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• W1565226989 abstract "A debilitating consequence of diabetes mellitus (DM) is neuropathy which globally affects between 20 -30% of diabetic patients and up to 50% [1, 2]. The lifetime incidence of diabetic neuropathy (DN) is estimated to be up to 45% for type 2 diabetic patients and 59% for type 1 diabetic patients in USA. The risk of DN rises with age, duration of DM, and vascular disease. Characterized by damages in the arms and legs, peripheral neuropathy is the most common complication of DM. The pathophysiology of DN is promoted by several risk factors: microvascular disease, neural hypoxia, and hyperglycemia-induced effects. At the molecular level, the primary cause of diabetic complications is known to be hyperglycemia, which disrupts cellular metabolism by the formation of reactive oxygen species (ROS). In the aspect of nerve functions, ROS formation increases neuron’s susceptibility to damage. In addition, hyperglycemia impedes production of angiogenic and neurotrophic growth factors, which are necessary for normal function of neurons and glial cells and maintenance of vascular structure. The most common presentation of nerve damage due to the effects of hyperglycemia is neuropathic pain. Peripheral neuropathy may cause foot deformities such as hammertoes and unnoticed sores and infections in the numb areas of the foot. Improperly treated infection frequently extends to the bone and requires an amputation of the foot. There have not been any definitive disease-modifying treatments to reverse DN. The current treatment focuses on tight glycemic control which can reduce potential risk factors for further nerve damage and DN-associated pain management. In many studies, deficiency of neurotrophic factors and lack of vascular support have been regarded as key factors in the development DN. Therefore, cell therapy has recently emerged as an attractive therapeutic strategy to meet the needs of both neurotrophic and vascular deficiencies of DN." @default.
• W1565226989 created "2016-06-24" @default.
• W1565226989 creator A5032026790 @default.
• W1565226989 creator A5046688742 @default.
• W1565226989 date "2012-02-29" @default.
• W1565226989 modified "2023-10-18" @default.
• W1565226989 title "Cell Therapy for Diabetic Neuropathy" @default.
• W1565226989 cites W1499075785 @default.
• W1565226989 cites W1499143025 @default.
• W1565226989 cites W1500332700 @default.
• W1565226989 cites W1502896205 @default.
• W1565226989 cites W1513780852 @default.
• W1565226989 cites W1521343817 @default.
• W1565226989 cites W1572399086 @default.
• W1565226989 cites W1573363574 @default.
• W1565226989 cites W1679229092 @default.
• W1565226989 cites W1892764734 @default.
• W1565226989 cites W1964991169 @default.
• W1565226989 cites W1967172766 @default.
• W1565226989 cites W1968034482 @default.
• W1565226989 cites W1970007383 @default.
• W1565226989 cites W1972940420 @default.
• W1565226989 cites W1976624762 @default.
• W1565226989 cites W1976961846 @default.
• W1565226989 cites W1978859651 @default.
• W1565226989 cites W1988144115 @default.
• W1565226989 cites W1989224597 @default.
• W1565226989 cites W1990136121 @default.
• W1565226989 cites W1995797290 @default.
• W1565226989 cites W1998359715 @default.
• W1565226989 cites W1999322200 @default.
• W1565226989 cites W1999579644 @default.
• W1565226989 cites W2008018400 @default.
• W1565226989 cites W2008759079 @default.
• W1565226989 cites W2009485059 @default.
• W1565226989 cites W2012018288 @default.
• W1565226989 cites W2013730613 @default.
• W1565226989 cites W2019542630 @default.
• W1565226989 cites W2019600891 @default.
• W1565226989 cites W2020267609 @default.
• W1565226989 cites W2022551518 @default.
• W1565226989 cites W2023439634 @default.
• W1565226989 cites W2024950877 @default.
• W1565226989 cites W2025139027 @default.
• W1565226989 cites W2025958954 @default.
• W1565226989 cites W2026983868 @default.
• W1565226989 cites W2032281007 @default.
• W1565226989 cites W2032975009 @default.
• W1565226989 cites W2033814735 @default.
• W1565226989 cites W2039041215 @default.
• W1565226989 cites W2043490453 @default.
• W1565226989 cites W2047202595 @default.
• W1565226989 cites W2047702268 @default.
• W1565226989 cites W2049332097 @default.
• W1565226989 cites W2049466721 @default.
• W1565226989 cites W2052649805 @default.
• W1565226989 cites W2053261802 @default.
• W1565226989 cites W2054095354 @default.
• W1565226989 cites W2054947222 @default.
• W1565226989 cites W2056831255 @default.
• W1565226989 cites W2057843591 @default.
• W1565226989 cites W2061010923 @default.
• W1565226989 cites W2064464513 @default.
• W1565226989 cites W2065088165 @default.
• W1565226989 cites W2067294724 @default.
• W1565226989 cites W2067845216 @default.
• W1565226989 cites W2068013747 @default.
• W1565226989 cites W2073715063 @default.
• W1565226989 cites W2074328785 @default.
• W1565226989 cites W2079761925 @default.
• W1565226989 cites W2080577282 @default.
• W1565226989 cites W2080640408 @default.
• W1565226989 cites W2081321708 @default.
• W1565226989 cites W2084258035 @default.
• W1565226989 cites W2098501601 @default.
• W1565226989 cites W2098743872 @default.
• W1565226989 cites W2099548046 @default.
• W1565226989 cites W2103812368 @default.
• W1565226989 cites W2104092076 @default.
• W1565226989 cites W2104918241 @default.
• W1565226989 cites W2105731956 @default.
• W1565226989 cites W2107922629 @default.
• W1565226989 cites W2112180189 @default.
• W1565226989 cites W2112454216 @default.
• W1565226989 cites W2119878763 @default.
• W1565226989 cites W2120533615 @default.
• W1565226989 cites W2122104062 @default.
• W1565226989 cites W2122138696 @default.
• W1565226989 cites W2127209890 @default.
• W1565226989 cites W2128553876 @default.
• W1565226989 cites W2131392472 @default.
• W1565226989 cites W2131840341 @default.
• W1565226989 cites W2133346775 @default.
• W1565226989 cites W2135378032 @default.
• W1565226989 cites W2135463801 @default.
• W1565226989 cites W2139971123 @default.
• W1565226989 cites W2140562414 @default.
• W1565226989 cites W2141049046 @default.
• W1565226989 cites W2141933834 @default.
• W1565226989 cites W2142057145 @default.

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