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- W1565149721 abstract "To determine serum thiol-disulfide homeostasis in hyperemesis gravidarum.Twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method.Serum disulfide levels were 15.68±4.41 μmol l(-1) in the hyperemesis gravidarum group and 13.49±2.81 μmol l(-1) in the healthy group (P=0.031). Native thiol levels were 213.86±26.29 μmol l(-1) in the hyperemesis gravidarum group and 232.18±19.21 μmol l(-1) in healthy group (P=0.004), and total thiol levels were 245.23±28.58 μmol l(-1) in the hyperemesis gravidarum group and 259.17±19.94 μmol l(-1) in the healthy group (P=0.038).Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease. The thiol-disulfide balance has shifted to the oxidative side. This metabolic disturbance may have a role in the pathogenesis of hyperemesis gravidarum." @default.
- W1565149721 created "2016-06-24" @default.
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- W1565149721 date "2015-07-09" @default.
- W1565149721 modified "2023-10-15" @default.
- W1565149721 title "Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum" @default.
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- W1565149721 doi "https://doi.org/10.1038/jp.2015.81" @default.
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