount "114" @default.
• W1564844664 countsByYear W15648446642012 @default.
• W1564844664 countsByYear W15648446642013 @default.
• W1564844664 countsByYear W15648446642014 @default.
• W1564844664 countsByYear W15648446642015 @default.
• W1564844664 countsByYear W15648446642017 @default.
• W1564844664 countsByYear W15648446642018 @default.
• W1564844664 countsByYear W15648446642019 @default.
• W1564844664 crossrefType "journal-article" @default.
• W1564844664 hasAuthorship W1564844664A5003597638 @default.
• W1564844664 hasAuthorship W1564844664A5044296113 @default.
• W1564844664 hasAuthorship W1564844664A5050326345 @default.
• W1564844664 hasAuthorship W1564844664A5058725005 @default.
• W1564844664 hasAuthorship W1564844664A5061837492 @default.
• W1564844664 hasAuthorship W1564844664A5067381987 @default.
• W1564844664 hasAuthorship W1564844664A5074615051 @default.
• W1564844664 hasAuthorship W1564844664A5083637905 @default.
• W1564844664 hasBestOaLocation W15648446641 @default.
• W1564844664 hasConcept C107824862 @default.
• W1564844664 hasConcept C111684460 @default.
• W1564844664 hasConcept C11804247 @default.
• W1564844664 hasConcept C14356644 @default.
• W1564844664 hasConcept C153911025 @default.
• W1564844664 hasConcept C159654299 @default.
• W1564844664 hasConcept C185592680 @default.
• W1564844664 hasConcept C2778276568 @default.
• W1564844664 hasConcept C51639874 @default.
• W1564844664 hasConcept C523546767 @default.
• W1564844664 hasConcept C54355233 @default.
• W1564844664 hasConcept C55493867 @default.
• W1564844664 hasConcept C86803240 @default.
• W1564844664 hasConceptScore W1564844664C107824862 @default.
• W1564844664 hasConceptScore W1564844664C111684460 @default.
• W1564844664 hasConceptScore W1564844664C11804247 @default.
• W1564844664 hasConceptScore W1564844664C14356644 @default.
• W1564844664 hasConceptScore W1564844664C153911025 @default.
• W1564844664 hasConceptScore W1564844664C159654299 @default.
• W1564844664 hasConceptScore W1564844664C185592680 @default.
• W1564844664 hasConceptScore W1564844664C2778276568 @default.
• W1564844664 hasConceptScore W1564844664C51639874 @default.

• next