Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565202930> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1565202930 endingPage "21" @default.
- W1565202930 startingPage "21" @default.
- W1565202930 abstract "The Ca2+-binding protein of the EF-hand type, S100B, is abundantly expressed in and released by astrocytes, and leakage of S100B from damaged astrocytes occurs during the course of acute and chronic brain disorders [1]. Thus, the concept has emerged that S100B might act an unconventional cytokine or a damage-associated molecular pattern protein playing a role in the pathophysiology of neurodegenerative disorders and inflammatory brain diseases. S100B’s pro-inflammatory effects require relatively high concentrations of the protein, while at physiological concentrations S100B exerts trophic effects on neurons. Most, if not all of the extracellular (trophic and toxic) effects of S100B in the brain are mediated by the engagement of RAGE (receptor for advanced glycation end products) [1-2]. For example, high S100B activates RAGE-dependently microglia, stimulating the release of IL-1β and TNF-α and upregulating the expression of the proinflammatory enzyme, COX-2 [3-4]. We show here that high S100B chemoattracts murine microglia via RAGE engagement and RAGE-dependent activation of Src kinase, Ras, PI3K, MEK/ERK1/2, RhoA/ROCK, Rac1/JNK/AP-1, Rac1/NF-κB and, to a lesser extent, p38 MAPK. Recruitment of the adaptor protein, diaphanous-1, a member of the formin protein family, is also required for S100B/RAGE-dependent chemoattraction of microglia. The S100B/RAGE-dependent activation of diaphanous-1/Rac1/JNK/AP-1, Ras/Rac1/NF-κB and, likely, Src/Ras/PI3K/RhoA/diaphanous-1 results in the upregulation of expression of the chemokines, CCL3, CCL5 and CCL12, the release and activity of which are required for S100B to chemoattract microglia. Lastly, RAGE engagement by S100B in microglia results in upregulation of the chemokine receptors, CCR1 and CCR5. These results suggests that S100B might participate in the pathophysiology of brain inflammatory disorders via RAGE-dependent regulation of several inflammationrelated events including attraction and activation of microglia." @default.
- W1565202930 created "2016-06-24" @default.
- W1565202930 creator A5004248703 @default.
- W1565202930 creator A5045015927 @default.
- W1565202930 creator A5065739247 @default.
- W1565202930 creator A5076039484 @default.
- W1565202930 date "2010-01-01" @default.
- W1565202930 modified "2023-09-27" @default.
- W1565202930 title "S100b/RAGE-dependent chemoattraction of microglia" @default.
- W1565202930 doi "https://doi.org/10.13128/ijae-8775" @default.
- W1565202930 hasPublicationYear "2010" @default.
- W1565202930 type Work @default.
- W1565202930 sameAs 1565202930 @default.
- W1565202930 citedByCount "0" @default.
- W1565202930 crossrefType "journal-article" @default.
- W1565202930 hasAuthorship W1565202930A5004248703 @default.
- W1565202930 hasAuthorship W1565202930A5045015927 @default.
- W1565202930 hasAuthorship W1565202930A5065739247 @default.
- W1565202930 hasAuthorship W1565202930A5076039484 @default.
- W1565202930 hasConcept C164027704 @default.
- W1565202930 hasConcept C169760540 @default.
- W1565202930 hasConcept C185592680 @default.
- W1565202930 hasConcept C203014093 @default.
- W1565202930 hasConcept C2776914184 @default.
- W1565202930 hasConcept C2777093181 @default.
- W1565202930 hasConcept C2778857457 @default.
- W1565202930 hasConcept C2779717556 @default.
- W1565202930 hasConcept C2779830541 @default.
- W1565202930 hasConcept C51551487 @default.
- W1565202930 hasConcept C57074206 @default.
- W1565202930 hasConcept C62478195 @default.
- W1565202930 hasConcept C86803240 @default.
- W1565202930 hasConcept C95444343 @default.
- W1565202930 hasConceptScore W1565202930C164027704 @default.
- W1565202930 hasConceptScore W1565202930C169760540 @default.
- W1565202930 hasConceptScore W1565202930C185592680 @default.
- W1565202930 hasConceptScore W1565202930C203014093 @default.
- W1565202930 hasConceptScore W1565202930C2776914184 @default.
- W1565202930 hasConceptScore W1565202930C2777093181 @default.
- W1565202930 hasConceptScore W1565202930C2778857457 @default.
- W1565202930 hasConceptScore W1565202930C2779717556 @default.
- W1565202930 hasConceptScore W1565202930C2779830541 @default.
- W1565202930 hasConceptScore W1565202930C51551487 @default.
- W1565202930 hasConceptScore W1565202930C57074206 @default.
- W1565202930 hasConceptScore W1565202930C62478195 @default.
- W1565202930 hasConceptScore W1565202930C86803240 @default.
- W1565202930 hasConceptScore W1565202930C95444343 @default.
- W1565202930 hasLocation W15652029301 @default.
- W1565202930 hasOpenAccess W1565202930 @default.
- W1565202930 hasPrimaryLocation W15652029301 @default.
- W1565202930 hasRelatedWork W1051817145 @default.
- W1565202930 hasRelatedWork W1539604260 @default.
- W1565202930 hasRelatedWork W1978391012 @default.
- W1565202930 hasRelatedWork W2010778539 @default.
- W1565202930 hasRelatedWork W2047073234 @default.
- W1565202930 hasRelatedWork W2090565997 @default.
- W1565202930 hasRelatedWork W2096461459 @default.
- W1565202930 hasRelatedWork W2254272357 @default.
- W1565202930 hasRelatedWork W2583246184 @default.
- W1565202930 hasRelatedWork W2621041607 @default.
- W1565202930 hasRelatedWork W2766423015 @default.
- W1565202930 hasRelatedWork W2794429897 @default.
- W1565202930 hasRelatedWork W2903052278 @default.
- W1565202930 hasRelatedWork W2912520869 @default.
- W1565202930 hasRelatedWork W2920471095 @default.
- W1565202930 hasRelatedWork W2975278853 @default.
- W1565202930 hasRelatedWork W2989389514 @default.
- W1565202930 hasRelatedWork W3029057146 @default.
- W1565202930 hasRelatedWork W3039062201 @default.
- W1565202930 hasRelatedWork W3039163323 @default.
- W1565202930 hasVolume "115" @default.
- W1565202930 isParatext "false" @default.
- W1565202930 isRetracted "false" @default.
- W1565202930 magId "1565202930" @default.
- W1565202930 workType "article" @default.