FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1565301559> ?p ?o ?g. }

• W1565301559 endingPage "4347" @default.
• W1565301559 startingPage "4336" @default.
• W1565301559 abstract "Peripheral nerve regeneration is dependent on the ability of regenerating neurites to migrate through cellular debris and altered extracellular matrix at the injury site, grow along the residual distal nerve sheath conduit, and reinnervate synaptic targets. In cell culture, growth cones of regenerating axons secrete proteases, specifically plasminogen activators (PAs), which are believed to facilitate growth cone movement by digesting extracellular matrices and cell adhesions. In this study, the PA system was shown to be specifically activated in sensory neurons after sciatic nerve crush in adult mice. The number of sensory neurons expressing urokinase PA receptor (uPAR) mRNA levels increased above sham levels by 8 hr after crush, whereas the number of sensory neurons expressing uPA and tissue PA (tPA) mRNAs was significantly increased by 3 d after crush. PA mRNA levels were also increased at the crush site, with uPA mRNA elevated by 8 hr after crush and tPA and uPAR mRNA levels markedly increased by 7 d. PA-dependent enzymatic activity was significantly increased from 1 to 7 d after crush in nerves that had been crushed compared with uncrushed nerves. Immunohistochemistry showed that tPA was localized within regenerating axons of the sciatic nerve. There were no significant changes in plasminogen activator inhibitor 1 activity between crush and sham after the injury. These results clearly demonstrated that after injury the PA system was rapidly induced in sensory neurons, where it may play an important role in nerve regeneration in vivo ." @default.
• W1565301559 created "2016-06-24" @default.
• W1565301559 creator A5046683620 @default.
• W1565301559 creator A5063058067 @default.
• W1565301559 date "2001-06-15" @default.
• W1565301559 modified "2023-10-15" @default.
• W1565301559 title "Induction of the Plasminogen Activator System Accompanies Peripheral Nerve Regeneration after Sciatic Nerve Crush" @default.
• W1565301559 cites W1489267547 @default.
• W1565301559 cites W1513643699 @default.
• W1565301559 cites W1516264649 @default.
• W1565301559 cites W1532262523 @default.
• W1565301559 cites W1548496378 @default.
• W1565301559 cites W1559486481 @default.
• W1565301559 cites W1565301559 @default.
• W1565301559 cites W1589158534 @default.
• W1565301559 cites W1619042305 @default.
• W1565301559 cites W1652667259 @default.
• W1565301559 cites W1680438956 @default.
• W1565301559 cites W1775749144 @default.
• W1565301559 cites W1824808675 @default.
• W1565301559 cites W1866676984 @default.
• W1565301559 cites W1928513416 @default.
• W1565301559 cites W1950899894 @default.
• W1565301559 cites W1964837678 @default.
• W1565301559 cites W1974801534 @default.
• W1565301559 cites W1983503063 @default.
• W1565301559 cites W1983776987 @default.
• W1565301559 cites W1985328527 @default.
• W1565301559 cites W1986551332 @default.
• W1565301559 cites W1986612369 @default.
• W1565301559 cites W1996722746 @default.
• W1565301559 cites W1997526503 @default.
• W1565301559 cites W2000723452 @default.
• W1565301559 cites W2003593894 @default.
• W1565301559 cites W2007409236 @default.
• W1565301559 cites W2007896060 @default.
• W1565301559 cites W2008094802 @default.
• W1565301559 cites W2008575078 @default.
• W1565301559 cites W2011936885 @default.
• W1565301559 cites W2012132413 @default.
• W1565301559 cites W2013435416 @default.
• W1565301559 cites W2014086967 @default.
• W1565301559 cites W2014435216 @default.
• W1565301559 cites W2015261567 @default.
• W1565301559 cites W2016179551 @default.
• W1565301559 cites W2021613210 @default.
• W1565301559 cites W2023131407 @default.
• W1565301559 cites W2023825486 @default.
• W1565301559 cites W2028199718 @default.
• W1565301559 cites W2030291352 @default.
• W1565301559 cites W2033197469 @default.
• W1565301559 cites W2034903627 @default.
• W1565301559 cites W2040997641 @default.
• W1565301559 cites W2047722898 @default.
• W1565301559 cites W2049631846 @default.
• W1565301559 cites W2050556701 @default.
• W1565301559 cites W2053359070 @default.
• W1565301559 cites W205532431 @default.
• W1565301559 cites W2056474958 @default.
• W1565301559 cites W2058987172 @default.
• W1565301559 cites W2059624922 @default.
• W1565301559 cites W2066135701 @default.
• W1565301559 cites W2070125199 @default.
• W1565301559 cites W2071508374 @default.
• W1565301559 cites W2077019931 @default.
• W1565301559 cites W2078249545 @default.
• W1565301559 cites W2079831464 @default.
• W1565301559 cites W2082077377 @default.
• W1565301559 cites W2093304185 @default.
• W1565301559 cites W2102219674 @default.
• W1565301559 cites W2116382020 @default.
• W1565301559 cites W2120177642 @default.
• W1565301559 cites W2121141343 @default.
• W1565301559 cites W2136872372 @default.
• W1565301559 cites W2137900251 @default.
• W1565301559 cites W2142492617 @default.
• W1565301559 cites W2148624978 @default.
• W1565301559 cites W2162567095 @default.
• W1565301559 cites W2170832108 @default.
• W1565301559 cites W2188291711 @default.
• W1565301559 cites W2299155172 @default.
• W1565301559 cites W2398779045 @default.
• W1565301559 cites W4247615759 @default.
• W1565301559 cites W68079187 @default.
• W1565301559 doi "https://doi.org/10.1523/jneurosci.21-12-04336.2001" @default.
• W1565301559 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762730" @default.
• W1565301559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11404419" @default.
• W1565301559 hasPublicationYear "2001" @default.
• W1565301559 type Work @default.
• W1565301559 sameAs 1565301559 @default.
• W1565301559 citedByCount "92" @default.
• W1565301559 countsByYear W15653015592012 @default.
• W1565301559 countsByYear W15653015592013 @default.
• W1565301559 countsByYear W15653015592014 @default.
• W1565301559 countsByYear W15653015592015 @default.
• W1565301559 countsByYear W15653015592016 @default.
• W1565301559 countsByYear W15653015592017 @default.
• W1565301559 countsByYear W15653015592018 @default.

• next