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- W156514273 abstract "The carcinogenic action of ionizing radiation was investigated in 80 2- to 5-month-old hamsters (Mesocricetus auratus), which were submitted to 3 different doses of 200kv x rays. Twenty animals received single whole-body doses of 300 r, 20 were given single doses of 600 r, and 40 received a total of 600 r given in 4 weekly doses of 150 r each. Within 8 to 10 months, 9 of the 80 hamsters developed generalized lymphomatosis. The incidence of the malignancy in the 3 groups was 5, 10, and 15%, respectively. It was not influenced by the sex of the animals since it developed in 5 females and 4 males. Lymphosarcoraas were found throughout the lymph nodes and as metastases in many organs; the histologic appearance of the tumors was the same in all cases. A large proportion of mitotic figures was present and voluminous cells resembling pseudoplasmacytes predominated. It was concluded on the basis of the results that x radiation is capable of inducing the tumor's in the hamster. Several other tumors were noted in the irradiated animals, including 2 uterine epitheliomas, a nevocarcinoma, an ovarian fibroma, a parathyroid adenoma, and several hepatic cholangiomas. (H.H.D.)" @default.
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- W156514273 date "1960-10-01" @default.
- W156514273 modified "2023-09-23" @default.
- W156514273 title "TUMORS OBSERVED IN THE HAMSTER AFTER WHOLE-BODY IRRADIATION BY MEANS OF X RAYS" @default.
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