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• W1564852918 abstract "Sulfated progesterone metabolites rise 100-fold in the third trimester of human pregnancy and have been shown to be elevated further in the gestational disorder intrahepatic cholestasis of pregnancy (ICP). Typical concentrations of progesterone sulfates range from 1 to 10 µmol/L in an uncomplicated pregnancy and rise to approximately 40 µmol/L in ICP. At this level they can influence bile acid and lipid metabolism. Studies using human and rodent specimens have shown that sulfated metabolites of progesterone competitively inhibit bile acid homeostasis pathways by functioning as partial agonists of farnesoid X receptor (FXR). This explains the loss of induction of FXR target genes in ICP, and may explain susceptibility to hypercholanaemia and dyslipidaemia in the second half of human pregnancy. Furthermore, progesterone sulfates are competitive inhibitors of biliary influx (NTCP) and efflux (BSEP) transport proteins, actions likely to further exacerbate hypercholanaemia and cholestasis." @default.
• W1564852918 created "2016-06-24" @default.
• W1564852918 creator A5021054482 @default.
• W1564852918 creator A5052297121 @default.
• W1564852918 date "2015-01-01" @default.
• W1564852918 modified "2023-10-01" @default.
• W1564852918 title "Progesterone Metabolites as Farnesoid X Receptor Inhibitors" @default.
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• W1564852918 doi "https://doi.org/10.1159/000371565" @default.
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• W1564852918 hasPublicationYear "2015" @default.
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