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- W156511211 abstract "Hepatocellular carcinoma (HCC) is a highly virulent malignancy with diverse etiology. Identification of a common mediator of aggressive progression of HCC would be extremely beneficial not only for diagnostic/prognostic purposes but also for developing targeted therapies. AEG-1/MTDH/LYRIC gene is amplified in human HCC patients, and overexpression of AEG-1/MTDH/LYRIC has been identified in a high percentage of both hepatitis B virus and hepatitis C virus positive HCC cases, suggesting its key role in regulating hepatocarcinogenesis. Important insights into the molecular mechanisms mediating oncogenic properties of AEG-1/MTDH/LYRIC, especially regulating chemoresistance, angiogenesis, and metastasis, have been obtained from studies using HCC model. Additionally, analysis of HCC model has facilitated the identification of AEG-1/MTDH/LYRIC downstream genes and interacting proteins, thereby unraveling novel players regulating HCC development and progression leading to the development of novel interventional strategies. Characterization of a hepatocyte-specific AEG-1/MTDH/LYRIC transgenic mouse (Alb/AEG-1) has revealed novel aspects of AEG-1/MTDH/LYRIC function in in vivo contexts. Combination of AEG-1/MTDH/LYRIC inhibition and chemotherapy has documented significant efficacy in abrogating human HCC xenografts in nude mice indicating the need for developing effective AEG-1/MTDH/LYRIC inhibition strategies to obtain objective response and survival benefits in terminal HCC patients." @default.
- W156511211 created "2016-06-24" @default.
- W156511211 creator A5091194969 @default.
- W156511211 date "2013-01-01" @default.
- W156511211 modified "2023-10-13" @default.
- W156511211 title "AEG-1/MTDH/LYRIC in Liver Cancer" @default.
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- W156511211 doi "https://doi.org/10.1016/b978-0-12-401676-7.00007-3" @default.
- W156511211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3924581" @default.
- W156511211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23889992" @default.
- W156511211 hasPublicationYear "2013" @default.
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