Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565230971> ?p ?o ?g. }
- W1565230971 endingPage "3724" @default.
- W1565230971 startingPage "3718" @default.
- W1565230971 abstract "Although CD8(+) CTLs are presumed to be an important mediator of protective immunity in HIV-1 infection, the factors that determine CTL antiviral efficiency are poorly understood. Two factors that have been proposed to influence CTL antiviral function are antigenic avidity and epitope specificity. In this study we evaluate these by examining the activity of HIV-1-specific CTL against acutely infected cells. The ability of CTL to kill infected cells is variable and depends more on epitope specificity than functional avidity within the range for the tested clones (50% of maximal killing, 50 pg/ml to 100 ng/ml); killing efficiency is similar for different clones recognizing the same epitope, despite their variation in avidity. When CTL clones are tested for their ability to suppress viral replication, similar results are observed. Inhibition is more dependent on epitope specificity than functional avidity among the tested clones (50% of maximal killing, 20 pg/ml to 20 ng/ml). Thus, CTL specificity can be an overriding factor in the ability of CTL to interact with HIV-1-infected cells, indicating that factors determining the process of epitope presentation on infected cells have a key influence on CTL efficiency. These results suggest that CTL specificity may have a pivotal role in the immunopathogenesis of infection, and that simple quantitative measures of CTL may be insufficient indicators of the CTL response to HIV-1." @default.
- W1565230971 created "2016-06-24" @default.
- W1565230971 creator A5016518899 @default.
- W1565230971 creator A5018205846 @default.
- W1565230971 creator A5054165794 @default.
- W1565230971 creator A5062526829 @default.
- W1565230971 creator A5067647063 @default.
- W1565230971 creator A5091661998 @default.
- W1565230971 date "2003-10-01" @default.
- W1565230971 modified "2023-10-12" @default.
- W1565230971 title "Impacts of Avidity and Specificity on the Antiviral Efficiency of HIV-1-Specific CTL" @default.
- W1565230971 cites W1481708591 @default.
- W1565230971 cites W1523147669 @default.
- W1565230971 cites W1601810440 @default.
- W1565230971 cites W1633472206 @default.
- W1565230971 cites W1655510925 @default.
- W1565230971 cites W1659719610 @default.
- W1565230971 cites W1973398091 @default.
- W1565230971 cites W1978094859 @default.
- W1565230971 cites W1980169905 @default.
- W1565230971 cites W1991670386 @default.
- W1565230971 cites W1993529526 @default.
- W1565230971 cites W2000734326 @default.
- W1565230971 cites W2000776156 @default.
- W1565230971 cites W2011630381 @default.
- W1565230971 cites W2030741604 @default.
- W1565230971 cites W2039751597 @default.
- W1565230971 cites W2048999843 @default.
- W1565230971 cites W2049932413 @default.
- W1565230971 cites W2079504777 @default.
- W1565230971 cites W2081920514 @default.
- W1565230971 cites W2082374693 @default.
- W1565230971 cites W2083255836 @default.
- W1565230971 cites W2084811610 @default.
- W1565230971 cites W2089471930 @default.
- W1565230971 cites W2098822919 @default.
- W1565230971 cites W2103182811 @default.
- W1565230971 cites W2106628454 @default.
- W1565230971 cites W2112601022 @default.
- W1565230971 cites W2124051961 @default.
- W1565230971 cites W2124969212 @default.
- W1565230971 cites W2129114331 @default.
- W1565230971 cites W2130530797 @default.
- W1565230971 cites W2139257243 @default.
- W1565230971 cites W2142316620 @default.
- W1565230971 cites W2144882745 @default.
- W1565230971 cites W2151651155 @default.
- W1565230971 cites W2170128399 @default.
- W1565230971 cites W2330885519 @default.
- W1565230971 cites W4321428183 @default.
- W1565230971 doi "https://doi.org/10.4049/jimmunol.171.7.3718" @default.
- W1565230971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14500671" @default.
- W1565230971 hasPublicationYear "2003" @default.
- W1565230971 type Work @default.
- W1565230971 sameAs 1565230971 @default.
- W1565230971 citedByCount "94" @default.
- W1565230971 countsByYear W15652309712012 @default.
- W1565230971 countsByYear W15652309712013 @default.
- W1565230971 countsByYear W15652309712014 @default.
- W1565230971 countsByYear W15652309712015 @default.
- W1565230971 countsByYear W15652309712016 @default.
- W1565230971 countsByYear W15652309712017 @default.
- W1565230971 countsByYear W15652309712018 @default.
- W1565230971 countsByYear W15652309712019 @default.
- W1565230971 crossrefType "journal-article" @default.
- W1565230971 hasAuthorship W1565230971A5016518899 @default.
- W1565230971 hasAuthorship W1565230971A5018205846 @default.
- W1565230971 hasAuthorship W1565230971A5054165794 @default.
- W1565230971 hasAuthorship W1565230971A5062526829 @default.
- W1565230971 hasAuthorship W1565230971A5067647063 @default.
- W1565230971 hasAuthorship W1565230971A5091661998 @default.
- W1565230971 hasBestOaLocation W15652309711 @default.
- W1565230971 hasConcept C147483822 @default.
- W1565230971 hasConcept C147969180 @default.
- W1565230971 hasConcept C154317977 @default.
- W1565230971 hasConcept C159047783 @default.
- W1565230971 hasConcept C167672396 @default.
- W1565230971 hasConcept C179223381 @default.
- W1565230971 hasConcept C195616568 @default.
- W1565230971 hasConcept C202751555 @default.
- W1565230971 hasConcept C203014093 @default.
- W1565230971 hasConcept C54355233 @default.
- W1565230971 hasConcept C86803240 @default.
- W1565230971 hasConceptScore W1565230971C147483822 @default.
- W1565230971 hasConceptScore W1565230971C147969180 @default.
- W1565230971 hasConceptScore W1565230971C154317977 @default.
- W1565230971 hasConceptScore W1565230971C159047783 @default.
- W1565230971 hasConceptScore W1565230971C167672396 @default.
- W1565230971 hasConceptScore W1565230971C179223381 @default.
- W1565230971 hasConceptScore W1565230971C195616568 @default.
- W1565230971 hasConceptScore W1565230971C202751555 @default.
- W1565230971 hasConceptScore W1565230971C203014093 @default.
- W1565230971 hasConceptScore W1565230971C54355233 @default.
- W1565230971 hasConceptScore W1565230971C86803240 @default.
- W1565230971 hasIssue "7" @default.
- W1565230971 hasLocation W15652309711 @default.
- W1565230971 hasLocation W15652309712 @default.
- W1565230971 hasOpenAccess W1565230971 @default.