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- W1565304611 endingPage "e29866" @default.
- W1565304611 startingPage "e29866" @default.
- W1565304611 abstract "Bacteriophages have an essential gene kit that enables their invasion, replication, and production. In addition to this core genome, they can carry accessory genes that dramatically impact bacterial biology, and presumably boost their own success. The content of phage genomes continue to surprise us by revealing new ways that viruses impact bacterial biology. The genome of a Clostridium difficile myovirus, phiCDHM1, contains homologs of three bacterial accessory gene regulator (agr) genes. The agr system is a type of quorum sensing (QS), via which the phage may modify C. difficile interactions with its environment. Although their mechanism of action is unknown, mutants in bacterial versions of these genes impact sporulation and virulence. To explore how phage QS genes may influence C. difficile biology, we examine the main categories of bacterial behavior that phages have been shown to influence and discuss how interactions via QS could influence behavior at a wider level." @default.
- W1565304611 created "2016-06-24" @default.
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- W1565304611 date "2014-07-01" @default.
- W1565304611 modified "2023-10-02" @default.
- W1565304611 title "Bacteriophage behavioral ecology" @default.
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- W1565304611 doi "https://doi.org/10.4161/bact.29866" @default.
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